Exploring the structure-activity relationships of [1-(4-(4- tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective δ-opioid receptor nonpeptide agonist ligand

Journal of Medicinal Chemistry

Volumn 42, Issue 26, 1999, Pages 5359-5368

  Alfaro Lopez, Josue ^a,c   Okayama, Toru ^a   Hosohata, Keiko ^b   Davis, Peg ^b   Porreca, Frank ^b   Yamamura, Henry I ^b   Hruby, Victor J ^a  

^a University of Arizona ^*  (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 TERT BUTYL 3' HYDROXYBENZHYDRYL) 2,4 DIBENZYLPIPERAZINE; 1 BENZYL 4 (4 TERT BUTYL 3' HYDROXYBENZHYDRYL)PIPERAZINE; OPIATE RECEPTOR AFFECTING AGENT; PIPERAZINE DERIVATIVE; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZHYDRYL COMPOUNDS; BRAIN; GUINEA PIGS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; MUSCLE, SMOOTH; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033620015     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990337f     Document Type: Article

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