메뉴 건너뛰기




Volumn 232, Issue 12, 2017, Pages 3251-3260

Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; TUMOR MARKER;

EID: 85018699233     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.25739     Document Type: Review
Times cited : (136)

References (134)
  • 3
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • Akers JC, Gonda D, Kim R, Carter BS, Chen CC. 2013a. Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol 113:1–11.
    • (2013) J Neurooncol , vol.113 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3    Carter, B.S.4    Chen, C.C.5
  • 5
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A, Rak J. 2008. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 10:619–624.
    • (2008) Nat Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4    May, L.5    Guha, A.6    Rak, J.7
  • 6
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. 2011. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29:341–345.
    • (2011) Nat Biotechnol , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 8
    • 84892607130 scopus 로고    scopus 로고
    • Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion
    • Atay S, Banskota S, Crow J, Sethi G, Rink L, Godwin AK. 2014. Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion. Proc Natl Acad Sci USA 111:711–716.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 711-716
    • Atay, S.1    Banskota, S.2    Crow, J.3    Sethi, G.4    Rink, L.5    Godwin, A.K.6
  • 13
    • 84902438436 scopus 로고    scopus 로고
    • Study of circulating microRNA-125b levels in serum exosomes in advanced melanoma
    • Carranza O, González Á. 2014. Study of circulating microRNA-125b levels in serum exosomes in advanced melanoma. Arch Pathol Lab Med 138:828.
    • (2014) Arch Pathol Lab Med , vol.138 , pp. 828
    • Carranza, O.1    González, Á.2
  • 16
    • 84896716487 scopus 로고    scopus 로고
    • Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells
    • Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR. 2014a. Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology 59:1118–1129.
    • (2014) Hepatology , vol.59 , pp. 1118-1129
    • Chen, L.1    Charrier, A.2    Zhou, Y.3    Chen, R.4    Yu, B.5    Agarwal, K.6    Tsukamoto, H.7    Lee, L.J.8    Paulaitis, M.E.9    Brigstock, D.R.10
  • 19
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
    • Cho JA, Park H, Lim EH, Lee KW. 2012. Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells. Int J Oncol 40:130–138.
    • (2012) Int J Oncol , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 23
    • 84900505110 scopus 로고    scopus 로고
    • Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells
    • Corrado C, Raimondo S, Saieva L, Flugy AM, De Leo G, Alessandro R. 2014. Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells. Cancer Lett 348:71–76.
    • (2014) Cancer Lett , vol.348 , pp. 71-76
    • Corrado, C.1    Raimondo, S.2    Saieva, L.3    Flugy, A.M.4    De Leo, G.5    Alessandro, R.6
  • 24
    • 53449094862 scopus 로고    scopus 로고
    • Stromal myofibroblasts are drivers of invasive cancer growth
    • De Wever O, Demetter P, Mareel M, Bracke M. 2008. Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 123:2229–2238.
    • (2008) Int J Cancer , vol.123 , pp. 2229-2238
    • De Wever, O.1    Demetter, P.2    Mareel, M.3    Bracke, M.4
  • 30
    • 84988649829 scopus 로고    scopus 로고
    • Circulating microRNA-192 as a diagnostic biomarker in human chronic lymphocytic leukemia
    • Fathullahzadeh S, Mirzaei H, Honardoost M, Sahebkar A, Salehi M. 2016. Circulating microRNA-192 as a diagnostic biomarker in human chronic lymphocytic leukemia. Cancer Gene Ther 23:327–332.
    • (2016) Cancer Gene Ther , vol.23 , pp. 327-332
    • Fathullahzadeh, S.1    Mirzaei, H.2    Honardoost, M.3    Sahebkar, A.4    Salehi, M.5
  • 34
    • 84870586668 scopus 로고    scopus 로고
    • The genomic and proteomic content of cancer cell-derived exosomes
    • Henderson MC, Azorsa DO. 2012. The genomic and proteomic content of cancer cell-derived exosomes. Front Oncol 2:38.
    • (2012) Front Oncol , vol.2 , pp. 38
    • Henderson, M.C.1    Azorsa, D.O.2
  • 36
    • 71549122588 scopus 로고    scopus 로고
    • Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells
    • Hong BS, Cho J-H, Kim H, Choi E-J, Rho S, Kim J, Kim JH, Choi D-S, Kim Y-K, Hwang D. 2009. Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells. BMC Genomics 10:556.
