-
2
-
-
2942616383
-
Purging iron from the heart
-
Hershko C, Cappellini MD, Galanello R, Piga A, Tognoni G, Masera G. Purging iron from the heart. Br J Haematol. 2004;125:545-551.
-
(2004)
Br J Haematol
, vol.125
, pp. 545-551
-
-
Hershko, C.1
Cappellini, M.D.2
Galanello, R.3
Piga, A.4
Tognoni, G.5
Masera, G.6
-
3
-
-
14944387002
-
Iron trafficking in the mitochondrion: Novel pathways revealed by disease
-
Napier I, Ponka P, Richardson DR. Iron trafficking in the mitochondrion: novel pathways revealed by disease. Blood. 2005;105:1867-1874.
-
(2005)
Blood
, vol.105
, pp. 1867-1874
-
-
Napier, I.1
Ponka, P.2
Richardson, D.R.3
-
4
-
-
33750706562
-
Iron dysregulation in Friedreich ataxia
-
Wilson RB. Iron dysregulation in Friedreich ataxia. Semin Pediatr Neurol. 2006;13:166-175.
-
(2006)
Semin Pediatr Neurol
, vol.13
, pp. 166-175
-
-
Wilson, R.B.1
-
5
-
-
33750735406
-
Neurodegeneration with brain iron accumulation: From genes to pathogenesis
-
Hayflick SJ. Neurodegeneration with brain iron accumulation: from genes to pathogenesis. Semin Pediatr Neurol. 2006;13:182-185.
-
(2006)
Semin Pediatr Neurol
, vol.13
, pp. 182-185
-
-
Hayflick, S.J.1
-
6
-
-
30944445397
-
Neurodegeneration with brain iron accumulation
-
Gregory A, Hayflick SJ. Neurodegeneration with brain iron accumulation. Folia Neuropathol. 2005;43:286-296.
-
(2005)
Folia Neuropathol
, vol.43
, pp. 286-296
-
-
Gregory, A.1
Hayflick, S.J.2
-
7
-
-
33645314044
-
Molecular pathogenesis of anemia of chronic disease
-
Ganz T. Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer. 2006;46:554-557.
-
(2006)
Pediatr Blood Cancer
, vol.46
, pp. 554-557
-
-
Ganz, T.1
-
8
-
-
0041672570
-
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
-
Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102:783-788.
-
(2003)
Blood
, vol.102
, pp. 783-788
-
-
Ganz, T.1
-
9
-
-
14744278436
-
Anemia of chronic disease
-
Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011-1023.
-
(2005)
N Engl J Med
, vol.352
, pp. 1011-1023
-
-
Weiss, G.1
Goodnough, L.T.2
-
10
-
-
0037546454
-
Iron chelator chemistry
-
Templeton DM, ed, New York, NY: Marcel Dekker;
-
Liu ZD, Hider RC. Iron chelator chemistry. In Templeton DM, ed. Molecular and Cellular Iron Transport. New York, NY: Marcel Dekker; 2002:321-357.
-
(2002)
Molecular and Cellular Iron Transport
, pp. 321-357
-
-
Liu, Z.D.1
Hider, R.C.2
-
11
-
-
0035254193
-
Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy
-
Breuer W, Ermers MJ, Pootrakul P, Abramov A, Hershko C, Cabantchik ZI. Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy. Blood. 2001;97:792-798.
-
(2001)
Blood
, vol.97
, pp. 792-798
-
-
Breuer, W.1
Ermers, M.J.2
Pootrakul, P.3
Abramov, A.4
Hershko, C.5
Cabantchik, Z.I.6
-
12
-
-
0027080322
-
The effect of alpha-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo
-
Evans RW, Sharma M, Ogwang W, Patel KJ, Bartlett AN, Kontoghiorghes GJ. The effect of alpha-ketohydroxypyridine chelators on transferrin saturation in vitro and in vivo. Drugs Today (Barc). 1992;28:19-23.
