Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica

Biotechnology and Bioengineering

Volumn 114, Issue 7, 2017, Pages 1521-1530

  Xu, Peng ^a,b   Qiao, Kangjian ^a   Stephanopoulos, Gregory ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b University of Marylandw Baltimore County   (United States)

Author keywords

aldehyde detoxification; fungal morphology; lipogenic pathway; metabolic engineering; oxidative stress; Yarrowia lipolytica

Indexed keywords

ALDEHYDES; BIOCONVERSION; CELLS; CYTOLOGY; DETOXIFICATION; FATTY ACIDS; LIPIDS; METABOLIC ENGINEERING; METABOLISM; NETWORK SECURITY; OXIDATIVE STRESS; PHYSIOLOGY; PRODUCTION PLATFORMS; PRODUCTIVITY; UNSATURATED FATTY ACIDS;

ALDEHYDE DEHYDROGENASE; ELECTROPHILIC MOLECULES; FUNGAL MORPHOLOGY; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; GLUTATHIONE DISULFIDE; LIPOGENIC PATHWAY; OVERPRODUCING STRAINS; YARROWIA LIPOLYTICA;

CELL ENGINEERING;

ALDEHYDE; ALDEHYDE DEHYDROGENASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE; LIPID;

ARTICLE; BIOPROCESS; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; FUNGAL STRAIN; LIPID OXIDATION; LIPID STORAGE; LIPOGENESIS; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; PROCESS OPTIMIZATION; REVERSE ENGINEERING; SCALE UP; YARROWIA LIPOLYTICA; BIOSYNTHESIS; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC ENHANCEMENT; GENETICS; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; PROCEDURES; YARROWIA;

ALDEHYDES; GENE EXPRESSION REGULATION, FUNGAL; GENETIC ENHANCEMENT; LIPID METABOLISM; LIPIDS; METABOLIC NETWORKS AND PATHWAYS; OXIDATIVE STRESS; YARROWIA;

EID: 85018602315     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.26285     Document Type: Article

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