Glial scar formation and astrocyte role in spinal cord injury

Chinese Journal of Tissue Engineering Research

Volumn 20, Issue 37, 2016, Pages 5609-5616

  Li, Jian feng ^a   Yan, Jin yu ^a   Xia, Run fu ^a   Zhang, Xu ^a   Tan, Xiao hui ^a   Guan, Jian ^a   Ye, Zhen ^a   Zhang, Shu lian ^a  

^a The Second Affiliated Hospital of Inner Mongolia Medical University   (China)

Author keywords

Astrocytes; Cicatrix; Spinal Cord Injuries

Indexed keywords

ARTICLE; ASTROCYTE; ASTROCYTOSIS; GLIA; HYPERPLASIA; SCAR FORMATION; SPINAL CORD INJURY;

EID: 85018677368     PISSN: 16738225     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.2095-4344.2016.37.020     Document Type: Article

References (62)

1. Carvalho ZMF, Darder JJT, Reis PAM, et al. Experiencing a traumatic spinal cord injury: analysis on the view of the theory of Watson’s transpersonal caring. J Biom Sci Eng. 2013;6(1):14-20.
2. Reis PA, Carvalho ZM, Tirado Darder JJ, et al. Cross-cultural adaptation of the Quality of Life Index Spinal Cord Injury-Version III. Rev Esc Enferm USP. 2015; 49(3):401-408.
3. Shamim MS, Ali SF, Enam SA. Non-operative management is superior to surgical stabilization in spine injury patients with complete neurological deficits: A perspective study from a developing world country, Pakistan. Surg NeurolInt. 2011; 2:166.
4. Nishiyama A. Polydendrocytes: NG2 cells with many roles in development and repair of the CNS. Neuroscientist. 2007;13:62-76.
5. Wilson HC, Scolding NJ, Raine CS. Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. J Neuroimmunol. 2006;176:162-173.
6. Kim SU, de Vellis J. Microglia in health and disease. J Neurosci Res. 2005;81:302-313.
7. Wu D, Zhang Y, Bo X, et al. Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons. Exp Neurol. 2007; 204:66-76.
8. Schousboe A, Westergaarde N. Transport of neuroactive amino acids in astrocytes. Neuroglia. 1995; 3:246-258.
9. Walz W. Role of glial cells in the regulation of the brain ion microenvironment. Prog Neurobiol. 1989;33: 309-333.
10. Wolburg H, Risau W. Formation of the blood-brain-barrier. Neuroglia. 1995; 11:763-776.
11. Massey JM, Hubscher CH, Wagoner MR, et al. Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. J Neurosci. 2006;26:4406-4414.
12. Tom VJ, Doller CM, Malouf AT, et al. Astrocyteassociated fibronectin is critical for axonal regeneration in adult white matter. J Neurosci. 2004;24: 9282-9290.
13. Wahlert A, Funkelstein L, Fitzsimmons B, et al. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 2013;1:1132-1139.
14. Pice DL, Ludwig JW, Mi H, et al. Distribution of rSlo Ca 2+-activated K + channels in rat astrocyte perivascular endfeet. Brain Res. 2002;956: 183-193.
15. Krzemien DM, Schaller KL, Levinson SR, et al. Immunolocalization of Sodium Channel Isoform NaCh6 in the Nervous System. J Comp Neurol. 2000; 420(1):70-83.
16. Halassa MM, Fellin T, Haydon PG. The tripartite syn-apse: roles for gliotransmission in health and disease. Trends Mol Med. 2007;13:54-63.
17. Nedergaard M, Ransom B, Goldman SA. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 2003;26:523-530.
18. Perea G, Navarrete M, Araque A. Tripartite synapses: astrocytes process and control synaptic information. Trends Neurosci. 2009;32:421-431.
19. Voskuhl RR, Peterson RS, Song B, et al. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci. 2009;29:11511-11522.
20. Volterra A, Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci. 2005;6:626-640.
21. Brown AM, Ransom BR. Astrocyte glycogen and brain energy metabolism. Glia. 2007; 55:1263-1271.
22. Pellerin L, Bouzier-Sore AK, Aubert A, et al. Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia. 2007;55:1251-1262.
23. Michael V, Sofroniew, Harry V, et al. Astrocytes: biology and pathology. Acta Neuropathol. 2010; 119:7-35.
24. Gimenez Y, Ribotta M, Menet V, et al . The role of ast rocytes in axonal regeneration in the mammalian CNS. Prog Brain Res. 2001;132: 587-610.
25. Drogemuller K, Helmuth U, Brunn A, et al. Astrocyte gp130 expression is critical for the control of Toxo-plasma encephalitis. J Immunol. 2008;181: 2683-2693.
26. Koyama Y. Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues. Neurochem Int. 2014; 78: 35-42.
27. Kozuka N, Itofusa R, Kudo Y, et al. Lipopolysaccharide and proinflammatory cytokines require different ast rocytes states to induce nitric oxide production. J Neurosci Res. 2005;82(5):717-728.