-
(1992)
Drugs Today (Barc)
, vol.28
, pp. 19-23
-
-
Evans, R.W.1
Sharma, M.2
Ogwang, W.3
Patel, K.J.4
Bartlett, A.N.5
Kontoghiorghes, G.J.6
-
13
-
-
34347370842
-
Selective iron chelation in Friedreich ataxia. Biological and clinical implications
-
Boddaert N, Le Quan Sang KH, Rötig A, et al. Selective iron chelation in Friedreich ataxia. Biological and clinical implications. Blood. 2007;110:401-408.
-
(2007)
Blood
, vol.110
, pp. 401-408
-
-
Boddaert, N.1
Le Quan Sang, K.H.2
Rötig, A.3
-
14
-
-
0027175998
-
Inhibition of catechol-O- methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo
-
Waldmeier PC, Buchle AM, Steulet AF. Inhibition of catechol-O- methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo. Biochem Pharmacol. 1993;45:2417-2424.
-
(1993)
Biochem Pharmacol
, vol.45
, pp. 2417-2424
-
-
Waldmeier, P.C.1
Buchle, A.M.2
Steulet, A.F.3
-
15
-
-
0033152287
-
Investigation into the correlation between the structure of hydroxypyridinones and blood-brain barrier permeability
-
Habgood MD, Liu ZD, Dehkordi LS, Khodr HH, Abbott J, Hider RC. Investigation into the correlation between the structure of hydroxypyridinones and blood-brain barrier permeability. Biochem Pharmacol. 1999;57:1305-1310.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 1305-1310
-
-
Habgood, M.D.1
Liu, Z.D.2
Dehkordi, L.S.3
Khodr, H.H.4
Abbott, J.5
Hider, R.C.6
-
16
-
-
0030005823
-
The pharmacokinetics and blood-brain barrier permeation of the chelators 1,2 dimethly-, 1,2 diethyl-, and 1-[ethan-1′ol]-2-methyl-3-hydroxypyridin-4-one in the rat
-
Fredenburg AM, Sethi RK, Allen DD, Yokel RA. The pharmacokinetics and blood-brain barrier permeation of the chelators 1,2 dimethly-, 1,2 diethyl-, and 1-[ethan-1′ol]-2-methyl-3-hydroxypyridin-4-one in the rat. Toxicology. 1996;108:191-199.
-
(1996)
Toxicology
, vol.108
, pp. 191-199
-
-
Fredenburg, A.M.1
Sethi, R.K.2
Allen, D.D.3
Yokel, R.A.4
-
17
-
-
1642550025
-
Iron chemistry
-
Templeton DM, ed, New York, NY: Marcel Dekker;
-
Harris WR. Iron chemistry. In Templeton DM, ed. Molecular and Cellular Iron Transport. New York, NY: Marcel Dekker; 2002;1-40.
-
(2002)
Molecular and Cellular Iron Transport
, pp. 1-40
-
-
Harris, W.R.1
-
18
-
-
0033532183
-
Calcein as a fluorescent probe for ferric iron. Application to iron nutrition in plant cells
-
Thomas F, Serratrice G, Beguin C, et al. Calcein as a fluorescent probe for ferric iron. Application to iron nutrition in plant cells. J Biol Chem. 1999;274:13375- 13383.
-
(1999)
J Biol Chem
, vol.274
, pp. 13375-13383
-
-
Thomas, F.1
Serratrice, G.2
Beguin, C.3
-
19
-
-
0025344836
-
A direct method for quantification of non-transferrin-bound iron
-
Singh S, Hider RC, Porter JB. A direct method for quantification of non-transferrin-bound iron. Anal Biochem. 1990;186:320-323.
-
(1990)
Anal Biochem
, vol.186
, pp. 320-323
-
-
Singh, S.1
Hider, R.C.2
Porter, J.B.3
-
20
-
-
27644539382
-
Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells
-
Glickstein H, Ben El R, Shvartsman M, Cabantchik ZI. Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood. 2005;106:3242-3250.