    • (2009) BMC Genomics , vol.10 , pp. 556
    • Hong, B.S.1    Cho, J.-H.2    Kim, H.3    Choi, E.-J.4    Rho, S.5    Kim, J.6    Kim, J.H.7    Choi, D.-S.8    Kim, Y.-K.9    Hwang, D.10
  • 37
    • 0036623140 scopus 로고    scopus 로고
    • Immune escape of tumors: Apoptosis resistance and tumor counterattack
    • Igney FH, Krammer PH. 2002. Immune escape of tumors: Apoptosis resistance and tumor counterattack. J Leukoc Biol 71:907–920.
    • (2002) J Leukoc Biol , vol.71 , pp. 907-920
    • Igney, F.H.1    Krammer, P.H.2
  • 38
    • 40849138014 scopus 로고    scopus 로고
    • Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
    • Ishida T, Kiwada H. 2008. Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. Int J Pharm 354:56–62.
    • (2008) Int J Pharm , vol.354 , pp. 56-62
    • Ishida, T.1    Kiwada, H.2
  • 40
    • 84899825335 scopus 로고    scopus 로고
    • A comprehensive overview of exosomes as drug delivery vehicles—Endogenous nanocarriers for targeted cancer therapy
    • Johnsen KB, Gudbergsson JM, Skov MN, Pilgaard L, Moos T, Duroux M. 2014. A comprehensive overview of exosomes as drug delivery vehicles—Endogenous nanocarriers for targeted cancer therapy. Biochim Biophys Acta 1846:75–87.
    • (2014) Biochim Biophys Acta , vol.1846 , pp. 75-87
    • Johnsen, K.B.1    Gudbergsson, J.M.2    Skov, M.N.3    Pilgaard, L.4    Moos, T.5    Duroux, M.6
  • 48
    • 84855519096 scopus 로고    scopus 로고
    • Competitive interactions of cancer cells and normal cells via secretory microRNAs
    • Kosaka N, Iguchi H, Yoshioka Y, Hagiwara K, Takeshita F, Ochiya T. 2012. Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem 287:1397–1405.
    • (2012) J Biol Chem , vol.287 , pp. 1397-1405
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Hagiwara, K.4    Takeshita, F.5    Ochiya, T.6
  • 52
    • 79960728743 scopus 로고    scopus 로고
    • Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC
    • Li Y, Zhang Y, Qiu F, Qiu Z. 2011. Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC. Electrophoresis 32:1976–1983.
    • (2011) Electrophoresis , vol.32 , pp. 1976-1983
    • Li, Y.1    Zhang, Y.2    Qiu, F.3    Qiu, Z.4
  • 54
    • 84857816893 scopus 로고    scopus 로고
    • Mining the gastric cancer secretome: Identification of GRN as a potential diagnostic marker for early gastric cancer
    • Loei H, Tan HT, Lim TK, Lim KH, So JB-Y, Yeoh KG, Chung MC. 2012. Mining the gastric cancer secretome: Identification of GRN as a potential diagnostic marker for early gastric cancer. J Proteome Res 11:1759–1772.
    • (2012) J Proteome Res , vol.11 , pp. 1759-1772
    • Loei, H.1    Tan, H.T.2    Lim, T.K.3    Lim, K.H.4    So, J.B.-Y.5    Yeoh, K.G.6    Chung, M.C.7
  • 56
    • 84878879881 scopus 로고    scopus 로고
    • Exosomes: Mediators of communication in eukaryotes
    • Lopez-Verrilli MA. 2013. Exosomes: Mediators of communication in eukaryotes. Biol Res 46:5–11.
    • (2013) Biol Res , vol.46 , pp. 5-11
    • Lopez-Verrilli, M.A.1
  • 58
    • 84924874243 scopus 로고    scopus 로고
    • Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity
    • Madhavan B, Yue S, Galli U, Rana S, Gross W, Müller M, Giese NA, Kalthoff H, Becker T, Büchler MW. 2015. Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity. Int J Cancer 136:2616–2627.
    • (2015) Int J Cancer , vol.136 , pp. 2616-2627
    • Madhavan, B.1    Yue, S.2    Galli, U.3    Rana, S.4    Gross, W.5    Müller, M.6    Giese, N.A.7    Kalthoff, H.8    Becker, T.9    Büchler, M.W.10
  • 63
    • 84995451048 scopus 로고    scopus 로고
    • Zinc oxide nanoparticles: Biological synthesis and biomedical applications
    • Mirzaei H, Darroudi M. 2017. Zinc oxide nanoparticles: Biological synthesis and biomedical applications. Ceram Int 43:907–914.
