Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 26, 2006, Pages 9903-9907

  Chen, Kevin G ^a   Valencia, Julio C ^a   Lai, Barry ^b   Zhang, Guofeng ^c   Paterson, Jill K ^a   Rouzaud, Francois ^a   Berens, Werner ^a   Wincovitch, Stephen M ^a   Garfield, Susan H ^a   Leapman, Richard D ^c   Hearing, Vincent J ^a   Gottesman, Michael M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cancer; Melanosomes skin; Multidrug resistance; Tumor therapy

Indexed keywords

CISPLATIN; CYTOTOXIC AGENT;

ARTICLE; CELLULAR DISTRIBUTION; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOGENESIS; MELANOMA; MELANOSOME; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CISPLATIN; CYTOPLASM; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; INDOLES; MELANOMA; MELANOSOMES; SKIN NEOPLASMS;

EID: 33745615832     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600213103     Document Type: Article

References (21)

1. Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R. C., Ghafoor, A., Feuer, E. J. & Thun, M. J. (2005) CA Cancer J. Clin. 55, 10-30.
2. Atkins, M. B., Buzaid, A. C. & Houghton, A. N., Jr. (2003) in Cutaneous Melanoma, eds. Balch, C., Houghton, A., Sober, A. & Soong, S. (Quality Medical Publishing, St. Louis), 4th Ed., pp. 589-604.
3. Dudley, M. E., Wunderlich, J. R., Yang, J. C., Sherry, R. M., Topalian, S. L., Restifo, N. P., Royal, R. E., Kammula, U., White, D. E., Mavroukakis, S. A., et al. (2005) J. Clin. Oncol. 23, 2346-2357.
4. Grossman, D. & Altieri, D. C. (2001) Cancer Metastasis Rev. 20, 3-11.
5. Helmbach, H., Rossmann, E., Kern, M. A. & Schadendorf, D. (2003) Recent Res. Cancer Res. 161, 93-110.
6. Soengas, M. S. & Lowe, S. W. (2003) Oncogene 22, 3138-3151.
7. Chen, K. G. & Gottesman, M. M. (2005) in From Melanocytes to Malignant Melanoma, eds. Hearing, V. J. & Leong, S. P. L. (Humana, Totowa, NJ), pp. 593-606.
8. Hearing, V. J. (2005) J. Dermatol. Sci. 37, 3-14.
9. Kushimoto, T., Basrur, V., Valencia, J., Matsunaga, J., Vieira, W. D., Ferrans, V. J., Muller, J., Appella, E. & Hearing, V. J. (2001) Proc. Natl. Acad. Sci. USA 98, 10698-10703.
10. Shen, D. W., Goldenberg, S., Pastan, I. & Gottesman, M. M. (2000) J. Cell. Physiol. 183, 108-116.
11. Chauhan, S. S., Liang, X. J., Su, A. W., Pai-Panandiker, A., Shen, D. W., Hanover, J. A. & Gottesman, M. M. (2003) Br. J. Cancer 88, 1327-1334.
12. Liang, X. J., Shen, D. W., Chen, K. G., Wincovitch, S. M., Garfield, S. H. & Gottesman, M. M. (2005) J. Cell. Physiol. 202, 635-641.
13. Ilinski, P., Lai, B., Cai, Z., Yun, W., Legnini, D., Talarico, T., Cholewa, M., Webster, L. K., Deacon, G. B., Rainone, S., et al. (2003) Cancer Res. 63, 1776-1779.
14. Szakacs, G., Annereau, J. P., Lahabidi, S., Shankavaram, U., Arciello, A., Bussey, K. J., Reinhold, W., Guo, Y., Kruh, G. D., Reimers, M., et al. (2004) Cancer Cell 6, 129-137.
15. Chen, K. G., Szakacs, G., Annereau, J. P., Rouzaud, F., Liang, X. J., Valencia, J. C., Nagineni, C. N., Hooks, J. J., Hearing, V. J. & Gottesman, M. M. (2005) Pigm. Cell Res. 18, 102-112.
16. Svensson, S. P., Lindgren, S., Powell, W. & Green, H. (2003) Pigm. Cell Res. 16, 351-354.
17. Pak, B. J., Li, Q., Kerbel, R. S. & Ben-David, Y. (2000) Melanoma Res. 10, 499-505.
18. Chen, G., Jaffrezou, J. P., Fleming, W. H., Duran, G. E. & Sikic, B. I. (1994) Cancer Res. 54, 4980-4987.
19. Valencia, J. C., Matsui, K., Bondy, C., Zhou, J., Rasmussen, A., Cullen, K., Yu, Z. X., Moss, J. & Ferrans, V. J. (2001) J. Invest. Med. 49, 421-433.
20. Virador, V. M., Kobayashi, N., Matsunaga, J. & Hearing, V. J. (1999) Anal. Biochem. 270, 207-219.
21. Hearing, V. J. & Ekel, T. M. (1976) Biochem. J. 157, 549-557.