-
(2005)
Blood
, vol.106
, pp. 3242-3250
-
-
Glickstein, H.1
Ben, E.R.2
Shvartsman, M.3
Cabantchik, Z.I.4
-
21
-
-
33750001927
-
Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
-
Glickstein H, Ben El R, Link G, et al. Action of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequences. Blood. 2006;108:3195-3203.
-
(2006)
Blood
, vol.108
, pp. 3195-3203
-
-
Glickstein, H.1
Ben, E.R.2
Link, G.3
-
22
-
-
0037083893
-
Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor
-
Petrat F, Weisheit D, Lensen M, de Groot H, Sustmann R, Rauen U. Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor. Biochem J. 2002;362:137-147.
-
(2002)
Biochem J
, vol.362
, pp. 137-147
-
-
Petrat, F.1
Weisheit, D.2
Lensen, M.3
de Groot, H.4
Sustmann, R.5
Rauen, U.6
-
23
-
-
35048833703
-
Non-transferrin-bound iron reaches mitochondria by a chelator-inaccessible mechanism: Biological and clinical implications
-
Shvartsman M, Kikkeri R, Shanzer A, Cabantchik IZ. Non-transferrin-bound iron reaches mitochondria by a chelator-inaccessible mechanism: biological and clinical implications. Am J Physiol Cell Physiol. 2007;293:C1383-C1394.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Shvartsman, M.1
Kikkeri, R.2
Shanzer, A.3
Cabantchik, I.Z.4
-
25
-
-
0035282222
-
Spectral and metal binding properties of three single-point tryptophan mutants of the human transferring N-lobe
-
He QY, Mason AB, Lyons BA, et al. Spectral and metal binding properties of three single-point tryptophan mutants of the human transferring N-lobe. Biochem J. 2001;354:423-429.
-
(2001)
Biochem J
, vol.354
, pp. 423-429
-
-
He, Q.Y.1
Mason, A.B.2
Lyons, B.A.3
-
26
-
-
0023719131
-
Hexamethylene bis-acetamide-induced differentiation of transformed cells: Molecular and cellular effects and therapeutic application
-
Marks PA, Rifkind RA. Hexamethylene bis-acetamide-induced differentiation of transformed cells: molecular and cellular effects and therapeutic application. Int J Cell Cloning. 1988;6:230-240.
-
(1988)
Int J Cell Cloning
, vol.6
, pp. 230-240
-
-
Marks, P.A.1
Rifkind, R.A.2
-
27
-
-
34047207831
-
Iron deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21(WAF1/CIP1)
-
Alcantara O, Boldt DH. Iron deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21(WAF1/CIP1). Br J Haematol. 2007;137:252-261.
-
(2007)
Br J Haematol
, vol.137
, pp. 252-261
-
-
Alcantara, O.1
Boldt, D.H.2
-
28
-
-
0023200069
-
Plasma iron and transferrin iron-binding capacity evaluated by colorimetric and immunoprecipitation methods
-
Huebers HA, Eng MJ, Josephson BM, et al. Plasma iron and transferrin iron-binding capacity evaluated by colorimetric and immunoprecipitation methods. Clin Chem. 1987;33:273-277.
-
(1987)
Clin Chem
, vol.33
, pp. 273-277
-
-
Huebers, H.A.1
Eng, M.J.2
Josephson, B.M.3
-
29
-
-
0030739637
-
Transport of iron in the blood-brain-cerebrospinal fluid system
-
Bradbury MW. Transport of iron in the blood-brain-cerebrospinal fluid system. J Neurochem. 1997;69:443-454.
-
(1997)
J Neurochem
, vol.69
, pp. 443-454
-
-
Bradbury, M.W.1
-
30
-
-
0032533743
-
Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid
-
Moos T, Morgan EH. Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid. J Neurosci Res. 1998;54:486-494.