    • (2017) Ceram Int , vol.43 , pp. 907-914
    • Mirzaei, H.1    Darroudi, M.2
  • 65
    • 84995655551 scopus 로고    scopus 로고
    • Can curcumin and its analogs be a new treatment option in cancer therapy
    • Mirzaei H, Khoi M, Azizi M, Goodarzi M. 2016b. Can curcumin and its analogs be a new treatment option in cancer therapy? Cancer Gene Ther 23:410.
    • (2016) Cancer Gene Ther , vol.23 , pp. 410
    • Mirzaei, H.1    Khoi, M.2    Azizi, M.3    Goodarzi, M.4
  • 73
    • 84991037520 scopus 로고    scopus 로고
    • Circulating microRNA: A new candidate for diagnostic biomarker in neuroblastoma
    • Mohammadi M, Goodarzi M, Jaafari M, Mirzaei H, Mirzaei H. 2016a. Circulating microRNA: A new candidate for diagnostic biomarker in neuroblastoma. Cancer Gene Ther 23:371–372.
    • (2016) Cancer Gene Ther , vol.23 , pp. 371-372
    • Mohammadi, M.1    Goodarzi, M.2    Jaafari, M.3    Mirzaei, H.4    Mirzaei, H.5
  • 74
    • 84988654396 scopus 로고    scopus 로고
    • Mesenchymal stem cell: A new horizon in cancer gene therapy
    • Mohammadi M, Jaafari M, Mirzaei H, Mirzaei H. 2016b. Mesenchymal stem cell: A new horizon in cancer gene therapy. Cancer Gene Ther 23:285–286.
    • (2016) Cancer Gene Ther , vol.23 , pp. 285-286
    • Mohammadi, M.1    Jaafari, M.2    Mirzaei, H.3    Mirzaei, H.4
  • 76
    • 84886625070 scopus 로고    scopus 로고
    • Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity
    • Munoz JL, Bliss SA, Greco SJ, Ramkissoon SH, Ligon KL, Rameshwar P. 2013. Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity. Mol Ther Nucleic Acids 2:e126.
    • (2013) Mol Ther Nucleic Acids , vol.2
    • Munoz, J.L.1    Bliss, S.A.2    Greco, S.J.3    Ramkissoon, S.H.4    Ligon, K.L.5    Rameshwar, P.6
  • 86
    • 77953142134 scopus 로고    scopus 로고
    • Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
    • Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK. 2010. Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics 9:1085–1099.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1085-1099
    • Park, J.E.1    Tan, H.S.2    Datta, A.3    Lai, R.C.4    Zhang, H.5    Meng, W.6    Lim, S.K.7    Sze, S.K.8
  • 87
  • 93
    • 62549116582 scopus 로고    scopus 로고
    • Circulating microRNA signatures of tumor-derived exosomes for early diagnosis of non-small-cell lung cancer
    • Rosell R, Wei J, Taron M. 2009. Circulating microRNA signatures of tumor-derived exosomes for early diagnosis of non-small-cell lung cancer. Clin Lung Cancer 10:8–9.
    • (2009) Clin Lung Cancer , vol.10 , pp. 8-9
    • Rosell, R.1    Wei, J.2    Taron, M.3
  • 96
    • 27644524811 scopus 로고    scopus 로고
    • Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells
    • Safaei R, Larson BJ, Cheng TC, Gibson MA, Otani S, Naerdemann W, Howell SB. 2005. Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells. Mol Cancer Ther 4:1595–1604.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1595-1604
    • Safaei, R.1    Larson, B.J.2    Cheng, T.C.3    Gibson, M.A.4    Otani, S.5    Naerdemann, W.6    Howell, S.B.7
  • 98
    • 84945407964 scopus 로고    scopus 로고
    • Proteomics characterization of exosome cargo
    • Schey KL, Luther JM, Rose KL. 2015. Proteomics characterization of exosome cargo. Methods 87:75–82.
    • (2015) Methods , vol.87 , pp. 75-82
    • Schey, K.L.1    Luther, J.M.2    Rose, K.L.3
  • 100
    • 0043092308 scopus 로고    scopus 로고
    • Expulsion of small molecules in vesicles shed by cancer cells association with gene expression and chemosensitivity profiles
    • Shedden K, Xie XT, Chandaroy P, Chang YT, Rosania GR. 2003. Expulsion of small molecules in vesicles shed by cancer cells association with gene expression and chemosensitivity profiles. Cancer Res 63:4331–4337.
    • (2003) Cancer Res , vol.63 , pp. 4331-4337
    • Shedden, K.1    Xie, X.T.2    Chandaroy, P.3    Chang, Y.T.4    Rosania, G.R.5
  • 103
    • 84992589914 scopus 로고    scopus 로고
    • Circulating miR-21 as novel biomarker in gastric cancer Diagnostic and prognostic biomarker
    • Simonian M, Mosallayi M, Mirzaei H. 2016. Circulating miR-21 as novel biomarker in gastric cancer: Diagnostic and prognostic biomarker. Cancer Res Ther.
