Enhancement of Oral Tolerance Induction in DO11.10 Mice by Lactobacillus gasseri OLL2809 via Increase of Effector Regulatory T Cells

PLoS ONE

Volumn 11, Issue 7, 2016, Pages

  Aoki Yoshida, Ayako ^a,b   Yamada, Kiyoshi ^a   Hachimura, Satoshi ^a   Sashihara, Toshihiro ^c   Ikegami, Shuji ^c   Shimizu, Makoto ^a   Totsuka, Mamoru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF LIVESTOCK AND GRASSLAND SCIENCE   (Japan)

^c MEIJI DAIRIES CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2; LEUKOCYTE ANTIGEN; OVALBUMIN;

ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LACTOBACILLUS; MOUSE; ORAL DRUG ADMINISTRATION; REGULATORY T LYMPHOCYTE; TRANSGENIC MOUSE;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-2; LACTOBACILLUS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OVALBUMIN; T-LYMPHOCYTES, REGULATORY;

EID: 85019280297     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0158643     Document Type: Article

References (70)

1. FAO/WHO, editor Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food.2002 April 30, May 1; Ontario, Canada.
2. Cong Y, Konrad A, Iqbal N, Elson CO. Probiotics and immune regulation of inflammatory bowel diseases. Curr Drug Targets Inflamm Allergy. 2003; 2(2):145–54. Epub 2003/10/17. PMID: 14561167.
3. Isolauri E, Kirjavainen PV, Salminen S. Probiotics: a role in the treatment of intestinal infection and inflammation? Gut. 2002; 50 Suppl 3:III54–9. Epub 2002/04/16. PMID: 11953334; PubMed Central PMCID: PMC1867676.
4. Sashihara T, Sueki N, Ikegami S. An analysis of the effectiveness of heat-killed lactic acid bacteria in alleviating allergic diseases. J Dairy Sci. 2006; 89(8):2846–55. Epub 2006/07/15. S0022-0302(06) 72557-7 [pii] doi: 10.3168/jds.S0022-0302(06)72557-7 PMID: 16840600.
5. Gotoh M, Sashihara T, Ikegami S, Yamaji T, Kino K, Orii N, et al. Efficacy of oral administration of a heat-killed Lactobacillus gasseri OLL2809 on patients of Japanese cedar pollinosis with high Japanese-cedar pollen-specific IgE. Biosci Biotechnol Biochem. 2009; 73(9):1971–7. Epub 2009/09/08. JST.JSTAGE/bbb/90144 [pii]. PMID: 19734682.
6. Sashihara T, Ikegami S, Sueki N, Yamaji T, Kino K, Taketomo N, et al. Oral administration of heat-killed Lactobacillus gasseri OLL2809 reduces cedar pollen antigen-induced peritoneal eosinophilia in Mice. Allergol Int. 2008; 57(4):397–403. Epub 2008/10/24. 057040397 [pii] doi: 10.2332/allergolint.O-08-541 PMID: 18946235.
7. Sashihara T, Sueki N, Furuichi K, Ikegami S. Effect of growth conditions of Lactobacillus gasseri OLL2809 on the immunostimulatory activity for production of interleukin-12 (p70) by murine splenocytes. Int J Food Microbiol. 2007; 120(3):274–81. Epub 2007/10/16. S0168-1605(07)00509-0 [pii] doi: 10.1016/j.ijfoodmicro.2007.09.003 PMID: 17936392.
8. Yoshida A, Yamada K, Yamazaki Y, Sashihara T, Ikegami S, Shimizu M, et al. Lactobacillus gasseri OLL2809 and its RNA suppress proliferation of CD4(+) T cells through a MyD88-dependent signalling pathway. Immunology. 2011; 133(4):442–51. Epub 2011/06/02. doi: 10.1111/j.1365-2567.2011.03455. x PMID: 21627651; PubMed Central PMCID: PMCPMC3143356.
9. Zeiger RS. Food allergen avoidance in the prevention of food allergy in infants and children. Pediatrics. 2003; 111(6 Pt 3):1662–71. Epub 2003/06/05. PMID: 12777607.
