Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

Science

Volumn 356, Issue 6338, 2017, Pages 608-616

  Grillo, Anthony S ^a   SantaMaria, Anna M ^b   Kafina, Martin D ^c   Cioffi, Alexander G ^b   Huston, Nicholas C ^c   Han, Murui ^d   Seo, Young Ah ^e   Yien, Yvette Y ^c   Nardone, Christopher ^b   Menon, Archita V ^d   Fan, James ^a   Svoboda, Dillon C ^b   Anderson, Jacob B ^a   Hong, John D ^a   Nicolau, Bruno G ^a   Subedi, Kiran ^a   Gewirth, Andrew A ^a   Wessling Resnick, Marianne ^f   Kim, Jonghan ^d   Paw, Barry H ^c,g,h   Burke, Martin D ^a,b,i   more..

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NORTHEASTERN UNIVERSITY   (United States)

^e UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN; HEMOGLOBIN; IRON; MITOFERRIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; THUJAPLICIN; UNCLASSIFIED DRUG; BETA-THUJAPLICIN; IRON BINDING PROTEIN; TERPENE; TROPOLONE;

ABSORPTION; ANIMAL; CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; DISEASE TREATMENT; IRON; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HOMEOSTASIS; IRON ABSORPTION; IRON BINDING CAPACITY; IRON TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; ZEBRA FISH; ANALOGS AND DERIVATIVES; ANIMAL; CACO-2 CELL LINE; GASTROINTESTINAL ABSORPTION; HUMAN; METABOLISM; SACCHAROMYCES CEREVISIAE;

ANIMALIA; DANIO RERIO; MUS; RATTUS;

ANIMALS; CACO-2 CELLS; GASTROINTESTINAL ABSORPTION; HEMOGLOBINS; HUMANS; IRON; IRON-BINDING PROTEINS; MONOTERPENES; RATS; SACCHAROMYCES CEREVISIAE; TROPOLONE;

EID: 85019221466     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah3862     Document Type: Article

References (52)