28. Lebkuechner I, Mollerstrom E, Wilhelmsson U, et al. Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency. J Neurochem. 2015;2:13202-13213.
29. Sofroniew MV. Molecular dissection of reactive as-trogliosis and glial scar formation. Trends Neurosci. 2009;32:638-647.
30. Sofroniew MV, Vinters HV. Astrocytes:biology and pathology. Acta Neuropathol. 2001;119(1):7-35.
31. Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009;32(12):638-647.
32. Wilhelmsson U, Bushong EA, Price DL, et al. Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc Natl Acad Sci USA. 2006;103: 17513-17518.
33. Herrmann JE, Imura T, Song B, et al. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci. 2008;28: 7231-7243.
34. Silver J, Miller JH. Regeneration beyond the glial scar. Nature Rev Neurosci. 2004;5:146-156.
35. Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2001;119(1):7-35.
36. Rolls A, Shechter R, Schwartz M. The bright side of the glial scar in CNS repair. Nat Rev Neurosci. 2009; 10(3):235-241.
37. Faulkner JR, Herrmann JE, Woo MJ, et al. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci. 2004;24(9):2143-2155.
38. Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci. 2004;5(2):146-156.
39. Brambilla R, Persaud T, Hu X, et al. Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J Immunol. 2009; 182(5):2628-2640.
40. Hamby ME, Hewett JA, Hewett SJ. TGF-beta1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS-2. Glia. 2006; 54(6):566-577.
41. Takano T, Kang J, Jaiswal JK, et al. Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc Natl Acad Sci U S A. 2005; 102(45):16466-16471.
42. North HA, Pan L, McGuire TL, et al. β1-Integrin alters ependymal stem cell BMP receptor localization and attenuates astrogliosis after spinal cord injury. J Neurosci. 2015;35(9):3725-33.
43. Vos PE, Jacobs B, Andriessen TM, et al. GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study. Neurology. 2010;75(20): 1786-1793.
44. Fitch MT, Silve J. Astrocytes are Dynamic Participants in Central Nervous System Development and Injury Responses. Oxford University Press. 2001;5:263-269.
45. Filbin MT. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci. 2003;4:703-713.
46. Moreau-Fauvarque C, Kumanogoh A. The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci. 2003;23:9229-9239.
47. Morgenstern DA, Asher RA, Fawcett JW. Chondroitin sulphate pro-teoglycans in the CNS injury response. Prog Brain Res. 2002;137:313-332.
48. Fitch MT, Silver J. CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol. 2008;209:294-301.
49. Carlson SL, Parrish ME, Springer JE, et al. Acute inflammatory response in spinal cord following impact injury. Exp Neurol. 1998;151:77-88.
50. Morino T, Ogata T, Horiuchi H, et al. Delayed neuronal damage related to microglia proliferation after mild spinal cord compression injury. Neurosci Res. 2003; 46: 309-318.
51. Watanabe T, Yamamoto T, Abe Y, et al. Differential activation of microglia after experimental spinal cord injury. J Neurotrauma. 1999;16:255-265.
52. Tang X. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. J Neurosci Res. 2003; 71:427-444.
53. Asher RA, Morgenstern DA, Moon LD, et al. Chondroitin sulphate proteoglycans: inhibitory components of the glial scar. Prog Brain Res. 2001; 132:611-619.
54. Yamagata T, Saito H, Habuchi O, et al. Purification and properties of bacterial chondroitinases and chondrosulfatases. J Biol Chem. 1968;243(7): 1523-1535.
55. Bradbury EJ, Carter LM. Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury. Brain Res Bull. 2011;84(4-5):306-316.
56. Pizzi MA, Crowe MJ. Matrix metalloproteinases and proteoglycans in axonal regeneration. Exp Neurol. 2007;204:496-511.
57. Yong VW. Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat Rev Neurosci. 2005; 6:931-944.
58. Jeong SR, Kwon MJ, Lee HG, et al. Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury. Exp Neurol. 2012;233(1):312-322.
59. West H, Richardson WD , Fruttiger M. Stabilization of t he retinal vascular network by reciprocal feedback between blood vessels and ast rocytes. Development. 2005;132(8):1855-1862.
60. Bradbury EJ, Moon LD, Popat RJ, et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature. 2002;416: 636-640.
61. Tan AM, Colletti M, Rorai AT, et al. Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. J Neurosci. 2006;26: 4729-4739.
62. Grimpe B, Silver J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. J Neurosci. 2004;24: 1393-1397.