Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation

Cell Metabolism

Volumn 25, Issue 5, 2017, Pages 1160-1175.e11

  Zeng, Chun ^a   Mulas, Francesca ^a   Sui, Yinghui ^a   Guan, Tiffany ^a   Miller, Nathanael ^b,c   Tan, Yuliang ^d   Liu, Fenfen ^a   Jin, Wen ^a   Carrano, Andrea C ^a   Huising, Mark O ^e   Shirihai, Orian S ^b,c   Yeo, Gene W ^f   Sander, Maike ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amino acid metabolism; beta cell; catalase; mitochondrial; oxidative phosphorylation; proliferation; reactive oxygen species; single cell RNA seq; Srf; transcription factor

Indexed keywords

DEXTRO AMINO ACID; PROTEIN FOS; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JUN; TRANSCRIPTION FACTOR SRF; TRANSCRIPTOME; UNCLASSIFIED DRUG; AMINO ACID;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HEK293T CELL LINE; HUMAN; MALE; METABOLIC REGULATION; MITOCHONDRION; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUTRIENT; PANCREAS ISLET BETA CELL; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA SEQUENCE; SINGLE CELL ANALYSIS; TRANSCRIPTOMICS; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; METABOLISM;

AMINO ACIDS; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HUMANS; INSULIN-SECRETING CELLS; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE, INBRED C57BL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; TRANSCRIPTOME;

EID: 85019003373     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.04.014     Document Type: Article

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