10. Isolauri E, Sutas Y, Salo MK, Isosomppi R, Kaila M. Elimination diet in cow's milk allergy: risk for impaired growth in young children. The Journal of pediatrics. 1998; 132(6):1004–9. Epub 1998/06/17. PMID: 9627594.
11. Hahn EL, Bacharier LB. The atopic march: the pattern of allergic disease development in childhood. Immunology and allergy clinics of North America. 2005; 25(2):231–46, v. Epub 2005/05/10. doi: 10. 1016/j.iac.2005.02.004 PMID: 15878453.
12. Faria AM, Weiner HL. Oral tolerance: therapeutic implications for autoimmune diseases. Clin Dev Immunol. 2006; 13(2–4):143–57. Epub 2006/12/13. doi: 10.1080/17402520600876804. PMID: 17162357; PubMed Central PMCID: PMCPmc2270752.
13. Tang ML, Martino DJ. Oral immunotherapy and tolerance induction in childhood. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2013; 24 (6):512–20. Epub 2013/08/03. doi: 10.1111/pai.12100 PMID: 23905867.
14. Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, et al. Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Mod Rheumatol. 2009; 19(6):581–9. Epub 2009/08/22. doi: 10.1007/s10165-009-0210-0 PMID: 19697097.
15. Hirahara K, Hisatsune T, Nishijima K, Kato H, Shiho O, Kaminogawa S. CD4+ T cells anergized by high dose feeding establish oral tolerance to antibody responses when transferred in SCID and nude mice. J Immunol. 1995; 154(12):6238–45. Epub 1995/06/15. PMID: 7759861.
16. Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 1995; 376(6536):177–80. Epub 1995/07/13. doi: 10.1038/376177a0 PMID: 7603570.
17. Laegreid A, Thommesen L, Jahr TG, Sundan A, Espevik T. Tumor necrosis factor induces lipopolysaccharide tolerance in a human adenocarcinoma cell line mainly through the TNF p55 receptor. J Biol Chem. 1995; 270(43):25418–25. Epub 1995/10/27. PMID: 7592709.
18. Martin P, Del Hoyo GM, Anjuere F, Arias CF, Vargas HH, Fernandez LA, et al. Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood. 2002; 100(2):383–90. Epub 2002/07/02. PMID: 12091326.
19. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994; 265(5176):1237–40. Epub 1994/ 08/26. PMID: 7520605.
20. Shiokawa A, Tanabe K, Tsuji NM, Sato R, Hachimura S. IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance. Immunol Lett. 2009; 125 (1):7–14. Epub 2009/05/19. S0165-2478(09)00117-5 [pii] doi: 10.1016/j.imlet.2009.05.002 PMID: 19446579.
21. Chang JH, Lee JM, Youn HJ, Lee KA, Chung Y, Lee AY, et al. Functional maturation of lamina propria dendritic cells by activation of NKT cells mediates the abrogation of oral tolerance. Eur J Immunol. 2008; 38(10):2727–39. Epub 2008/10/01. doi: 10.1002/eji.200838159 PMID: 18825753.
22. Goubier A, Dubois B, Gheit H, Joubert G, Villard-Truc F, Asselin-Paturel C, et al. Plasmacytoid dendritic cells mediate oral tolerance. Immunity. 2008; 29(3):464–75. Epub 2008/09/16. S1074-7613(08)00372-5 [pii] doi: 10.1016/j.immuni.2008.06.017 PMID: 18789731.
23. Min SY, Park KS, Cho ML, Kang JW, Cho YG, Hwang SY, et al. Antigen-induced, tolerogenic CD11c+, CD11b+ dendritic cells are abundant in Peyer's patches during the induction of oral tolerance to type II collagen and suppress experimental collagen-induced arthritis. Arthritis Rheum. 2006; 54(3):887–98. Epub 2006/03/02. doi: 10.1002/art.21647 PMID: 16508971.
24. Worbs T, Bode U, Yan S, Hoffmann MW, Hintzen G, Bernhardt G, et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med. 2006; 203 (3):519–27. Epub 2006/03/15. jem.20052016 [pii] doi: 10.1084/jem.20052016 PMID: 16533884; PubMed Central PMCID: PMC2118247.
25. Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature. 2007; 449(7161):419–26. Epub 2007/09/28. nature06175 [pii] doi: 10.1038/nature06175 PMID: 17898760.