-
(1998)
J Neurosci Res
, vol.54
, pp. 486-494
-
-
Moos, T.1
Morgan, E.H.2
-
31
-
-
33646577477
-
Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
-
Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G. Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood. 2006;107:4142-4148.
-
(2006)
Blood
, vol.107
, pp. 4142-4148
-
-
Theurl, I.1
Mattle, V.2
Seifert, M.3
Mariani, M.4
Marth, C.5
Weiss, G.6
-
32
-
-
0028897880
-
New concepts of iron and aluminium chelation therapy with oral L1 (deferiprone) and other chelators
-
Kontoghiorghes GJ. New concepts of iron and aluminium chelation therapy with oral L1 (deferiprone) and other chelators. Analyst. 1995;120:845-851.
-
(1995)
Analyst
, vol.120
, pp. 845-851
-
-
Kontoghiorghes, G.J.1
-
33
-
-
33750716051
-
Iron: A new target for pharmacological intervention in neurodegenerative diseases
-
Whitnall M, Richardson DR. Iron: a new target for pharmacological intervention in neurodegenerative diseases. Semin Pediatr Neurol. 2006;13:186-197.
-
(2006)
Semin Pediatr Neurol
, vol.13
, pp. 186-197
-
-
Whitnall, M.1
Richardson, D.R.2
-
34
-
-
34247564692
-
Role of iron in neurodegenerative disorders
-
Berg D, Youdim MB. Role of iron in neurodegenerative disorders. Top Magn Reson Imaging. 2006;17:5-17.
-
(2006)
Top Magn Reson Imaging
, vol.17
, pp. 5-17
-
-
Berg, D.1
Youdim, M.B.2
-
36
-
-
18344410299
-
Chelation and mobilization of cellular iron by different classes of chelators
-
Zanninelli G, Glickstein H, Breuer W, et al. Chelation and mobilization of cellular iron by different classes of chelators. Mol Pharmacol. 1997;51:842-852.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 842-852
-
-
Zanninelli, G.1
Glickstein, H.2
Breuer, W.3
-
37
-
-
0034928342
-
Exploring the "iron shuttle" hypothesis in chelation therapy: Effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture
-
Link G, Konijn AM, Breuer W, Cabantchik ZI, Hershko C. Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture. J Lab Clin Med. 2001;138:130-138.
-
(2001)
J Lab Clin Med
, vol.138
, pp. 130-138
-
-
Link, G.1
Konijn, A.M.2
Breuer, W.3
Cabantchik, Z.I.4
Hershko, C.5
-
38
-
-
39049114182
-
-
Breuer W, Shvartsman M, Cabantchik ZI. Intracellular labile iron. Int J Biochem Cell Biol. Prepublished on March 19, 2007, as DOI 10.1016/j.biocel.2007. 03.010.
-
Breuer W, Shvartsman M, Cabantchik ZI. Intracellular labile iron. Int J Biochem Cell Biol. Prepublished on March 19, 2007, as DOI 10.1016/j.biocel.2007. 03.010.
-
-
-
-
39
-
-
0344154421
-
Labile iron pool: The main determinant of cellular response to oxidative stress
-
Kruszewski M. Labile iron pool: The main determinant of cellular response to oxidative stress. Mutat Res. 2003;29:81-92.
-
(2003)
Mutat Res
, vol.29
, pp. 81-92
-
-
Kruszewski, M.1
-
40
-
-
0036570964
-
A review of fluorescence methods for assessing labile iron in cells and biological fluids
-
Espósito BP, Epsztejn S, Breuer W, Cabantchik ZI. A review of fluorescence methods for assessing labile iron in cells and biological fluids. Anal Biochem. 2002;304:1-18.
