-
1
-
-
0032848914
-
Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action
-
Francis SH, Corbin JD. Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action. Crit Rev Clin Lab Sci 1999;36:275-328
-
(1999)
Crit Rev Clin Lab Sci
, vol.36
, pp. 275-328
-
-
Francis, S.H.1
Corbin, J.D.2
-
2
-
-
75649097760
-
The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function
-
Grandoch M, Roscioni SS, Schmidt M. The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br J Pharmacol 2010;159:265-84
-
(2010)
Br J Pharmacol
, vol.159
, pp. 265-284
-
-
Grandoch, M.1
Roscioni, S.S.2
Schmidt, M.3
-
3
-
-
79953700575
-
Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease
-
Rabe KF. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol 2011;163:53-67
-
(2011)
Br J Pharmacol
, vol.163
, pp. 53-67
-
-
Rabe, K.F.1
-
4
-
-
0036223505
-
Heterotrimeric G protein signaling: role in asthma and allergic inflammation
-
Johnson EN, Druey KM. Heterotrimeric G protein signaling: role in asthma and allergic inflammation. J Allergy Clin Immunol 2002;109:592-602
-
(2002)
J Allergy Clin Immunol
, vol.109
, pp. 592-602
-
-
Johnson, E.N.1
Druey, K.M.2
-
5
-
-
60249089353
-
ABCD of the phosphodiesterase family: interaction and differential activity in COPD
-
Halpin DM. ABCD of the phosphodiesterase family: interaction and differential activity in COPD. Int J Chron Obstruct Pulmon Dis 2008;3:543-61
-
(2008)
Int J Chron Obstruct Pulmon Dis
, vol.3
, pp. 543-561
-
-
Halpin, D.M.1
-
6
-
-
84862290893
-
Selective PDE inhibitors as novel treatments for respiratory diseases
-
Page CP, Spina D. Selective PDE inhibitors as novel treatments for respiratory diseases. Curr Opin Pharmacol 2012;12:275-86
-
(2012)
Curr Opin Pharmacol
, vol.12
, pp. 275-286
-
-
Page, C.P.1
Spina, D.2
-
8
-
-
77953105482
-
The preclinical pharmacology of roflumilast-a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
-
Hatzelmann A, Morcillo EJ, Lungarella G, et al. The preclinical pharmacology of roflumilast-a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2010;23:235-56
-
(2010)
Pulm Pharmacol Ther
, vol.23
, pp. 235-256
-
-
Hatzelmann, A.1
Morcillo, E.J.2
Lungarella, G.3
-
9
-
-
77952527921
-
PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-?Bindependent manner
-
Sousa LP, Lopes F, Silva DM, et al. PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-?Bindependent manner. J Leukoc Biol 2010;87:895-904
-
(2010)
J Leukoc Biol
, vol.87
, pp. 895-904
-
-
Sousa, L.P.1
Lopes, F.2
Silva, D.M.3
-
10
-
-
84857485173
-
Roflumilast inhibits the release of chemokines and TNF-a from human lung macrophages stimulated with lipopolysaccharide
-
Buenestado A, Grassin-Delyle S, Guitard F, et al. Roflumilast inhibits the release of chemokines and TNF-a from human lung macrophages stimulated with lipopolysaccharide. Br J Pharmacol 2012;165:1877-90
-
(2012)
Br J Pharmacol
, vol.165
, pp. 1877-1890
-
-
Buenestado, A.1
Grassin-Delyle, S.2
Guitard, F.3
-
11
-
-
0141928029
-
Chronic obstructive pulmonary disease: molecular and cellular mechanisms
-
Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003;22:672-88
-
(2003)
Eur Respir J
, vol.22
, pp. 672-688
-
-
Barnes, P.J.1
Shapiro, S.D.2
Pauwels, R.A.3
-
12
-
-
0029900395
-
Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects
-
Tenor H, Hatzelmann A, Church MK, et al. Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br J Pharmacol 1996;118:1727-35
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1727-1735
-
-
Tenor, H.1
Hatzelmann, A.2
Church, M.K.3
-
13
-
-
0028029674
-
Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol
-
Dent G, Giembycz MA, Evans PM, et al. Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol. J Pharmacol Exp Ther 1994;271:1167-74
-
(1994)
J Pharmacol Exp Ther
, vol.271
, pp. 1167-1174
-
-
Dent, G.1
Giembycz, M.A.2
Evans, P.M.3
-
14
-
-
4444320242
-
Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils
-