1. E. Gouaux, R. Mackinnon, Science 310, 1461-1465 (2005).
2. M. W. Hentze, M. U. Muckenthaler, B. Galy, C. Camaschella, Cell 142, 24-38 (2010).
3. V. S. Shah et al., Science 351, 503-507 (2016).
4. F. Yi et al., Science 352, aaf2669 (2016).
5. P. Imbrici et al., Front. Pharmacol. 7, 121 (2016).
6. N. C. Andrews, Nat. Rev. Genet. 1, 208-217 (2000).
7. N. C. Andrews, N. Engl. J. Med. 341, 1986-1995 (1999).
8. P. T. Lieu, M. Heiskala, P. A. Peterson, Y. Yang, Mol. Aspects Med. 22, 1-87 (2001).
9. G. Weiss, L. T. Goodnough, N. Engl. J. Med. 352, 1011-1023 (2005).
10. G. C. Shaw et al., Nature 440, 96-100 (2006).
11. J. Chung et al., J. Biol. Chem. 289, 7835-7843 (2014).
12. A. Donovan et al., Nature 403, 776-781 (2000).
13. A. T. McKie et al., Mol. Cell 5, 299-309 (2000).
14. I. E. Zohn et al., Blood 109, 4174-4180 (2007).
15. Y. A. Seo, M. Wessling-Resnick, FASEB J. 29, 2726-2733 (2015).
16. Y. S. Sohn, W. Breuer, A. Munnich, Z. I. Cabantchik, Blood 111, 1690-1699 (2008).
17. H. C. Hatcher, R. N. Singh, F. M. Torti, S. V. Torti, Future Med. Chem. 1, 1643-1670 (2009).
18. X. P. Huang, M. Spino, J. J. Thiessen, Pharm. Res. 23, 280-290 (2006).
19. J. L. Buss, M. Hermes-Lima, P. Ponka, Adv. Exp. Med. Biol. 509, 205-229 (2002).
20. A. G. Cioffi, J. Hou, A. S. Grillo, K. A. Diaz, M. D. Burke, J. Am. Chem. Soc. 137, 10096-10099 (2015).
21. M. R. Bleackley, R. T. A. Macgillivray, Biometals 24, 785-809 (2011).
22. T. Nozoe, Bull. Chem. Soc. Jpn. 11, 295-298 (1936).
23. B. E. Bryant, W. C. Fernelius, J. Am. Chem. Soc. 76, 1696-1697 (1954).
24. M. C. Barret, M. F. Mahon, K. C. Molloy, J. W. Steed, P. Wright, Inorg. Chem. 40, 4384-4388 (2001).
25. K. Nomiya et al., J. Inorg. Biochem. 98, 46-60 (2004).
26. K. Nomiya et al., Inorg. Chim. Acta 362, 43-55 (2009).
27. C. Meck, M. P. D'Erasmo, D. R. Hirsch, R. P. Murelli, MedChemComm 5, 842-852 (2014).
28. Y. Ido et al., Cell Prolif. 32, 63-73 (1999).
29. K. Murakami, Y. Ohara, M. Haneda, R. Tsubouchi, M. Yoshino, Basic Clin. Pharmacol. Toxicol. 97, 392-394 (2005).
30. M. J. Lee, J. W. Kim, E. G. Yang, Biochem. Biophys. Res. Commun. 396, 370-375 (2010).
31. G. Böhme, P. Schönfeld, U. Küster, W. Kunz, H. Lyr, Acta Biol. Med. Ger. 39, 1153-1163 (1980).
32. G. Ghssein et al., Science 352, 1105-1109 (2016).
33. L. A. Finney, T. V. O'Halloran, Science 300, 931-936 (2003).
34. L. A. Ba, M. Doering, T. Burkholz, C. Jacob, Metallomics 1, 292-311 (2009).
35. M. S. Cyert, C. C. Philpott, Genetics 193, 677-713 (2013).
36. A. Espinoza et al., Biol. Trace Elem. Res. 146, 281-286 (2012).
37. I. Hubatsch, E. G. E. Ragnarsson, P. Artursson, Nat. Protoc. 2, 2111-2119 (2007).
38. M. Tabuchi, T. Yoshimori, K. Yamaguchi, T. Yoshida, F. Kishi, J. Biol. Chem. 275, 22220-22228 (2000).
39. C. Friend, W. Scher, J. G. Holland, T. Sato, Proc. Natl. Acad. Sci. U.S.A. 68, 378-382 (1971).
40. M. Lesjak et al., PLOS ONE 9, e102900 (2014).
41. M. D. Knutson, M. Oukka, L. M. Koss, F. Aydemir, M. Wessling-Resnick, Proc. Natl. Acad. Sci. U.S.A. 102, 1324-1328 (2005).
42. B. P. Espósito, W. Breuer, Z. I. Cabantchik, Biochem. Soc. Trans. 30, 729-732 (2002).
43. Y. S. Sohn et al., Haematologica 97, 670-678 (2012).
44. M. Arredondo, A. Orellana, M. A. Gárate, M. T. Núñez, Am. J. Physiol. 273, G275-G280 (1997).
45. D. L. Zhang, R. M. Hughes, H. Ollivierre-Wilson, M. C. Ghosh, T. A. Rouault, Cell Metab. 9, 461-473 (2009).
46. N. Imai et al., J. Toxicol. Sci. 31, 357-370 (2006).
47. T. Veuthey, M. Wessling-Resnick, Front. Pharmacol. 5, 82(2014).
48. S. Avagyan, L. I. Zon, Hum. Gene Ther. 27, 287-294 (2016).
49. A. Donovan et al., Blood 100, 4655-4659 (2002).
50. J. J. Ganis et al., Dev. Biol. 366, 185-194 (2012).
51. A. Brownlie et al., Nat. Genet. 20, 244-250 (1998).
52. C. Miller, Nature 440, 484-489 (2006).