Importin β1 targeting by hepatitis C virus NS3/4A protein restricts IRF3 and NF-κB signaling of IFNB1 antiviral response

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Volumn 18, Issue 6, 2017, Pages 362-377

  Gagné, Bridget ^a,b   Tremblay, Nicolas ^a,b   Park, Alex Y ^a,b   Baril, Martin ^a   Lamarre, Daniel ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

HCV; importin ; importin ; IMP 1 KPNB1; innate antiviral immunity; interferon ; IRF3; microscopy based high content screening; NF B p65; NPC; NS3 4A protein; nuclear pore complex; nuclear translocation; nucleocytoplasmic transport; RNAi screen; SeV; virus host interaction

Indexed keywords

BETA1 INTERFERON; DICER; ELONGATION FACTOR 1ALPHA; HEPACIVIRIN; IMPORTIN BETA1; INTERFERON REGULATORY FACTOR 3; KARYOPHERIN BETA; MESSENGER RNA; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; VIRAL PROTEIN; ANTIVIRUS AGENT; CARRIER PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KARYOPHERIN; KPNB1 PROTEIN, HUMAN; NS3 PROTEIN, HEPATITIS C VIRUS; NS4A COFACTOR PEPTIDE, HEPATITIS C VIRUS; PROTEINASE INHIBITOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

A-549 CELL LINE; APOPTOSIS; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE RESPONSE; GENE SILENCING; HEK293T CELL LINE; HELA CELL LINE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INNATE IMMUNITY; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN TARGETING; SENDAI VIRUS; SENDAI VIRUS INFECTION; SIGNAL TRANSDUCTION; VIRUS CELL INTERACTION; VIRUS REPLICATION; HEPACIVIRUS; IMMUNOLOGY; METABOLISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIVIRAL AGENTS; BETA KARYOPHERINS; CARRIER PROTEINS; HEPACIVIRUS; HUMANS; INTERFERON REGULATORY FACTOR-3; KARYOPHERINS; NF-KAPPA B; PROTEASE INHIBITORS; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 85018979408     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/tra.12480     Document Type: Article

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