Eskandari N, Wickramasinghe T, Peachell PT. Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils. Br J Pharmacol 2004;142:1265-72
-
(2004)
Br J Pharmacol
, vol.142
, pp. 1265-1272
-
-
Eskandari, N.1
Wickramasinghe, T.2
Peachell, P.T.3
-
15
-
-
0034061874
-
Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines
-
Kung TT, Crawley Y, Luo B, et al. Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines. Br J Pharmacol 2000;130:457-63
-
(2000)
Br J Pharmacol
, vol.130
, pp. 457-463
-
-
Kung, T.T.1
Crawley, Y.2
Luo, B.3
-
16
-
-
58749107184
-
Effects of the Phosphodiesterase Type 4 Inhibitor Roflumilast on Early and Late Allergic Response and Airway Hyperresponsiveness in Aspergillus-fumigatus Sensitized Mice
-
Hoymann HG, Wollin L, Müller M, et al. Effects of the Phosphodiesterase Type 4 Inhibitor Roflumilast on Early and Late Allergic Response and Airway Hyperresponsiveness in Aspergillus-fumigatus Sensitized Mice. Pharmacology 2009;83:188-95
-
(2009)
Pharmacology
, vol.83
, pp. 188-195
-
-
Hoymann, H.G.1
Wollin, L.2
Müller, M.3
-
17
-
-
11844249945
-
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro
-
Jones NA, Boswell-Smith V, Lever R, et al. The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro. Pulm Pharmacol Ther 2005;18:93-101
-
(2005)
Pulm Pharmacol Ther
, vol.18
, pp. 93-101
-
-
Jones, N.A.1
Boswell-Smith, V.2
Lever, R.3
-
18
-
-
35348853161
-
Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability
-
Sanz MJ, Cortijo J, Taha MA, et al. Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability. Br J Pharmacol 2007;152:481-92
-
(2007)
Br J Pharmacol
, vol.152
, pp. 481-492
-
-
Sanz, M.J.1
Cortijo, J.2
Taha, M.A.3
-
19
-
-
85017386748
-
Roflumilast N-oxide in Combination with Formoterol Enhances the Anti-inflammatory Effect of Dexamethasone in ASM Cells
-
Patel BS, Rahman MM, Baehring G, et al. Roflumilast N-oxide in Combination with Formoterol Enhances the Anti-inflammatory Effect of Dexamethasone in ASM Cells. Am J Respir Cell Mol Biol 2017;56:532-8
-
(2017)
Am J Respir Cell Mol Biol
, vol.56
, pp. 532-538
-
-
Patel, B.S.1
Rahman, M.M.2
Baehring, G.3
-
20
-
-
84929466885
-
Inhibitors of Phosphodiesterase 4, but Not Phosphodiesterase 3, Increase ß2-Agonist-Induced Expression of Antiinflammatory Mitogen-Activated Protein Kinase Phosphatase 1 in Airway Smooth Muscle Cells
-
Patel BS, Prabhala P, Oliver BG, et al. Inhibitors of Phosphodiesterase 4, but Not Phosphodiesterase 3, Increase ß2-Agonist-Induced Expression of Antiinflammatory Mitogen-Activated Protein Kinase Phosphatase 1 in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol 2015; 52:634-40
-
(2015)
Am J Respir Cell Mol Biol
, vol.52
, pp. 634-640
-
-
Patel, B.S.1
Prabhala, P.2
Oliver, B.G.3
-
21
-
-
67049095847
-
PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-ß1-stimulated fibroblasts
-
Togo S, Liu X, Wang X, et al. PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-ß1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol 2009;296:L959-69
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.296
, pp. L959-L969
-
-
Togo, S.1
Liu, X.2
Wang, X.3
-
22
-
-
0036014828
-
PDE4 Inhibitors Attenuate Fibroblast Chemotaxis and Contraction of Native Collagen Gels
-
Kohyama T, Liu X, Wen F-Q, et al. PDE4 Inhibitors Attenuate Fibroblast Chemotaxis and Contraction of Native Collagen Gels. Am J Respir Cell Mol Biol 2002;26:694-701
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 694-701
-
-
Kohyama, T.1
Liu, X.2
Wen, F.-Q.3
-
23
-
-
65449171997
-
Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycininduced lung injury
-
Cortijo J, Iranzo A, Milara X, et al. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycininduced lung injury. Br J Pharmacol 2009;156:534-44
-
(2009)
Br J Pharmacol
, vol.156
, pp. 534-544
-
-
Cortijo, J.1
Iranzo, A.2
Milara, X.3
-
24
-
-
77951793917
-
Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice
-
Udalov S, Dumitrascu R, Pullamsetti SS, et al. Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice. BMC Pulm Med 2010;10:26
-
(2010)
BMC Pulm Med
, vol.10
, pp. 26
-
-
Udalov, S.1
Dumitrascu, R.2
Pullamsetti, S.S.3
-
25
-
-
0035084103
-
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro
-
Hatzelmann A, Schudt C. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther 2001;297:267-79
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 267-279
-
-
Hatzelmann, A.1
Schudt, C.2
-
26
-
-
9844225600
-
Inflammatory cells in the bronchial glands of smokers with chronic bronchitis
-
Saetta M, Turato G, Facchini FM, et al. Inflammatory cells in the bronchial glands of smokers with chronic bronchitis. Am J Respir Crit Care Med 1997;156:1633-9
-
(1997)
Am J Respir Crit Care Med
, vol.156
, pp. 1633-1639
-
-
Saetta, M.1
Turato, G.2
Facchini, F.M.3
-
27
-
-
0035131224
-
Relationship of epidermal growth factor receptors to goblet cell production in human bronchi
-
Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 2001;163:511-6
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 511-516
-
-
Takeyama, K.1
Fahy, J.V.2
Nadel, J.A.3
-
28
-
-
13544273183
-
Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
-
Mata M, Sarria B, Buenestado A, et al. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax 2005;60:144-52
-
(2005)
Thorax
, vol.60
, pp. 144-152
-
-
Mata, M.1
Sarria, B.2
Buenestado, A.3
-
29
-
-
84864422831
-
Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro
-
Milara J, Armengot M, Banuls P, et al. Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro. Br J Pharmacol 2012;166:2243-62
-
(2012)
Br J Pharmacol
, vol.166
, pp. 2243-2262
-
-
Milara, J.1
Armengot, M.2
Banuls, P.3
-
30
-
-
22944440063
-
Dynamic Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Type 3 and Type 4D Phosphodiesterase Inhibitors
-
Liu S, Veilleux A, Zhang L, et al. Dynamic Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Type 3 and Type 4D Phosphodiesterase Inhibitors. J Pharmacol Exp Ther 2005;314:846-54
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 846-854
-
-
Liu, S.1
Veilleux, A.2
Zhang, L.3
-
31
-
-
84858276693
-
Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells
-
Tannheimer SL, Sorensen EA, Haran AC, et al. Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells. Pulm Pharmacol Ther 2012;25:178-84
-
(2012)
Pulm Pharmacol Ther
, vol.25
, pp. 178-184
-
-
Tannheimer, S.L.1
Sorensen, E.A.2
Haran, A.C.3
-
32
-
-
84884171273
-
Roflumilast Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-a and Chemokine Production by Human Lung Parenchyma
-
Buenestado A, Chaumais M-C, Grassin-Delyle S, et al. Roflumilast Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-a and Chemokine Production by Human Lung Parenchyma. PLoS ONE 2013;8:e74640
-
(2013)
PLoS ONE
, vol.8
-
-
Buenestado, A.1
Chaumais, M.-C.2
Grassin-Delyle, S.3
-
33
-
-
84858842750
-
Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts
-
Tannheimer SL, Wright CD, Salmon M. Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts. Respir Res 2012;13:28
-
(2012)
Respir Res
, vol.13
, pp. 28
-
-
Tannheimer, S.L.1
Wright, C.D.2
Salmon, M.3
-
34
-
-
84875473420
-
Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe COPD
-
Moodley T, Wilson SM, Joshi T, et al. Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe COPD. Mol Pharmacol 2013;83:894-906
-
(2013)
Mol Pharmacol
, vol.83
, pp. 894-906
-
-
Moodley, T.1
Wilson, S.M.2
Joshi, T.3
-
35
-
-
11844267183
-
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
-
Lipworth BJ. Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet 2005;365:167-75
-
(2005)
Lancet
, vol.365
, pp. 167-175
-
-
Lipworth, B.J.1
-
36
-
-
81355154616
-
Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
-
Gauvreau GM, Boulet LP, Schmid-Wirlitsch C, et al. Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects. Respir Res 2011;12:140
-
(2011)
Respir Res
, vol.12
, pp. 140
-
-
Gauvreau, G.M.1
Boulet, L.P.2
Schmid-Wirlitsch, C.3
-
37
-
-
23244467556
-
Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions
-
van Schalkwyk E, Strydom K, Williams Z, et al. Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions. J Allergy Clin Immunol 2005;116:292-8
-
(2005)
J Allergy Clin Immunol
, vol.116
, pp. 292-298
-
-
van Schalkwyk, E.1
Strydom, K.2
Williams, Z.3
-
38
-
-
0036179542
-
The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise-Induced Asthma and Leads to Suppression of LPS-Stimulated TNF-a Ex Vivo
-
Timmer W, Leclerc V, Birraux G, et al. The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise-Induced Asthma and Leads to Suppression of LPS-Stimulated TNF-a Ex Vivo. J Clin Pharmacol 2002;42:297-303
-
(2002)
J Clin Pharmacol
, vol.42
, pp. 297-303
-
-
Timmer, W.1
Leclerc, V.2
Birraux, G.3
-
39
-
-
11844281758
-
Roflumilast a novel selective PDE4 inhibitor shows early onset of efficacy in asthma
-
(Abstr)
-
Aubier M, Sauer R, Boszormenyi G, et al. Roflumilast a novel selective PDE4 inhibitor shows early onset of efficacy in asthma. Am J Respir Crit Care Med 2004;169:A322 (Abstr)
-
(2004)
Am J Respir Crit Care Med
, vol.169
-
-
Aubier, M.1
Sauer, R.2
Boszormenyi, G.3
-
40
-
-
33644904643
-
Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma
-
Bousquet J, Aubier M, Sastre J, et al. Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma. Allergy 2006;61:72-8
-
(2006)
Allergy
, vol.61
, pp. 72-78
-
-
Bousquet, J.1
Aubier, M.2
Sastre, J.3
-
41
-
-
0242312410
-
Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor is effective in the treatment of asthma
-
Leichtl S, Schmid-Wirlitsch C, Bredenbröker D, et al. Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor is effective in the treatment of asthma. Eur Respir J 2002;20:abstr 303S
-
(2002)
Eur Respir J
, vol.20
-
-
Leichtl, S.1
Schmid-Wirlitsch, C.2
Bredenbröker, D.3
-
42
-
-
84973110915
-
Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-tosevere asthma
-
Bateman ED, Goehring U-M, Richard F, Watz H. Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-tosevere asthma. J Allergy Clin Immunol 2016;138:142-9.e8
-
(2016)
J Allergy Clin Immunol
, vol.138
-
-
Bateman, E.D.1
Goehring, U.-M.2
Richard, F.3
Watz, H.4
-
43
-
-
0242312410
-
A new orally active, selective phosphodiesterase 4 inhibitor, with beclomethasone propionate in asthma control
-
Albrecht A, Leichtl S, Bredenbröker D, et al. A new orally active, selective phosphodiesterase 4 inhibitor, with beclomethasone propionate in asthma control. Eur Respir J 2002;20:304S
-
(2002)
Eur Respir J
, vol.20
-
-
Albrecht, A.1
Leichtl, S.2
Bredenbröker, D.3
-
44
-
-
84964452549
-
Roflumilast for asthma: Efficacy findings in placebo-controlled studies
-
Meltzer EO, Chervinsky P, Busse W, et al. Roflumilast for asthma: Efficacy findings in placebo-controlled studies. Pulm Pharmacol Ther 2015;35:S20-7
-
(2015)
Pulm Pharmacol Ther
, vol.35
, pp. S20-S27
-
-
Meltzer, E.O.1
Chervinsky, P.2
Busse, W.3
-
45
-
-
0142012148
-
Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
-
Gamble E, Grootendorst DC, Brightling CE, et al. Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;168:976-82
-
(2003)
Am J Respir Crit Care Med
, vol.168
, pp. 976-982
-
-
Gamble, E.1
Grootendorst, D.C.2
Brightling, C.E.3
-
46
-
-
36749063803
-
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
-
Grootendorst DC, Gauw SA, Verhoosel RM, et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax 2007;62:1081-7
-
(2007)
Thorax
, vol.62
, pp. 1081-1087
-
-
Grootendorst, D.C.1
Gauw, S.A.2
Verhoosel, R.M.3
-
47
-
-
79957877219
-
-
Management, and Prevention of COPD 2014.Global Initiative for Chronic Obstructive Lung Disease (GOLD)
-
Global Strategy for Diagnosis, Management, and Prevention of COPD 2014.Global Initiative for Chronic Obstructive Lung Disease (GOLD). Available online: http://www.goldcopd.org/guidelines-global-strategy-fordiagnosis-management.html
-
Global Strategy for Diagnosis
-
-
-
48
-
-
84894774631
-
Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus placebo for chronic obstructive pulmonary disease
-
Nannini LJ, Poole P, Milan SJ, et al. Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2013;11:CD003794
-
(2013)
Cochrane Database Syst Rev
, vol.11
-
-
Nannini, L.J.1
Poole, P.2
Milan, S.J.3
-
49
-
-
0035963952
-
Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study
-
Compton CH, Gubb J, Nieman R, et al. Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study. Lancet 2001;358:265-70
-
(2001)
Lancet
, vol.358
, pp. 265-270
-
-
Compton, C.H.1
Gubb, J.2
Nieman, R.3
-
50
-
-
11844307130
-
Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease
-
Bredenbröker D, Syed J, Leichtl S, et al. Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease. Eur Respir J 2002;20:abstr 374S
-
(2002)
Eur Respir J
, vol.20
-
-
Bredenbröker, D.1
Syed, J.2
Leichtl, S.3
-
51
-
-
23744451716
-
Roflumilast-an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
-
Rabe KF, Bateman ED, O'Donnell D, et al. Roflumilast-an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2005;366:563-71
-
(2005)
Lancet
, vol.366
, pp. 563-571
-
-
Rabe, K.F.1
Bateman, E.D.2
O'Donnell, D.3
-
52
-
-
69149103642
-
Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
-
Calverley PM, Rabe KF, Goehring UM, et al. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet 2009;374:685-94
-
(2009)
Lancet
, vol.374
, pp. 685-694
-
-
Calverley, P.M.1
Rabe, K.F.2
Goehring, U.M.3
-
53
-
-
34447310046
-
Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease
-
Calverley PM, Sanchez-Toril F, McIvor A, et al. Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;176:154-61
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 154-161
-
-
Calverley, P.M.1
Sanchez-Toril, F.2
McIvor, A.3
-
54
-
-
79251588730
-
Reduction of exacerbations by the PDE4 inhibitor roflumilast-the importance of defining different subsets of patients with COPD
-
Rennard SI, Calverley PM, Goehring UM, et al. Reduction of exacerbations by the PDE4 inhibitor roflumilast-the importance of defining different subsets of patients with COPD. Respir Res 2011;12:18
-
(2011)
Respir Res
, vol.12
, pp. 18
-
-
Rennard, S.I.1
Calverley, P.M.2
Goehring, U.M.3
-
55
-
-
79851471591
-
Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD
-
Giembycz MA, Field SK. Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD. Drug Des Devel Ther 2010;4:147-58
-
(2010)
Drug Des Devel Ther
, vol.4
, pp. 147-158
-
-
Giembycz, M.A.1
Field, S.K.2
-
56
-
-
84877589288
-
Efficacy of roflumilast in the chronic obstructive pulmonary disease frequent exacerbator phenotype
-
Wedzicha JA, Rabe KF, Martinez FJ, et al. Efficacy of roflumilast in the chronic obstructive pulmonary disease frequent exacerbator phenotype. Chest 2013;143:1302-11
-
(2013)
Chest
, vol.143
, pp. 1302-1311
-
-
Wedzicha, J.A.1
Rabe, K.F.2
Martinez, F.J.3
-
57
-
-
84871698675
-
Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy?. The REACT study protocol
-
Calverley PM, Martinez FJ, Fabbri LM, et al. Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? The REACT study protocol. Int J Chron Obstruct Pulmon Dis 2012;7:375-82
-
(2012)
Int J Chron Obstruct Pulmon Dis
, vol.7
, pp. 375-382
-
-
Calverley, P.M.1
Martinez, F.J.2
Fabbri, L.M.3
-
58
-
-
84924250308
-
Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial
-
Martinez FJ, Calverley PM, Goehring UM, et al. Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet 2015;385:857-66
-
(2015)
Lancet
, vol.385
, pp. 857-866
-
-
Martinez, F.J.1
Calverley, P.M.2
Goehring, U.M.3
-
59
-
-
84988882477
-
Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting beta2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial
-
Martinez FJ, Rabe KF, Sethi S, et al. Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting beta2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial. Am J Respir Crit Care Med 2016;194:559-67
-
(2016)
Am J Respir Crit Care Med
, vol.194
, pp. 559-567
-
-
Martinez, F.J.1
Rabe, K.F.2
Sethi, S.3
-
60
-
-
69149098943
-
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
-
Fabbri LM, Calverley PM, Izquierdo-Alonso JL, et al. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet 2009;374:695-703
-
(2009)
Lancet
, vol.374
, pp. 695-703
-
-
Fabbri, L.M.1
Calverley, P.M.2
Izquierdo-Alonso, J.L.3
-
61
-
-
84892664131
-
Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study
-
Zheng J, Yang J, Zhou X, et al. Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study. Chest 2014;145:44-52
-
(2014)
Chest
, vol.145
, pp. 44-52
-
-
Zheng, J.1
Yang, J.2
Zhou, X.3
-
62
-
-
84957411236
-
Interventions for bronchiectasis: an overview of Cochrane systematic reviews
-
Welsh EJ, Evans DJ, Fowler SJ, et al. Interventions for bronchiectasis: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 2015: CD010337
-
(2015)
Cochrane Database Syst Rev
-
-
Welsh, E.J.1
Evans, D.J.2
Fowler, S.J.3
-
63
-
-
85067220125
-
Bronchiectasis in the Last Five Years: New Developments
-
Khoo JK, Venning V, Wong C, et al. Bronchiectasis in the Last Five Years: New Developments. J Clin Med 2016;5:115
-
(2016)
J Clin Med
, vol.5
, pp. 115
-
-
Khoo, J.K.1
Venning, V.2
Wong, C.3
-
64
-
-
85060427010
-
Effect Of Roflumilast(Daxas®) In Patients With Symptomatic Non-Cystic Fibrosis Bronchiectasis
-
Park J. Effect Of Roflumilast(Daxas®) In Patients With Symptomatic Non-Cystic Fibrosis Bronchiectasis. Am J Respir Crit Care Med 2014;189: A625
-
(2014)
Am J Respir Crit Care Med
, vol.189
-
-
Park, J.1
-
65
-
-
79551603829
-
Characterisation of COPD heterogeneity in the ECLIPSE cohort
-
Agusti A, Calverley PM, Celli B, et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res 2010;11:122
-
(2010)
Respir Res
, vol.11
, pp. 122
-
-
Agusti, A.1
Calverley, P.M.2
Celli, B.3
-
66
-
-
81055130028
-
Factors Associated With Bronchiectasis in Patients With COPD
-
Martínez-García Má, Soler-Cataluña JJ, Donat Sanz Y, et al. Factors Associated With Bronchiectasis in Patients With COPD. Chest 2011;140:1130-7
-
(2011)
Chest
, vol.140
, pp. 1130-1137
-
-
Martínez-García, Má.1
Soler-Cataluña, J.J.2
Donat Sanz, Y.3
-
67
-
-
84876869179
-
Prognostic Value of Bronchiectasis in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease
-
Martínez-García MA, de la Rosa Carrillo D, Soler-Cataluña JJ, et al. Prognostic Value of Bronchiectasis in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2013;187:823-31
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 823-831
-
-
Martínez-García, M.A.1
de la Rosa Carrillo, D.2
Soler-Cataluña, J.J.3
-
68
-
-
79959272070
-
Cough and sputum production as risk factors for poor outcomes in patients with COPD
-
Miravitlles M. Cough and sputum production as risk factors for poor outcomes in patients with COPD. Respir Med 2011;105:1118-28
-
(2011)
Respir Med
, vol.105
, pp. 1118-1128
-
-
Miravitlles, M.1
-
69
-
-
64749104557
-
Cough and Sputum Production Are Associated With Frequent Exacerbations and Hospitalizations in COPD Subjects
-
Burgel P-R, Nesme-Meyer P, Chanez P, et al. Cough and Sputum Production Are Associated With Frequent Exacerbations and Hospitalizations in COPD Subjects. Chest 2009;135:975-82
-
(2009)
Chest
, vol.135
, pp. 975-982
-
-
Burgel, P.-R.1
Nesme-Meyer, P.2
Chanez, P.3
-
70
-
-
40649087414
-
Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms
-
Fuschillo S, De Felice A, Balzano G. Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms. Eur Respir J 2008;31:396-406
-
(2008)
Eur Respir J
, vol.31
, pp. 396-406
-
-
Fuschillo, S.1
De Felice, A.2
Balzano, G.3
-
71
-
-
84990960707
-
Inflammatory mechanisms in patients with chronic obstructive pulmonary disease
-
Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2016;138:16-27
-
(2016)
J Allergy Clin Immunol
, vol.138
, pp. 16-27
-
-
Barnes, P.J.1
-
72
-
-
33845510331
-
Neutrophilic inflammation: "Don't you go to pieces on me!"
-
Stockley RA. Neutrophilic inflammation: "Don't you go to pieces on me!" Eur Respir J 2006;28:257-8
-
(2006)
Eur Respir J
, vol.28
, pp. 257-258
-
-
Stockley, R.A.1
-
73
-
-
84872923830
-
The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly
-
Zeki AA, Schivo M, Chan A, et al. The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly. J Allergy (Cairo) 2011;2011:861926
-
(2011)
J Allergy (Cairo)
, vol.2011
-
-
Zeki, A.A.1
Schivo, M.2
Chan, A.3
-
74
-
-
84874926231
-
The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations
-
Louie S, Zeki AA, Schivo M, et al. The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations. Expert Rev Clin Pharmacol 2013;6:197-219
-
(2013)
Expert Rev Clin Pharmacol
, vol.6
, pp. 197-219
-
-
Louie, S.1
Zeki, A.A.2
Schivo, M.3
-
76
-
-
84984890217
-
Prevention of Acute Exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline
-
Criner GJ, Bourbeau J, Diekemper RL, et al. Prevention of Acute Exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest 2015;147:894-942
-
(2015)
Chest
, vol.147
, pp. 894-942
-
-
Criner, G.J.1
Bourbeau, J.2
Diekemper, R.L.3
-
77
-
-
79957877219
-
-
Management, and Prevention of COP-2016
-
Global Strategy for Diagnosis, Management, and Prevention of COP-2016. Available online: http://goldcopd.org/global-strategy-diagnosis-managementprevention-copd-2016/
-
Global Strategy for Diagnosis
-
-
-
79
-
-
0037173056
-
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
-
Ito K, Lim S, Caramori G, et al. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A 2002;99:8921-6
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8921-8926
-
-
Ito, K.1
Lim, S.2
Caramori, G.3
-
80
-
-
84990065843
-
Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial
-
Cosío BG, Shafiek H, Iglesias A, et al. Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial. Chest 2016;150:123-30
-
(2016)
Chest
, vol.150
, pp. 123-130
-
-
Cosío, B.G.1
Shafiek, H.2
Iglesias, A.3
-
81
-
-
79960170105
-
Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults
-
Böhmer G, Gleiter CH, Hunnemeyer A, et al. Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults. Int J Clin Pharmacol Ther 2011;49:451-60
-
(2011)
Int J Clin Pharmacol Ther
, vol.49
, pp. 451-460
-
-
Böhmer, G.1
Gleiter, C.H.2
Hunnemeyer, A.3
-
82
-
-
84873661428
-
Efficacy and safety of roflumilast in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
-
Oba Y, Lone NA. Efficacy and safety of roflumilast in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Ther Adv Respir Dis 2013;7:13-24
-
(2013)
Ther Adv Respir Dis
, vol.7
, pp. 13-24
-
-
Oba, Y.1
Lone, N.A.2
-
83
-
-
79958032736
-
Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis
-
Mills EJ, Druyts E, Ghement I, et al. Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis. Clin Epidemiol 2011;3:107-29
-
(2011)
Clin Epidemiol
, vol.3
, pp. 107-129
-
-
Mills, E.J.1
Druyts, E.2
Ghement, I.3
-
84
-
-
21044458874
-
Decreased histone deacetylase activity in chronic obstructive pulmonary disease
-
Ito K, Ito M, Elliott WM, et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 2005;352:1967-76
-
(2005)
N Engl J Med
, vol.352
, pp. 1967-1976
-
-
Ito, K.1
Ito, M.2
Elliott, W.M.3
-
85
-
-
0036683630
-
Expression and activity of histone deacetylases in human asthmatic airways
-
Ito K, Caramori G, Lim S, et al. Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med 2002;166:392-6
-
(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 392-396
-
-
Ito, K.1
Caramori, G.2
Lim, S.3
-
86
-
-
84905578194
-
Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease
-
Milara J, Lluch J, Almudever P, et al. Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2014;134:314-22
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 314-322
-
-
Milara, J.1
Lluch, J.2
Almudever, P.3
-
87
-
-
84866148535
-
Effect of the phosphodiesterase 4 inhibitor roflumilast on glucose metabolism in patients with treatment-naive, newly diagnosed type 2 diabetes mellitus
-
Wouters EF, Bredenbroker D, Teichmann P, et al. Effect of the phosphodiesterase 4 inhibitor roflumilast on glucose metabolism in patients with treatment-naive, newly diagnosed type 2 diabetes mellitus. J Clin Endocrinol Metab 2012;97:E1720-5
-
(2012)
J Clin Endocrinol Metab
, vol.97
-
-
Wouters, E.F.1
Bredenbroker, D.2
Teichmann, P.3
-
88
-
-
84919329574
-
Vulnerable COPD patients with comorbidities: the role of roflumilast
-
Lipari M, Kale-Pradhan PB. Vulnerable COPD patients with comorbidities: the role of roflumilast. Ther Clin Risk Manag 2014;10:969-76
-
(2014)
Ther Clin Risk Manag
, vol.10
, pp. 969-976
-
-
Lipari, M.1
Kale-Pradhan, P.B.2
-
89
-
-
84860473468
-
Physiological effects of roflumilast at rest and during exercise in COPD
-
O'Donnell DE, Bredenbröker D, Brose M, et al. Physiological effects of roflumilast at rest and during exercise in COPD. Eur Respir J 2012;39:1104-12
-
(2012)
Eur Respir J
, vol.39
, pp. 1104-1112
-
-
O'Donnell, D.E.1
Bredenbröker, D.2
Brose, M.3
-
90
-
-
84903268704
-
Roflumilast and dyspnea in patients with moderate to very severe chronic obstructive pulmonary disease: a pooled analysis of four clinical trials
-
Rennard SI, Sun SX, Tourkodimitris S, et al. Roflumilast and dyspnea in patients with moderate to very severe chronic obstructive pulmonary disease: a pooled analysis of four clinical trials. Int J Chron Obstruct Pulmon Dis 2014;9:657-73
-
(2014)
Int J Chron Obstruct Pulmon Dis
, vol.9
, pp. 657-673
-
-
Rennard, S.I.1
Sun, S.X.2
Tourkodimitris, S.3
-
91
-
-
84903273716
-
Does roflumilast improve dyspnea in patients with chronic obstructive pulmonary disease?. A meta-analysis
-
Pan L, Guo YZ, Zhang B, et al. Does roflumilast improve dyspnea in patients with chronic obstructive pulmonary disease? A meta-analysis. J Thorac Dis 2013;5:422-9
-
(2013)
J Thorac Dis
, vol.5
, pp. 422-429
-
-
Pan, L.1
Guo, Y.Z.2
Zhang, B.3
-
92
-
-
66749187721
-
A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD
-
Vestbo J, Tan L, Atkinson G, et al. A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD. Eur Respir J 2009;33:1039-44
-
(2009)
Eur Respir J
, vol.33
, pp. 1039-1044
-
-
Vestbo, J.1
Tan, L.2
Atkinson, G.3
-
93
-
-
84896142349
-
Phosphodiesterase 4 Inhibition in the Treatment of Psoriasis, Psoriatic Arthritis and Other Chronic Inflammatory Diseases
-
Wittmann M, Helliwell PS. Phosphodiesterase 4 Inhibition in the Treatment of Psoriasis, Psoriatic Arthritis and Other Chronic Inflammatory Diseases. Dermatol Ther (Heidelb) 2013;3:1-15
-
(2013)
Dermatol Ther (Heidelb)
, vol.3
, pp. 1-15
-
-
Wittmann, M.1
Helliwell, P.S.2
-
94
-
-
77249116286
-
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates antiinflammatory activity in vitro and in a model of psoriasis
-
Schafer PH, Parton A, Gandhi AK, et al. Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates antiinflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol 2010;159:842-55
-
(2010)
Br J Pharmacol
, vol.159
, pp. 842-855
-
-
Schafer, P.H.1
Parton, A.2
Gandhi, A.K.3
-
95
-
-
84925758089
-
Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer's disease: a translational overview
-
Heckman PR, Wouters C, Prickaerts J. Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer's disease: a translational overview. Curr Pharm Des 2015;21:317-31
-
(2015)
Curr Pharm Des
, vol.21
, pp. 317-331
-
-
Heckman, P.R.1
Wouters, C.2
Prickaerts, J.3
-
96
-
-
84908203966
-
Phosphodiesterase inhibition in cognitive decline
-
García-Barroso C, Ugarte A, Martinez M, et al. Phosphodiesterase inhibition in cognitive decline. J Alzheimers Dis 2014;42 Suppl 4:S561-73
-
(2014)
J Alzheimers Dis
, vol.42
, pp. S561-S573
-
-
García-Barroso, C.1
Ugarte, A.2
Martinez, M.3
-
98
-
-
84914170739
-
Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats
-
Jabaris SGSL, Sumathy H, Kumar RS, et al. Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats. Eur J Pharmacol 2015;746:138-47
-
(2015)
Eur J Pharmacol
, vol.746
, pp. 138-147
-
-
Jabaris, S.G.S.L.1
Sumathy, H.2
Kumar, R.S.3
-
99
-
-
84911944069
-
cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases
-
Martinez A, Gil C. cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opin Ther Pat 2014;24:1311-21
-
(2014)
Expert Opin Ther Pat
, vol.24
, pp. 1311-1321
-
-
Martinez, A.1
Gil, C.2
|