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Volumn 10, Issue , 2014, Pages 969-976

Vulnerable COPD patients with comorbidities: The role of rofumilast

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BISOPROLOL; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; MUSCARINIC RECEPTOR BLOCKING AGENT; PLACEBO; ROFLUMILAST; SALMETEROL; TIOTROPIUM BROMIDE;

EID: 84919329574     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S55105     Document Type: Review
Times cited : (5)

References (39)
  • 2
    • 24344473823 scopus 로고    scopus 로고
    • Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease
    • Rutten FH, Cramer MJ, Grobbee DE, et al. Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease. Eur Heart J. 2005;26(18):1887–1894.
    • (2005) Eur Heart J , vol.26 , Issue.18 , pp. 1887-1894
    • Rutten, F.H.1    Cramer, M.J.2    Grobbee, D.E.3
  • 3
    • 77954924611 scopus 로고    scopus 로고
    • ECHOS Lung Function Study Group. The prognostic importance of lung function in patients admitted with heart failure
    • Iversen KK, Kjaergaard J, Akkan D, et al; ECHOS Lung Function Study Group. The prognostic importance of lung function in patients admitted with heart failure. Eur J Heart Fail. 2010;12(7):685–691.
    • (2010) Eur J Heart Fail , vol.12 , Issue.7 , pp. 685-691
    • Iversen, K.K.1    Kjaergaard, J.2    Akkan, D.3
  • 4
    • 84885842429 scopus 로고    scopus 로고
    • 2013 ACCF/AHA guideline for
    • Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128(16): 1810–1852.
    • (2013) Circulation , vol.128 , Issue.16 , pp. 1810-1852
    • Yancy, C.W.1    Jessup, M.2    Bozkurt, B.3
  • 5
    • 84871311607 scopus 로고    scopus 로고
    • 2012 ACCF/AHA/ACP/
    • Fihn SD, Gardin JM, Abrams J, et al; American College of Cardiology Foundation; American Heart Association Task Force on Practice Guidelines; American College of Physicians, et al. 2012 ACCF/AHA/ACP/ AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2012;60(24):e44–e164.
    • (2012) J am Coll Cardiol , vol.60 , Issue.24 , pp. e44-e164
    • Fihn, S.D.1    Gardin, J.M.2    Abrams, J.3
  • 6
    • 83455240965 scopus 로고    scopus 로고
    • Adrenergic agonists and antagonists
    • In:Brunton LL, Chabner BA, Knollmann BC, editors, 12th ed. New York, NY: The McGraw-Hill Companies
    • Westfall TC, Westfall DP. Adrenergic agonists and antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. New York, NY: The McGraw-Hill Companies; 2011:277–355.
    • (2011) Goodman & Gilman’s , pp. 277-355
    • Westfall, T.C.1    Westfall, D.P.2
  • 7
    • 0036052478 scopus 로고    scopus 로고
    • Cardioselective beta-blockers for chronic obstructive pulmonary disease
    • Salpeter S, Ormiston T, Salpeter E. Cardioselective beta-blockers for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2005;(4):CD003566.
    • (2005) Cochrane Database Syst Rev , Issue.4
    • Salpeter, S.1    Ormiston, T.2    Salpeter, E.3
  • 8
    • 84862766531 scopus 로고    scopus 로고
    • Effect of bisoprolol on respiratory function and exercise capacity in chronic obstructive pulmonary disease
    • Mainguy V, Girard D, Maltais F, et al. Effect of bisoprolol on respiratory function and exercise capacity in chronic obstructive pulmonary disease. Am J Cardiol. 2012;110(2):258–263.
    • (2012) Am J Cardiol , vol.110 , Issue.2 , pp. 258-263
    • Mainguy, V.1    Girard, D.2    Maltais, F.3
  • 9
    • 84868198047 scopus 로고    scopus 로고
    • Association between β-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension
    • Stefan MS, Rothberg MB, Priya A, Pekow PS, Au DH, Lindenauer PK. Association between β-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension. Thorax. 2012;67(11):977–984.
    • (2012) Thorax , vol.67 , Issue.11 , pp. 977-984
    • Stefan, M.S.1    Rothberg, M.B.2    Priya, A.3    Pekow, P.S.4    Au, D.H.5    Lindenauer, P.K.6
  • 10
    • 73649092160 scopus 로고    scopus 로고
    • Screening, prevention and treatment of osteoporosis in patients with chronic obstructive pulmonary disease – a population-based database study
    • Madsen H, Brixen K, Hallas J. Screening, prevention and treatment of osteoporosis in patients with chronic obstructive pulmonary disease – a population-based database study. Clin Respir J. 2010;4(1):22–29.