    • (2016) Cancer Res Ther
    • Simonian, M.1    Mosallayi, M.2    Mirzaei, H.3
  • 105
    • 52049112613 scopus 로고    scopus 로고
    • Isolation and identification of potential urinary microparticle biomarkers of bladder cancer
    • Smalley DM, Sheman NE, Nelson K, Theodorescu D. 2008. Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. J Proteome Res 7:2088–2096.
    • (2008) J Proteome Res , vol.7 , pp. 2088-2096
    • Smalley, D.M.1    Sheman, N.E.2    Nelson, K.3    Theodorescu, D.4
  • 107
    • 84874959843 scopus 로고    scopus 로고
    • Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models
    • Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. 2013. Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev 65:383–390.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 383-390
    • Suetsugu, A.1    Honma, K.2    Saji, S.3    Moriwaki, H.4    Ochiya, T.5    Hoffman, R.M.6
  • 108
    • 84964240625 scopus 로고    scopus 로고
    • Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation
    • Sugimachi K, Matsumura T, Hirata H, Uchi R, Ueda M, Ueo H, Shinden Y, Iguchi T, Eguchi H, Shirabe K. 2015. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer 112:532–538.
    • (2015) Br J Cancer , vol.112 , pp. 532-538
    • Sugimachi, K.1    Matsumura, T.2    Hirata, H.3    Uchi, R.4    Ueda, M.5    Ueo, H.6    Shinden, Y.7    Iguchi, T.8    Eguchi, H.9    Shirabe, K.10
  • 109
    • 77956264919 scopus 로고    scopus 로고
    • A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    • Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu C, Barnes S, Grizzle W, Miller D, Zhang H-G. 2010. A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther 18:1606–1614.
    • (2010) Mol Ther , vol.18 , pp. 1606-1614
    • Sun, D.1    Zhuang, X.2    Xiang, X.3    Liu, Y.4    Zhang, S.5    Liu, C.6    Barnes, S.7    Grizzle, W.8    Miller, D.9    Zhang, H.-G.10
  • 111
    • 84874755851 scopus 로고    scopus 로고
    • Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma
    • Tanaka Y, Kamohara H, Kinoshita K, Kurashige J, Ishimoto T, Iwatsuki M, Watanabe M, Baba H. 2013. Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma. Cancer 119:1159–1167.
    • (2013) Cancer , vol.119 , pp. 1159-1167
    • Tanaka, Y.1    Kamohara, H.2    Kinoshita, K.3    Kurashige, J.4    Ishimoto, T.5    Iwatsuki, M.6    Watanabe, M.7    Baba, H.8
  • 112
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    • Tauro BJ, Greening DW, Mathias RA, Ji H, Mathivanan S, Scott AM, Simpson RJ. 2012. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods 56:293–304.
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1    Greening, D.W.2    Mathias, R.A.3    Ji, H.4    Mathivanan, S.5    Scott, A.M.6    Simpson, R.J.7
  • 114
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • Taylor DD, Gercel-Taylor C. 2008. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110:13–21.
    • (2008) Gynecol Oncol , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 115
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • Tian Y, Li S, Song J, Ji T, Zhu M, Anderson GJ, Wei J, Nie G. 2014. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 35:2383–2390.
    • (2014) Biomaterials , vol.35 , pp. 2383-2390
    • Tian, Y.1    Li, S.2    Song, J.3    Ji, T.4    Zhu, M.5    Anderson, G.J.6    Wei, J.7    Nie, G.8
  • 117
    • 84879419464 scopus 로고    scopus 로고
    • Leukemia cell to endothelial cell communication via exosomal miRNAs
    • Umezu T, Ohyashiki K, Kuroda M, Ohyashiki J. 2013. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 32:2747–2755.
    • (2013) Oncogene , vol.32 , pp. 2747-2755
    • Umezu, T.1    Ohyashiki, K.2    Kuroda, M.3    Ohyashiki, J.4
  • 118
    • 84919680938 scopus 로고    scopus 로고
    • Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
    • Umezu T, Tadokoro H, Azuma K, Yoshizawa S, Ohyashiki K, Ohyashiki JH. 2014. Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. Blood 124:3748–3757.