-
(2002)
Anal Biochem
, vol.304
, pp. 1-18
-
-
Espósito, B.P.1
Epsztejn, S.2
Breuer, W.3
Cabantchik, Z.I.4
-
41
-
-
0018850440
-
Iron transport and storage proteins
-
Aisen P, Listowsky I. Iron transport and storage proteins. Annu Rev Biochem. 1980;49:357-393.
-
(1980)
Annu Rev Biochem
, vol.49
, pp. 357-393
-
-
Aisen, P.1
Listowsky, I.2
-
42
-
-
43249092172
-
-
Devanur LD, Neubert H, Hider RC. The Fenton activity of iron(III) in the presence of deferiprone. J Pharm Sci. Prepublished August 27, 2007, as DOI 10.1002/jps.21039.
-
Devanur LD, Neubert H, Hider RC. The Fenton activity of iron(III) in the presence of deferiprone. J Pharm Sci. Prepublished August 27, 2007, as DOI 10.1002/jps.21039.
-
-
-
-
43
-
-
0025765048
-
Ferric-salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat
-
Garrick LM, Gniecko K, Hoke JE, al-Nakeeb A, Ponka P, Garrick MD. Ferric-salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat. J Cell Physiol. 1991;146:460-465.
-
(1991)
J Cell Physiol
, vol.146
, pp. 460-465
-
-
Garrick, L.M.1
Gniecko, K.2
Hoke, J.E.3
al-Nakeeb, A.4
Ponka, P.5
Garrick, M.D.6
-
45
-
-
0141705304
-
Labile plasma iron in iron overload: Redox activity and susceptibility to chelation
-
Esposito BP, Breuer W, Sirankapracha P, Pootrakul P, Hershko C, Cabantchik ZI. Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood. 2003;102:2670-2677.
-
(2003)
Blood
, vol.102
, pp. 2670-2677
-
-
Esposito, B.P.1
Breuer, W.2
Sirankapracha, P.3
Pootrakul, P.4
Hershko, C.5
Cabantchik, Z.I.6
-
46
-
-
0037926880
-
Cytokine-mediated regulation of iron transport in human monocytic cells
-
Ludwiczek S, Aigner E, Theurl I, Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood. 2003;101:4148-4154.
-
(2003)
Blood
, vol.101
, pp. 4148-4154
-
-
Ludwiczek, S.1
Aigner, E.2
Theurl, I.3
Weiss, G.4
-
47
-
-
0025053867
-
Correlation of iron exchange between the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4- one(L1) and transferrin and possible antianaemic effects of L1 in rheumatoid arthritis
-
Vreugdenhil G, Swaak AJ, de Jeu-Jaspers C, van Eijk HG. Correlation of iron exchange between the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4- one(L1) and transferrin and possible antianaemic effects of L1 in rheumatoid arthritis. Ann Rheum Dis. 1990;49:956-957.
-
(1990)
Ann Rheum Dis
, vol.49
, pp. 956-957
-
-
Vreugdenhil, G.1
Swaak, A.J.2
de Jeu-Jaspers, C.3
van Eijk, H.G.4
-
48
-
-
0036728509
-
Iron and the anemia of chronic disease
-
Spivak JL. Iron and the anemia of chronic disease. Oncology (Williston Park). 2002;16:Suppl 10:25-33.
-
(2002)
Oncology (Williston Park)
, vol.16
, Issue.SUPPL. 10
, pp. 25-33
-
-
Spivak, J.L.1
-
49
-
-
0024311169
-
Efficacy and safety of oral iron chelator L1 in anaemic rheumatoid arthritis patients [letter]
-
Vreugdenhil G, Swaak AJ, Kontoghiorghes GJ, van Eijk HG. Efficacy and safety of oral iron chelator L1 in anaemic rheumatoid arthritis patients [letter]. Lancet. 1989;2:1398-1399.
-
(1989)
Lancet
, vol.2
, pp. 1398-1399
-
-
Vreugdenhil, G.1
Swaak, A.J.2
Kontoghiorghes, G.J.3
van Eijk, H.G.4
|