    • (2010) Clin Respir J , vol.4 , Issue.1 , pp. 22-29
    • Madsen, H.1    Brixen, K.2    Hallas, J.3
  • 11
    • 0034727828 scopus 로고    scopus 로고
    • Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease
    • Lung Health Study Research Group. Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N Engl J Med. 2000;343(26):1902–1909.
    • (2000) N Engl J Med , vol.343 , Issue.26 , pp. 1902-1909
  • 12
    • 73149110829 scopus 로고    scopus 로고
    • Prevalence and progression of osteoporosis in patients with COPD: Results from the TOwards a Revolution in COPD Health study
    • Ferguson GT, Calverley PM, Anderson JA, et al. Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study. Chest. 2009;136(6): 1456–1465.
    • (2009) Chest , vol.136 , Issue.6 , pp. 1456-1465
    • Ferguson, G.T.1    Calverley, P.M.2    Erson, J.A.3
  • 13
    • 0345188819 scopus 로고    scopus 로고
    • Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease
    • Pauwels RA, Löfdahl CG, Laitinen LA, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med. 1999;340(25):1948–1953.
    • (1999) N Engl J Med , vol.340 , Issue.25 , pp. 1948-1953
    • Pauwels, R.A.1    Löfdahl, C.G.2    Laitinen, L.A.3
  • 14
    • 0028237807 scopus 로고
    • Corticosteroids contribute to muscle weakness in chronic airfow obstruction
    • Decramer M, Lacquet LM, Fagard R, Rogiers P. Corticosteroids contribute to muscle weakness in chronic airfow obstruction. Am J Respir Crit Care Med. 1994;150(1):11–16.
    • (1994) Am J Respir , vol.150 , Issue.1 , pp. 11-16
    • Decramer, M.1    Lacquet, L.M.2    Fagard, R.3    Rogiers, P.4
  • 15
    • 0029924786 scopus 로고    scopus 로고
    • Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease
    • Decramer M, de Bock V, Dom R. Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1996;153(6 Pt 1):1958–1964.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.6 , pp. 1958-1964
    • Decramer, M.1    De Bock, V.2    Dom, R.3
  • 16
    • 84919396177 scopus 로고    scopus 로고
    • prescribing informationOranienburg: , Nycomed GmbH, Accessed August 11, 2014
    • Daliresp® (rofumilast) tablets [prescribing information]. Oranienburg: Nycomed GmbH; 2011. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022522s000lbl.pdf. Accessed August 11, 2014.
    • (2011) ® (Rofumilast) Tablets
  • 17
    • 79953700575 scopus 로고    scopus 로고
    • Update on rofumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease
    • Rabe KF. Update on rofumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol. 2011;163(1):53–67.
    • (2011) Br J Pharmacol , vol.163 , Issue.1 , pp. 53-67
    • Rabe, K.F.1
  • 18
    • 79251588730 scopus 로고    scopus 로고
    • Reduction of exacerbations by the PDE4 inhibitor rofumilast – the importance of defning different subsets of patients with COPD
    • Rennard SI, Calverley PM, Goehring UM, Bredenbroker D, Martinez FJ. Reduction of exacerbations by the PDE4 inhibitor rofumilast – the importance of defning different subsets of patients with COPD. Respir Res. 2011;12:18.
    • (2011) Respir , vol.12 , pp. 18
    • Rennard, S.I.1    Calverley, P.M.2    Goehring, U.M.3    Bredenbroker, D.4    Martinez, F.J.5
  • 19
    • 34247618325 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of rofumilast and rofumilast N-oxide in patients with mild and moderate liver cirrhosis
    • Hermann R, Nassr N, Lahu G, et al. Steady-state pharmacokinetics of rofumilast and rofumilast N-oxide in patients with mild and moderate liver cirrhosis. Clin Pharmacokinet. 2007;46(5):403–416.
    • (2007) Clin Pharmacokinet , vol.46 , Issue.5 , pp. 403-416
    • Hermann, R.1    Nassr, N.2    Lahu, G.3
  • 20
    • 80052208536 scopus 로고    scopus 로고
    • Infu-ence of renal impairment on the pharmacokinetics of oral rofumilast: An open-label, parallel-group, single-center study
    • Bethke TD, Hartmann M, Hünnemeyer A, Lahu G, Gleiter CH. Infu-ence of renal impairment on the pharmacokinetics of oral rofumilast: an open-label, parallel-group, single-center study. Int J Clin Pharmacol Ther. 2011;49(8):491–499.
    • (2011) Int J Clin Pharmacol , vol.49 , Issue.8 , pp. 491-499
    • Bethke, T.D.1    Hartmann, M.2    Hünnemeyer, A.3    Lahu, G.4    Gleiter, C.H.5
  • 21
    • 84862290893 scopus 로고    scopus 로고
    • Selective PDE inhibitors as novel treatments for respiratory diseases
    • Page CP, Spina D. Selective PDE inhibitors as novel treatments for respiratory diseases. Curr Opin Pharmacol. 2012;12(3):275–286.
    • (2012) Curr Opin Pharmacol , vol.12 , Issue.3 , pp. 275-286
    • Page, C.P.1    Spina, D.2
  • 22
    • 77953105482 scopus 로고    scopus 로고
    • The preclinical pharmacology of rofumilast – a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
    • Hatzelmann A, Morcillo EJ, Lungarella G, et al. The preclinical pharmacology of rofumilast – a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2010;23(4):235–256.
    • (2010) Pulm Pharmacol Ther , vol.23 , Issue.4 , pp. 235-256
    • Hatzelmann, A.1    Morcillo, E.J.2    Lungarella, G.3
  • 23
    • 36749063803 scopus 로고    scopus 로고
    • Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor rofumilast in patients with COPD
    • Grootendorst DC, Gauw SA, Verhoosel RM, et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor rofumilast in patients with COPD. Thorax. 2007;62(12):1081–1087.
    • (2007) Thorax , vol.62 , Issue.12 , pp. 1081-1087
    • Grootendorst, D.C.1    Gauw, S.A.2    Verhoosel, R.M.3
  • 24
    • 47249112072 scopus 로고    scopus 로고
    • Rofumilast attenuates pulmonary infammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial
    • Hohlfeld JM, Schoenfeld K, Lavae-Mokhtari M, et al. Rofumilast attenuates pulmonary infammation upon segmental endotoxin challenge in healthy subjects: a randomized placebo-controlled trial. Pulm Pharmacol Ther. 2008;21(4):616–623.
    • (2008) Pulm , vol.21 , Issue.4 , pp. 616-623
    • Hohlfeld, J.M.1    Schoenfeld, K.2    Lavae-Mokhtari, M.3
  • 25
    • 33748642575 scopus 로고    scopus 로고
    • Investigation of a potential food effect on the pharmacokinetics of rofumilast, an oral, once-daily phosphodiesterase 4 inhibitor, in healthy subjects
    • Hauns B, Hermann R, Hünnemeyer A, et al. Investigation of a potential food effect on the pharmacokinetics of rofumilast, an oral, once-daily phosphodiesterase 4 inhibitor, in healthy subjects. J Clin Pharmacol. 2006;46(10):1146–1153.
    • (2006) J Clin Pharmacol , vol.46 , Issue.10 , pp. 1146-1153
    • Hauns, B.1    Hermann, R.2    Hünnemeyer, A.3
  • 26
    • 23744451716 scopus 로고    scopus 로고
    • Rofumilast – an oral anti-infammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial
    • Rabe KF, Bateman ED, O’Donnell D, Witte S, Bredenbröker D, Bethke TD. Rofumilast – an oral anti-infammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 2005;366(9485):563–571.
    • (2005) Lancet , vol.366 , Issue.9485 , pp. 563-571
    • Rabe, K.F.1    Bateman, E.D.2    O’Donnell, D.3    Witte, S.4    Bredenbröker, D.5    Bethke, T.D.6
  • 29
    • 69149098943 scopus 로고    scopus 로고
    • M2-127 and M2-128 study groups. Rofumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting broncho-dilators: Two randomised clinical trials
    • Fabbri LM, Calverley PM, Izquierdo-Alonso JL, et al; M2-127 and M2-128 study groups. Rofumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting broncho-dilators: two randomised clinical trials. Lancet. 2009;374(9691): 695–703.
    • (2009) Lancet , vol.374 , Issue.9691 , pp. 695-703
    • Fabbri, L.M.1    Calverley, P.M.2    Izquierdo-Alonso, J.L.3
  • 30
    • 79957513424 scopus 로고    scopus 로고
    • Rofumilast with long-acting β2-agonists for COPD: Infuence of exacerbation history
    • Bateman ED, Rabe KF, Calverley PM, et al. Rofumilast with long-acting β2-agonists for COPD: infuence of exacerbation history. Eur Respir J. 2011;38(3):553–560.
    • (2011) Eur Respir J , vol.38 , Issue.3 , pp. 553-560
    • Bateman, E.D.1    Rabe, K.F.2    Calverley, P.M.3
  • 31
    • 80155129530 scopus 로고    scopus 로고
    • Rofumilast in Asian patients with COPD: A randomized placebo-controlled trial
    • Lee SD, Hui DS, Mahayiddin AA, et al. Rofumilast in Asian patients with COPD: a randomized placebo-controlled trial. Respirology. 2011;16(8):1249–1257.
