LC-MS/MS determination of betamethasone and its phosphate and acetate esters in human plasma after sample stabilization

Journal of Pharmaceutical and Biomedical Analysis

Volumn 56, Issue 5, 2011, Pages 983-991

  Salem, Isam I ^a   Alkhatib, Musab ^a   Najib, Naji ^a  

^a International Pharmaceutical Research Center Amman   (Jordan)

Author keywords

Betamethasone; Esters; LC MS MS; Pharmacokinetics; Stabilized plasma

Indexed keywords

ACETATE ESTER; BETAMETHASONE; BETAMETHASONE SODIUM PHOSPHATE; ESTER DERIVATIVE; PREDNISOLONE; PREDNISOLONE 21 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; ELECTROSPRAY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PLASMA; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ACETATES; BETAMETHASONE; CHROMATOGRAPHY, LIQUID; ESTERS; GLUCOCORTICOIDS; HUMANS; LIMIT OF DETECTION; PHOSPHATES; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 80052814011     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.07.020     Document Type: Article

References (21)

1. Physician's Desk Reference (PDR), http://www.pdr.net/search/searchResult.aspx%3FsearchCriteria=betamethasone.
2. Martindale The Complete Drug Reference 2004, Pharmaceutical Press, London, UK, (Electronic version). 34th edition.
3. Petersen M.C., Nation R.L., Ashley J.J. Simultaneous determination of betamethasone, betamethasone acetate and hydrocortisone in biological fluids using high performance liquid chromatography. J. Chromatogr. 1980, 183:131-139.
4. Cheng W.S., Chen J.L., Chiang C.H. Simultaneous determination of plasma betamethasone disodium phosphate and betamethasone in rabbit by high performance liquid chromatography. J. Food Drug Anal. 2009, 17:348-356.
5. Samtani M.N., Schwab M., Nathanielsz P.W., Jusko W.J. Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma. J. Pharm. Sci. 2004, 93:726-732.
6. Rodchenkov G.M., Uralets V.P., Semenov V.A., Gurevich V.A. Gas chromatographic and mass spectral study of betamethasone synthetic corticosteroid metabolism. J. Chromatogr. 1988, 432:283-289.
7. Watson D.G., McGhee C.N., Midgley J.M., Dutton G.N., Noble M.J. Penetration of topically applied betamethasone sodium phosphate into human aqueous humour. Eye (Lond.) 1990, 4:603-606.
8. Zou J.J., Dai L., Ding L., Xiao D.W., Bin Z.Y., Fan H.W., Liu L., Wang G.J. Determination of betamethasone and betamethasone 17-monopropionate in human plasma by liquid chromatography-positive/negative electrospray ionization tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2008, 873:159-164.
9. Qu T.T., Zhang R., Wang B.J., Liu X.Y., Yuan G.Y., Guo R.C. Determination of betamethasone in human plasma by liquid chromatography with tandem mass. Yao Xue Xue Bao 2008, 43:402-407.
10. Chen D., Tao Y., Liu Z., Zhang H., Liu Z., Wang Y., Huang L., Pan Y., Peng D. Development of a liquid chromatography-tandem mass spectrometry with pressurized liquid extraction for determination of glucocorticoid residues in edible tissues. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2011, 879:174-180.
11. Chen D., Tao Y., Liu Z., Liu Z., Wang Y., Huang L., Yuan Z. Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken. Food Addit. Contam. A: Chem. Anal. Control Expo. Risk Assess. 2010, 10:1363-1371.
12. Andersen J.H., Hansen L.G., Pedersen M. Optimization of solid phase extraction clean up and validation of quantitative determination of corticosteroids in urine by liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 2008, 617:216-224.
13. Samtani M.N., Lohle M., Grant A., Nathanielsz P.W., Jusko W.J. Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metab. Dispos. 2005, 33:1124-1130.
14. Oueslati F., Ben Hamida N., Toumi A., Trabelsi H. Effect of organic modifier and temperature on the resolution of betamethasone and dexamethasone using a porous graphitic carbon column: application to their identification and confirmation in human urine by LC-ESI-MS/MS. J. Sep. Sci. 2007, 18:3137-3142.
15. Malone E.M., Elliott C.T., Kennedy D.G., Regan L. Screening and quantitative confirmatory method for the analysis of glucocorticoids in bovine milk using liquid chromatography-tandem mass spectrometry. J. AOAC Int. 2010, 93:1656-1665.
16. Li C., Wu Y., Yang T., Zhang Y. Rapid simultaneous determination of dexamethasone and betamethasone in milk by liquid chromatography tandem mass spectrometry with isotope dilution. J. Chromatogr. A 2010, 1217:411-414.
17. Malone E.M., Dowling G., Elliott C.T., Kennedy D.G., Regan L. Development of a rapid, multi-class method for the confirmatory analysis of anti-inflammatory drugs in bovine milk using liquid chromatography tandem mass spectrometry. J. Chromatogr. A 2009, 1216:8132-8140.
18. Li M., Wang X., Chen B., Lin M., Buevich A.V., Chan T.M., Rustum A.M. Use of liquid chromatography/tandem mass spectrometric molecular fingerprinting for the rapid structural identification of pharmaceutical impurities. Rapid Commun. Mass Spectrom. 2009, 22:3533-3542.
19. Li M., Lin M., Rustum A. Application of LC-MS(n) in conjunction with mechanism-based stress studies in the elucidation of drug impurity structure: rapid identification of a process impurity in betamethasone 17-valerate drug substance. J. Pharm. Biomed. Anal. 2008, 48:1451-1456.
20. Willoughby R., Sheehan E., Mitrovich S. A global view of LC/MS 2002, Global View Publishing, Pittsburgh, PA. 2nd edition.
21. Guidance for Industry. Bioanalytical Method Validation 2001, US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER).