Development of a high-performance liquid chromatographic-mass spectrometric assay for the specific and sensitive quantification of Ro 64- 0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 745, Issue 2, 2000, Pages 373-388

  Wiltshire, Hugh ^a   Wiltshire, Barbara ^a   Citron, Andrea ^a   Clarke, Tony ^a   Serpe, Carolyn ^b   Gray, Donald ^b   Herron, William ^c  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b BAS Analytics   (United States)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Oseltamivir; Ro 64 0802

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; DICHLORVOS; OSELTAMIVIR; PRODRUG; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DECOMPOSITION; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG STABILITY; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFLUENZA; INFLUENZA VIRUS A; INFLUENZA VIRUS B; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ACETAMIDES; ANIMALS; ANTIVIRAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INFLUENZA, HUMAN; MASS SPECTROMETRY; OSELTAMIVIR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0034682944     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(00)00300-5     Document Type: Article

References (8)

1. Kim C.U., Lew W., Williams M.A., Liu H., Zhang L., Swaminathan S., Bischofberger N., Chen M.S., Mendel D.B., Tai C.Y., Laver W.G., Stevens R.C. J. Am. Chem. Soc. 119:1997;681.
2. Mendel D.B., Tai C.Y., Escarpe P.A., Li W., Sidwell R.W., Huffman J.H., Sweet C., Jakeman K.J., Merson J., Lacy S.A., Lew W., Williams M.A., Zhang L., Chen M.S., Bischofberger N., Kim C.U. Antimicrob. Agents Chemother. 42:1998;640.
3. Treanor J.J., Hayden F.G., Vrooman P.S., Barbarash R., Bettis R., Riff D., Singh S., Kinnersley N., Ward P., Mills R.G. J. Am. Med. Assoc. 283/8:2000;1016.
4. Li W., Escarpe P.A., Eisenberg G., Cundy K., Sweet C., Jakeman K.J., Merson J., Lew W., Williams M.A., Zhang L., Kim C.U., Bischofberger N., Chen M.S., Mendel D.B. Antimicrob. Agents Chemother. 42:1998;647.
5. G. He, J. Massarella, R. Schulz et al., American Association of Pharmaceutical Scientists, Southeast Regional Meeting, 21 June 1999.
6. H.R. Wiltshire, J. Muir, R. Lambkin, S. Davies, Eur. Soc. Clin. Virol. (ESCV), Hamburg, September, 1999.
7. Eisenberg E.J., Cundy K.C. J. Chromatogr. B. 716:1998;267.
8. Oliyai R., Yuan L.-C., Dahl T.C., Swaminathan S., Wang K.-Y., Lee W.A. Pharmaceutical Res. 15:(8):1998;1300.