A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: More accurate evaluation for pharmacokinetic study

Analytical and Bioanalytical Chemistry

Volumn 391, Issue 3, 2008, Pages 1063-1071

  Cao, Yan Guang ^a   Zhang, Ming ^a   Yu, Dan ^a   Shao, Jing Ping ^a   Chen, Yuan Cheng ^a   Liu, Xiao Quan ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Clinical pharmacokinetics; Highly polar drug; Nafamostat mesilate; Solid phase extraction; Unstable drug

Indexed keywords

CONCENTRATION (PROCESS); ELECTROSPRAY IONIZATION; ESTERS; HYDROLYSIS; MASS SPECTROMETRY; PLASMA (HUMAN);

CLINICAL PHARMACOKINETICS; HIGHLY POLAR DRUG; NAFAMOSTAT MESILATE; SOLID-PHASE EXTRACTION; UNSTABLE DRUG;

DRUG PRODUCTS;

GUANIDINE DERIVATIVE; NAFAMSTAT;

ADULT; ARTICLE; BLOOD; CALIBRATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; INSTRUMENTATION; MALE; METHODOLOGY; PH; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TIME; VALIDATION STUDY;

ADULT; CALIBRATION; DRUG STABILITY; FEMALE; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

EID: 43949089130     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-008-2054-4     Document Type: Article

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