Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 12, 2017, Pages 2946-2955

  Yan, Jun ^c   Hu, Jinhui ^c   Liu, Anqiu ^c   He, Lin ^a,b   Li, Xingshu ^c   Wei, Hui ^a,b  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b Guangdong Cosmetics Engineering Technology Research Center   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

AChE inhibition; Alzheimer's disease; A 1 42 self aggregation; Curcumin derivatives

Indexed keywords

1 (3 HYDROXY 4 METHOXYPHENYL) 2 [2 [1 (3 METHYLBENZYL)PIPERIDIN 4 YL]ETHYL]BUTANE 1,3 DIONE; 1 (3 HYDROXY 4 METHOXYPHENYL) 4 [1 (3 METHYLBENZYL)PIPERIDIN 4 YL]BUTANE 1,3 DIONE; 1 (3 METHOXYPHENYL) 2 [2 [1 (3 METHYLBENZYL)PIPERIDIN 4 YL]ETHYL]BUTANE 1,3 DIONE; 1 (3,4 DIMETHOXYPHENYL) 2 [2 [1 (3 METHYLBENZYL)PIPERIDIN 4YL]ETHYL]BUTANE 1,3 DIONE; 1 (4 HYDROXY 3 METHOXYPHENYL) 2 [2 [1 (3 METHYLBENZYL)PIPERIDIN 4 YL]ETHYL]BUTANE 1,3 DIONE; 1 [3 METHOXY 4 (METHOXYMETHOXY)PHENYL] 2 [2 [1 (3 METHYLBENZYL)PIPERIDIN 4 YL]ETHYL]BUTANE 1,3 DIONE; 1 [4 METHOXY 3 (METHOXYMETHOXY)PHENYL] 2 [2 [1 (3 METHYLBENZYL)PIPERIDIN 4 YL]ETHYL]BUTANE 1,3 DIONE; 1 [4 METHOXY 3 (METHOXYMETHOXY)PHENYL] 4 [1 (3 METHYLBENZYL)PIPERIDIN 4 YL]BUTANE 1,3 DIONE; 2 [(1 BENZYLPIPERIDIN 4 YL)METHYL] 1 (3 METHOXYPHENYL)BUTANE 1,3 DIONE; 2 [(1 BENZYLPIPERIDIN 4 YL)METHYL] 1 (3,4 DIMETHOXYPHENYL)BUTANE 1,3 DIONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 1 (3,4 DIMETHOXYPHENYL)BUTANE 1,3 DIONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 1 (4 HYDROXY 3 METHOXYPHENYL)BUTANE 1,3 DIONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 1 (4 METHOXYPHENYL)BUTANE 1,3 DIONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 1 [3 METHOXY 4 (METHOXYMETHOXY)PHENYL]BUTANE 1,3 DIONE; 4 (1 BENZYLPIPERIDIN 4 YL) 1 (3 HYDROXY 4 METHOXYPHENYL)BUTANE 1,3 DIONE; 4 (1 BENZYLPIPERIDIN 4 YL) 1 (3,4 DIMETHOXYPHENYL)BUTANE 1,3 DIONE; 4 (1 BENZYLPIPERIDIN 4 YL) 1 (4 METHOXYPHENYL)BUTANE 1,3 DIONE; 4 (1 BENZYLPIPERIDIN 4 YL) 1 [4 METHOXY 3 (METHOXYMETHOXY)PHENYL]BUTANE 1,3 DIONE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; CHOLINESTERASE; COPPER COMPLEX; CURCUMIN; DONEPEZIL; GALANTAMINE; METAL CHELATE; TACRINE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); CHOLINESTERASE INHIBITOR; INDAN DERIVATIVE; LIGAND; PEPTIDE FRAGMENT; PIPERIDINE DERIVATIVE; PROTEIN AGGREGATE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; DRUG DESIGN; DRUG DETERMINATION; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; IC50; IN VITRO STUDY; MEMBRANE PERMEABILITY; PROTEIN AGGREGATION; STOICHIOMETRY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; ELECTROPHORUS; ENZYMOLOGY; METABOLISM; MOLECULAR DOCKING; MOLECULARLY TARGETED THERAPY; PIG;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BLOOD-BRAIN BARRIER; CHOLINESTERASE INHIBITORS; CURCUMIN; DRUG DESIGN; ELECTROPHORUS; HUMANS; INDANS; LIGANDS; MOLECULAR DOCKING SIMULATION; MOLECULAR TARGETED THERAPY; PEPTIDE FRAGMENTS; PIPERIDINES; PROTEIN AGGREGATES; SWINE;

EID: 85018675095     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2017.02.048     Document Type: Article

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