26. Bilsborough J, George TC, Norment A, Viney JL. Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties. Immunology. 2003; 108(4):481–92. Epub 2003/04/02. 1606 [pii]. PMID: 12667210; PubMed Central PMCID: PMC1782923.
27. Wang X, O'Gorman MR, Bu HF, Koti V, Zuo XL, Tan XD. Probiotic preparation VSL#3 alters the distribution and phenotypes of dendritic cells within the intestinal mucosa in C57BL/10J mice. J Nutr. 2009; 139(8):1595–602. Epub 2009/06/25. jn.109.109934 [pii] doi: 10.3945/jn.109.109934 PMID: 19549755; PubMed Central PMCID: PMC2709306.
28. Skripak JM, Nash SD, Rowley H, Brereton NH, Oh S, Hamilton RG, et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol. 2008; 122(6):1154–60. Epub 2008/10/28. S0091-6749(08)01725-9 [pii] doi: 10.1016/j.jaci.2008.09.030 PMID: 18951617.
29. Boonstra A, Asselin-Paturel C, Gilliet M, Crain C, Trinchieri G, Liu YJ, et al. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med. 2003; 197(1):101–9. Epub 2003/01/08. PMID: 12515817; PubMed Central PMCID: PMC2193804.
30. Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007; 204(8):1757–64. Epub 2007/07/11. jem.20070590 [pii] doi: 10.1084/jem.20070590 PMID: 17620361; PubMed Central PMCID: PMC2118683.
31. Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007; 204 (8):1775–85. Epub 2007/07/11. doi: 10.1084/jem.20070602 PMID: 17620362; PubMed Central PMCID: PMC2118682.
32. Wu L, Liu YJ. Development of dendritic-cell lineages. Immunity. 2007; 26(6):741–50. Epub 2007/06/22. doi: 10.1016/j.immuni.2007.06.006 PMID: 17582346.
33. Lackey DE, Ashley SL, Davis AL, Hoag KA. Retinoic acid decreases adherence of murine myeloid dendritic cells and increases production of matrix metalloproteinase-9. J Nutr. 2008; 138(8):1512–9. Epub 2008/07/22. 138/8/1512 [pii]. PMID: 18641199; PubMed Central PMCID: PMC2522314.
34. Ren Z, Guo Z, Meydani SN, Wu D. White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice. J Nutr. 2008; 138(3):544–50. Epub 2008/02/22. 138/3/544 [pii]. PMID: 18287364.
35. Szeles L, Keresztes G, Torocsik D, Balajthy Z, Krenacs L, Poliska S, et al. 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. J Immunol. 2009; 182(4):2074–83. Epub 2009/02/10. 182/4/2074 [pii] doi: 10.4049/jimmunol. 0803345 PMID: 19201860.
36. Moreau MC, Gaboriau-Routhiau V. The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice. Res Immunol. 1996; 147(1):49–59. Epub 1996/01/01. 0923249496815483 [pii]. PMID: 8739328.
37. Prioult G, Fliss I, Pecquet S. Effect of probiotic bacteria on induction and maintenance of oral tolerance to beta-lactoglobulin in gnotobiotic mice. Clin Diagn Lab Immunol. 2003; 10(5):787–92. Epub 2003/09/ 11. PMID: 12965905; PubMed Central PMCID: PMC193892.
38. Maeda Y, Noda S, Tanaka K, Sawamura S, Aiba Y, Ishikawa H, et al. The failure of oral tolerance induction is functionally coupled to the absence of T cells in Peyer's patches under germfree conditions. Immunobiology. 2001; 204(4):442–57. Epub 2002/01/05. PMID: 11776399.
39. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol. 1997; 159(4):1739–45. Epub 1997/08/15. PMID: 9257835.
40. Wannemuehler MJ, Kiyono H, Babb JL, Michalek SM, McGhee JR. Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction. J Immunol. 1982; 129(3):959–65. Epub 1982/09/01. PMID: 6980928.
41. So JS, Lee CG, Kwon HK, Yi HJ, Chae CS, Park JA, et al. Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis. Mol Immunol. 2008; 46(1):172–80. Epub 2008/09/23. S0161-5890(08)00598-1 [pii] doi: 10.1016/j.molimm.2008.07.038 PMID: 18804867.