    • (2014) Blood , vol.124 , pp. 3748-3757
    • Umezu, T.1    Tadokoro, H.2    Azuma, K.3    Yoshizawa, S.4    Ohyashiki, K.5    Ohyashiki, J.H.6
  • 119
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. 2007. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654–659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 122
    • 84902176122 scopus 로고    scopus 로고
    • Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma
    • Wang H, Hou L, Li A, Duan Y, Gao H, Song X. 2014. Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. Biomed Res Int 2014.
    • (2014) Biomed Res Int , pp. 2014
    • Wang, H.1    Hou, L.2    Li, A.3    Duan, Y.4    Gao, H.5    Song, X.6
  • 123
    • 78649958307 scopus 로고    scopus 로고
    • Cancer exosomes trigger fibroblast to myofibroblast differentiation
    • Webber J, Steadman R, Mason MD, Tabi Z, Clayton A. 2010. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Res 70:9621–9630.
    • (2010) Cancer Res , vol.70 , pp. 9621-9630
    • Webber, J.1    Steadman, R.2    Mason, M.D.3    Tabi, Z.4    Clayton, A.5
  • 124
    • 84862867271 scopus 로고    scopus 로고
    • Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth
    • Xin H, Li Y, Buller B, Katakowski M, Zhang Y, Wang X, Shang X, Zhang ZG, Chopp M. 2012. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 30:1556–1564.
    • (2012) Stem Cells , vol.30 , pp. 1556-1564
    • Xin, H.1    Li, Y.2    Buller, B.3    Katakowski, M.4    Zhang, Y.5    Wang, X.6    Shang, X.7    Zhang, Z.G.8    Chopp, M.9
  • 125
    • 84925769724 scopus 로고    scopus 로고
    • Cancer nanomedicine: From targeted delivery to combination therapy
    • Xu X, Ho W, Zhang X, Bertrand N, Farokhzad O. 2015. Cancer nanomedicine: From targeted delivery to combination therapy. Trends Mol Med 21:223–232.
    • (2015) Trends Mol Med , vol.21 , pp. 223-232
    • Xu, X.1    Ho, W.2    Zhang, X.3    Bertrand, N.4    Farokhzad, O.5
  • 126
    • 84855573739 scopus 로고    scopus 로고
    • The roles of tumor-derived exosomes in cancer pathogenesis
    • Yang C, Robbins PD. 2011. The roles of tumor-derived exosomes in cancer pathogenesis. Clin Dev Immunol 2011:842849.
    • (2011) Clin Dev Immunol , vol.2011 , pp. 842849
    • Yang, C.1    Robbins, P.D.2
  • 127
    • 84906212452 scopus 로고    scopus 로고
    • Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma
    • Ye S-b, Li Z-L, Luo D-h, Huang B-j, Chen Y-S, Zhang X-s, Cui J, Zeng Y-x, Li J. 2014. Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget 5:5439–5452.
    • (2014) Oncotarget , vol.5 , pp. 5439-5452
    • Ye, S.-B.1    Li, Z.-L.2    Luo, D.-H.3    Huang, B.-J.4    Chen, Y.-S.5    Zhang, X.-S.6    Cui, J.7    Zeng, Y.-X.8    Li, J.9
  • 128
    • 84903703152 scopus 로고    scopus 로고
    • The involvement of miR-23a/APAF1 regulation axis in colorectal cancer
    • Yong FL, Wang CW, Roslani AC, Law CW. 2014. The involvement of miR-23a/APAF1 regulation axis in colorectal cancer. Int J Mol Sci 15:11713–11729.
    • (2014) Int J Mol Sci , vol.15 , pp. 11713-11729
    • Yong, F.L.1    Wang, C.W.2    Roslani, A.C.3    Law, C.W.4
  • 133
    • 84919414483 scopus 로고    scopus 로고
    • The role of exosomes and “exosomal shuttle microRNA” in tumorigenesis and drug resistance
    • Zhao L, Liu W, Xiao J, Cao B. 2015. The role of exosomes and “exosomal shuttle microRNA” in tumorigenesis and drug resistance. Cancer Lett 356:339–346.
    • (2015) Cancer Lett , vol.356 , pp. 339-346
    • Zhao, L.1    Liu, W.2    Xiao, J.3    Cao, B.4
  • 134
    • 80053574021 scopus 로고    scopus 로고
    • Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
    • Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, Ju S, Mu J, Zhang L, Steinman L. 2011. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther 19:1769–1779.
    • (2011) Mol Ther , vol.19 , pp. 1769-1779
    • Zhuang, X.1    Xiang, X.2    Grizzle, W.3    Sun, D.4    Zhang, S.5    Axtell, R.C.6    Ju, S.7    Mu, J.8    Zhang, L.9    Steinman, L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.