In vitro stability of cocaine in whole blood and plasma including ecgonine as a target analyte

Therapeutic Drug Monitoring

Volumn 23, Issue 2, 2001, Pages 174-181

  Skopp, Gisela ^a,b,c   Klingmann, Andrea ^a,b   Pötsch, Lucia ^a,b   Mattern, Rainer ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c Institute of Legal Medicine   (Germany)

Author keywords

Benzoylecgonine; Cocaine; Ecgonine methyl ester; Ecgonine stability in blood versus plasma

Indexed keywords

BENZOYLECGONINE; COCAINE; ECGONINE; ECGONINE METHYL ESTER; POTASSIUM FLUORIDE;

ARTICLE; BLOOD; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG MONITORING; DRUG STABILITY; DRUG STORAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; STOICHIOMETRY; TEMPERATURE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; HUMANS; HYDROLYSIS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; PLASMA; SPECIMEN HANDLING; TEMPERATURE;

EID: 0035086676     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200104000-00014     Document Type: Article

References (38)

1. Stability of cocaine in biologic fluids
2. Collection and handling of clinical blood samples to assure the accurate measurement of cocaine concentration
3. The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma
4. Prediction of stability in pharmaceutical preparations XX: Stability evaluation and bioanalysis of cocaine and benzoylecgonine by high-performance liquid chromatography
5. Determination of esterase-catalyzed cocaine metabolite formation by high-performance liquid chromatography with ultraviolet detection
6. Analysis of cocaine, benzoyl-ecgonine, ecgonine methylester and ecgonine by high pressure liquid chromatography/API mass spectrometry and application to a short-term degradation study of cocaine in plasma
7. Study of the stability of cocaine and benzoylecgonine, its major metabolite, in blood samples
8. In vivo and in vitro studies on cocaine metabolism: Ecgonine methyl ester as a major metabolite of cocaine
9. Hydrolysis of cocaine in human plasma by cholinesterase
10. Cocaine metabolism: Cocaine and norcocaine hydrolysis by liver and serum esterases
11. Cocaine: Pharmacokinetics and biotransformation in man
12. Hydrolysis of carbon-labeled cocaine in human serum
13. Improved long-term stability of blood cocaine in evacuated collection tubes
14. A comprehensive study of the stability of cocaine and its metabolites
15. Cocaine: Analysis, pharmacokinetics and metabolic disposition
16. Extraction, quantitative gas chromatographic determination and gas chromatographic/mass spectrometric detection of ecgonine for identification of cocaine and its metabolites in urine
17. Urine concentrations of ecgonine from specimens with low benzoylecgonine levels using a new ecgonine assay
18. Quantitative determination of cocaine and its metabolites benzoylecgonine and ecgonine by gas-liquid chromatography
19. Separation of cocaine, benzoylecgonine, and ecgonine by paper chromatography
20. Detection of ecgonine in urine
21. The analysis of cocaine and its metabolites by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APC1-MS)
22. Simultaneous analysis of cocaine, benzoylecgonine, methylecgonine, and ecgonine in plasma using an exchange resin and gas chromatography - Mass spectrometry
23. Detection of cocaine and its polar transformation products and metabolites in human urine
24. Analysis of cocaine, ecgonine, ecgonine methyl ester, ethylcocaine and norcocaine in human urine using HPLC with post column ion-pair extraction and fluorescence detection
25. Analysis of ecgonine and other cocaine biotransformation products in postmortem whole blood by protein precipitation-extractive alkylation and GC-MS
26. An LC-MS-MS method for the comprehensive analysis of cocaine and cocaine metabolites in meconium
27. Colorimetric determination of serum cholinesterase and its genetic variants by the propionyl-thiocholine-dithiobis(nitrobenzoic acid) procedure
28. Prediction of stability in pharmaceutical preparations XXI: The analysis and kinetics of hydrolysis of a cocaine degradation product, ecgonine methyl ester, plus the pharmacokinetics of cocaine in the dog
29. Cocaine and butyrylcho-linesterase (BChE): Determination of enzymatic parameters
30. Long-term stability of ecgonine methyl ester in urine
31. Mechanisms of cocaine hydrolysis and metabolism in vitro and in vivo: A clarification
32. A preliminary study on the stability of benzodiazepines in blood and plasma stored at 4°C
33. Stability of morphine, morphine-3- and morphine-6-glucuronide in fresh blood, plasma and postmortem blood samples
34. Effect of long-term storage on human plasma cholinesterase activity
35. Stability of pseudocholinesterase in stored blood
36. Stability of butyrylcholinesterase: Thermal inactivation in water and deuterium oxide
37. Ecgonine methyl ester/benzoylecgonine metabolite ratio in serum samples of cocaine consumers taken in police custody in the view of § 24a II of the German traffic act