mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Cell Reports

Volumn 19, Issue 6, 2017, Pages 1083-1090

  Park, Yeonwoo ^a   Reyna Neyra, Andrea ^a   Philippe, Lucas ^a   Thoreen, Carson C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amino acid uptake; ATF4; mTOR; mTORC1

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSFER RNA LIGASE; AMINO ACID TRANSPORTER; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4E BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; ATF4 PROTEIN, HUMAN; INITIATION FACTOR 2;

5' UNTRANSLATED REGION; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ARTICLE; CONTROLLED STUDY; GENE REPRESSION; HUMAN; HUMAN CELL; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA STABILITY; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; ANIMAL; GENETICS; HEK293 CELL LINE; METABOLISM; MOUSE; RNA PROCESSING;

5' UNTRANSLATED REGIONS; ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSPORT SYSTEMS; ANIMALS; EUKARYOTIC INITIATION FACTOR-2; HEK293 CELLS; HUMANS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICE; OPEN READING FRAMES; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; RNA, MESSENGER;

EID: 85019220026     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.04.042     Document Type: Article

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