    • (2011) Respirology , vol.16 , Issue.8 , pp. 1249-1257
    • Lee, S.D.1    Hui, D.S.2    Mahayiddin, A.A.3
  • 32
    • 84892664131 scopus 로고    scopus 로고
    • Rofumilast for the treatment of COPD in an Asian population: A randomized, double-blind, parallel-group study
    • Zheng J, Yang J, Zhou X, et al. Rofumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study. Chest. 2014;145(1):44–52.
    • (2014) Chest , vol.145 , Issue.1 , pp. 44-52
    • Zheng, J.1    Yang, J.2    Zhou, X.3
  • 33
    • 84873661428 scopus 로고    scopus 로고
    • Effcacy and safety of rofumilast in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
    • Oba Y, Lone NA. Effcacy and safety of rofumilast in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Ther Adv Respir Dis. 2013;7(1):13–24.
    • (2013) Ther Adv Respir Dis , vol.7 , Issue.1 , pp. 13-24
    • Oba, Y.1    Lone, N.A.2
  • 34
    • 84871698675 scopus 로고    scopus 로고
    • Does rofumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? The REACT study protocol
    • Calverley PM, Martinez FJ, Fabbri LM, Goehring UM, Rabe KF. Does rofumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? The REACT study protocol. Int J Chron Obstruct Pulmon Dis. 2012;7:375–382.
    • (2012) Int J Chron Obstruct Pulmon Dis , vol.7 , pp. 375-382
    • Calverley, P.M.1    Martinez, F.J.2    Fabbri, L.M.3    Goehring, U.M.4    Rabe, K.F.5
  • 35
    • 34547191725 scopus 로고    scopus 로고
    • A 1-year prospective cost-effectiveness analysis of roflumilast for the treatment of patients with severe chronic obstructive pulmonary disease
    • Rutten-van Mölken MP, van Nooten FE, Lindemann M, Caeser M, Calverley PM. A 1-year prospective cost-effectiveness analysis of roflumilast for the treatment of patients with severe chronic obstructive pulmonary disease. Pharmacoeconomics. 2007;25(8): 695–711.
    • (2007) Pharmacoeconomics , vol.25 , Issue.8 , pp. 695-711
    • Rutten-Van Mölken, M.P.1    Van Nooten, F.E.2    Lindemann, M.3    Caeser, M.4    Calverley, P.M.5
  • 36
    • 84860306689 scopus 로고    scopus 로고
    • Cost-effectiveness of available treatment options for patients suffering from severe COPD in the UK: A fully incremental analysis
    • Hertel N, Kotchie RW, Samyshkin Y, Radford M, Humphreys S, Jameson K. Cost-effectiveness of available treatment options for patients suffering from severe COPD in the UK: a fully incremental analysis. Int J Chron Obstruct Pulmon Dis. 2012;7:183–199.
    • (2012) Int J Chron Obstruct Pulmon Dis , vol.7 , pp. 183-199
    • Hertel, N.1    Kotchie, R.W.2    Samyshkin, Y.3    Radford, M.4    Humphreys, S.5    Jameson, K.6
  • 37
    • 84898596300 scopus 로고    scopus 로고
    • Cost-effectiveness of rofumilast as an add-on treatment to long-acting bronchodilators in the treatment of COPD associated with chronic bronchitis in the United Kingdom
    • Samyshkin Y, Kotchie RW, Mörk AC, Briggs AH, Bateman ED. Cost-effectiveness of rofumilast as an add-on treatment to long-acting bronchodilators in the treatment of COPD associated with chronic bronchitis in the United Kingdom. Eur J Health Econ. 2014;15(1):69–82.
    • (2014) Eur J Health Econ , vol.15 , Issue.1 , pp. 69-82
    • Samyshkin, Y.1    Kotchie, R.W.2    Mörk, A.C.3    Briggs, A.H.4    Bateman, E.D.5
  • 38
    • 84859317909 scopus 로고    scopus 로고
    • Acute exacerbations of COPD in the United States: Inpatient burden and predictors of costs and mortality
    • Perera PN, Armstrong EP, Sherrill DL, Skrepnek GH. Acute exacerbations of COPD in the United States: inpatient burden and predictors of costs and mortality. COPD. 2012;9(2):131–141.
    • (2012) COPD , vol.9 , Issue.2 , pp. 131-141
    • Perera, P.N.1    Armstrong, E.P.2    Sherrill, D.L.3    Skrepnek, G.H.4
  • 39
    • 84876204648 scopus 로고    scopus 로고
    • ModifyRedBookSearch. Accessed August 11, 2014
    • Red Book Online. 2013. Available from: http://www.micromedexsolutions.com/micromedex2/librarian/PFDefaultActionId/redbook. ModifyRedBookSearch. Accessed August 11, 2014.
    • (2013) Red Book Online


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