42. Tsai YT, Cheng PC, Fan CK, Pan TM. Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101. Int J Food Microbiol. 2008; 128(2):219–25. Epub 2008/09/24. S0168-1605(08)00456-X [pii] doi: 10.1016/j.ijfoodmicro.2008. 08.009 PMID: 18809220.
43. de Moreno de LeBlanc A, Dogi CA, Galdeano CM, Carmuega E, Weill R, Perdigon G. Effect of the administration of a fermented milk containing Lactobacillus casei DN-114001 on intestinal microbiota and gut associated immune cells of nursing mice and after weaning until immune maturity. BMC Immunol. 2008; 9:27. Epub 2008/06/17. 1471-2172-9-27 [pii] doi: 10.1186/1471-2172-9-27 PMID: 18554392; PubMed Central PMCID: PMC2459154.
44. Murphy KM, Heimberger AB, Loh DY. Induction by antigen of intrathymic apoptosis of CD4+CD8 +TCRlo thymocytes in vivo. Science. 1990; 250(4988):1720–3. Epub 1990/12/21. PMID: 2125367.
45. Ise W, Totsuka M, Sogawa Y, Ametani A, Hachimura S, Sato T, et al. Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen. J Immunol. 2002; 168(7):3242–50. Epub 2002/03/22. PMID: 11907078.
46. Ise W, Totsuka M, Takato R, Hachimura S, Sato T, Ametani A, et al. Primary response of naive CD4(+) T cells to amino acid-substituted analogs of an antigenic peptide can show distinct activation patterns: Th1- and Th2-type cytokine secretion, and helper activity for antibody production without apparent cytokine secretion. FEBS Lett. 2000; 465(1):28–33. Epub 2000/01/06. S0014-5793(99)01716-0 [pii]. PMID: 10620701.
47. Yoshida A, Aoki R, Kimoto-Nira H, Kobayashi M, Kawasumi T, Mizumachi K, et al. Oral administration of live Lactococcus lactis C59 suppresses IgE antibody production in ovalbumin-sensitized mice via the regulation of interleukin-4 production. FEMS Immunol Med Microbiol. 2011; 61(3):315–22. Epub 2011/ 01/06. doi: 10.1111/j.1574-695X.2010.00777.x PMID: 21205006.
48. Tsuji NM, Mizumachi K, Kurisaki J. Interleukin-10-secreting Peyer's patch cells are responsible for active suppression in low-dose oral tolerance. Immunology. 2001; 103(4):458–64. Epub 2001/09/01. imm1265 [pii]. PMID: 11529936; PubMed Central PMCID: PMC1783258.
49. Battaglia M, Gianfrani C, Gregori S, Roncarolo MG. IL-10-producing T regulatory type 1 cells and oral tolerance. Annals of the New York Academy of Sciences. 2004; 1029:142–53. Epub 2005/02/01. doi: 10.1196/annals.1309.031 PMID: 15681753.
50. Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007; 179(6):3724–33. Epub 2007/09/06. 179/6/3724 [pii]. PMID: 17785809.
51. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science. 2007; 317(5835):256–60. Epub 2007/06/16. 1145697 [pii] doi: 10.1126/science.1145697 PMID: 17569825.
52. Michalek SM, Kiyono H, Wannemuehler MJ, Mosteller LM, McGhee JR. Lipopolysaccharide (LPS) regulation of the immune response: LPS influence on oral tolerance induction. J Immunol. 1982; 128 (5):1992–8. Epub 1982/05/01. PMID: 6460815.
53. Tanaka K, Ishikawa H. Role of intestinal bacterial flora in oral tolerance induction. Histol Histopathol. 2004; 19(3):907–14. Epub 2004/05/29. PMID: 15168353.
54. Bradley LM, Atkins GG, Swain SL. Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor. J Immunol. 1992; 148(2):324–31. Epub 1992/01/15. PMID: 1345918.
55. DeGrendele HC, Estess P, Siegelman MH. Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science. 1997; 278(5338):672–5. Epub 1997/10/24. PMID: 9381175.
