Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 30, 2011, Pages 3415-3422

  Kamei, Tomonori ^a   Uchimura, Takahide ^a   Nishimiya, Kazuhiro ^a   Kawanishi, Takehiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Column switching; Human plasma; LC MS MS; Pharmacokinetics; Topoisomerase 1 inhibitor

Indexed keywords

ACTIVE METABOLITES; ANALYTES; CITRIC ACID SOLUTION; CLINICAL SAMPLES; CLINICAL TRIAL; COLUMN SWITCHING; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTITATIONS; METHOD DEVELOPMENT; MULTIPLE REACTION MONITORING; PLASMA PROTEIN; PRODRUGS; REANALYSIS; SENSITIVE METHOD; SIMULTANEOUS DETERMINATIONS; TOPOISOMERASES; VALIDATED METHODS;

ACETONITRILE; CARBOXYLATION; CITRIC ACID; ELECTROSPRAY IONIZATION; HYDROCHLORIC ACID; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; PLASMA (HUMAN); PLASMAS; QUALITY CONTROL;

COLUMN CHROMATOGRAPHY;

ACETONITRILE; CARBOXYLIC ACID; CH 0793011; CH 0793076; CH 4556300; CITRIC ACID; DNA TOPOISOMERASE INHIBITOR; DRUG METABOLITE; HYDROCHLORIC ACID; LACTONE; METHANOL; UNCLASSIFIED DRUG;

ARTICLE; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG STRUCTURE; ELECTROSPRAY; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LOWER LIMIT OF QUANTITATION; NORMAL HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

CAMPTOTHECIN; CHROMATOGRAPHY, LIQUID; DIPEPTIDES; DRUG STABILITY; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TOPOISOMERASE I INHIBITORS;

EID: 80555131102     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.09.015     Document Type: Article

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