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Volumn 852, Issue 1-2, 2007, Pages 77-84
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Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry-Evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabilization of a labile ester-containing drug
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Author keywords
Adenosine 2A agonist; BMS 068645; BMS 068645 acid; DFP; Diisopropyl fluorophosphate; Esterase inhibitor; Liquid chromatography tandem mass spectrometry
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Indexed keywords
ADENOSINETRIPHOSPHATE;
HYDROLYSIS;
MASS SPECTROMETRY;
METABOLITES;
PLASMA (HUMAN);
DIISOPROPYL FLUOROPHOSPHATE;
LIQUID-LIQUID EXTRACTION;
MATRIX EFFECT;
QUANTITATION;
LIQUID CHROMATOGRAPHY;
4 [3 [6 AMINO 9 (5 ETHYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDRO 2 FURYL) 9H PURIN 2 YL] 2 PROPYNYL]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER;
ADENOSINE A2 RECEPTOR AGONIST;
DRUG METABOLITE;
DYFLOS;
ESTER DERIVATIVE;
ESTERASE INHIBITOR;
TERT BUTYL METHYL ETHER;
ACIDIFICATION;
ARTICLE;
BLOOD SAMPLING;
DRUG DETERMINATION;
DRUG STABILITY;
DRUG STRUCTURE;
ELECTROSPRAY MASS SPECTROMETRY;
HUMAN;
HUMAN CELL;
LIQUID CHROMATOGRAPHY;
LIQUID LIQUID EXTRACTION;
PRIORITY JOURNAL;
QUALITY CONTROL;
TANDEM MASS SPECTROMETRY;
VALIDATION PROCESS;
ALKYNES;
CALIBRATION;
CHROMATOGRAPHY, LIQUID;
ENZYME INHIBITORS;
ESTERASES;
ESTERS;
HUMANS;
ISOFLUROPHATE;
PURINE NUCLEOSIDES;
RECEPTORS, PURINERGIC P1;
REFERENCE STANDARDS;
REPRODUCIBILITY OF RESULTS;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
TANDEM MASS SPECTROMETRY;
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EID: 34249652463
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2006.12.054 Document Type: Article |
Times cited : (25)
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References (14)
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