56. Wittmann A, Autenrieth IB, Frick JS. Plasmacytoid dendritic cells are crucial in Bifidobacterium adolescentis-mediated inhibition of Yersinia enterocolitica infection. PloS one. 2013; 8(8):e71338. Epub 2013/ 08/27. doi: 10.1371/journal.pone.0071338 PMID: 23977019; PubMed Central PMCID: PMCPMC3748105.
57. Diana J, Griseri T, Lagaye S, Beaudoin L, Autrusseau E, Gautron AS, et al. NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner. Immunity. 2009; 30 (2):289–99. Epub 2009/02/17. doi: 10.1016/j.immuni.2008.12.017 PMID: 19217323.
58. Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, et al. Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol. 2011; 12(10):966–74. Epub 2011/09/06. doi: 10.1038/ni.2096 PMID: 21892173; PubMed Central PMCID: PMCPmc3178673.
59. Ashour HM, Seif TM. The role of B cells in the induction of peripheral T cell tolerance. Journal of leukocyte biology. 2007; 82(5):1033–9. Epub 2007/07/28. doi: 10.1189/jlb.0507310 PMID: 17656652.
60. Ashour HM, Niederkorn JY. Expansion of B cells is necessary for the induction of T-cell tolerance elicited through the anterior chamber of the eye. Int Arch Allergy Immunol. 2007; 144(4):343–6. Epub 2007/08/03. doi: 10.1159/000106461 PMID: 17671393.
61. Peng HJ, Chang ZN, Lee CC, Kuo SW. B-cell depletion fails to abrogate the induction of oral tolerance of specific Th1 immune responses in mice. Scandinavian journal of immunology. 2000; 51(5):454–60. Epub 2000/05/03. PMID: 10792836.
62. Sun JB, Flach CF, Czerkinsky C, Holmgren J. B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B subunit. J Immunol. 2008; 181(12):8278–87. Epub 2008/12/04. PMID: 19050244.
63. Carter NA, Rosser EC, Mauri C. Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Res Ther. 2012; 14(1):R32. Epub 2012/02/10. doi: 10.1186/ar3736 PMID: 22315945; PubMed Central PMCID: PMCPmc3392827.
64. Bhattacharya P, Fan J, Haddad C, Essani A, Gopisetty A, Elshabrawy HA, et al. A novel pancreatic beta-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice. Clinical immunology (Orlando, Fla). 2014; 153(1):187–98. Epub 2014/05/06. doi: 10.1016/j.clim. 2014.04.014 PMID: 24792135; PubMed Central PMCID: PMCPmc4077286.
65. Buckland J. Rheumatoid arthritis: Anti-TNF and anti-IL-17 antibodies—better together! Nature reviews Rheumatology. 2014; 10(12):699. Epub 2014/10/29. doi: 10.1038/nrrheum.2014.183 PMID: 25348041.
66. Li Q, Ren G, Xu L, Wang Q, Qi J, Wang W, et al. Therapeutic efficacy of three bispecific antibodies on collagen-induced arthritis mouse model. Int Immunopharmacol. 2014; 21(1):119–27. Epub 2014/05/08. doi: 10.1016/j.intimp.2014.04.018 PMID: 24800661.
67. Thiruppathi M, Sheng JR, Li L, Prabhakar BS, Meriggioli MN. Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis. Journal of autoimmunity. 2014; 52:64–73. Epub 2014/01/07. doi: 10.1016/j.jaut.2013.12.014 PMID: 24388113; PubMed Central PMCID: PMCPmc4518541.
68. Lan Q, Fan H, Quesniaux V, Ryffel B, Liu Z, Zheng SG. Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? Journal of molecular cell biology. 2012; 4(1):22–8. Epub 2011/11/24. doi: 10.1093/jmcb/mjr039 PMID: 22107826; PubMed Central PMCID: PMCPmc3491614.
69. Zeng H, Zhang R, Jin B, Chen L. Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance. Cellular & molecular immunology. 2015; 12(5):566–71. Epub 2015/06/09. doi: 10.1038/cmi. 2015.44 PMID: 26051475; PubMed Central PMCID: PMCPmc4579656.
70. Jin JO, Han X, Yu Q. Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. Journal of autoimmunity. 2013; 40:28–44. Epub 2012/08/28. doi: 10. 1016/j.jaut.2012.07.009 PMID: 22921334; PubMed Central PMCID: PMCPmc3524403.