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Volumn 28, Issue 4, 2017, Pages 297-310

Application of IATA–A case study in evaluating the global and local performance of a Bayesian network model for skin sensitization

Author keywords

Adverse Outcome Pathway (AOP); IATA; ITS; OECD QSAR Toolbox; QSAR; reaction domains; Skin sensitization; TIMES SS; Toxtree

Indexed keywords

BAYESIAN NETWORKS; DECISION MAKING; EXPERT SYSTEMS; INTEGRATION TESTING;

EID: 85018480249     PISSN: 1062936X     EISSN: 1029046X     Source Type: Journal    
DOI: 10.1080/1062936X.2017.1311941     Document Type: Article
Times cited : (5)

References (38)
  • 1
    • 77249164989 scopus 로고    scopus 로고
    • Corrigendum to Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC
    • The European Parliament and the Council of the European Union, Corrigendum to Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC, OJEU. L136(2007), pp. 3–280.
    • (2007) OJEU. L136 , pp. 3-280
  • 2
    • 85194972252 scopus 로고    scopus 로고
    • Regulation (EC) No 1907/2006 of the European Parliament and of the council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC
    • The European Parliament and the Council of the European Union, Regulation (EC) No 1907/2006 of the European Parliament and of the council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC, OJEU. R1907 (2006), pp. 1–101.
    • (2006) OJEU. R1907 , pp. 1-101
  • 3
    • 85194978648 scopus 로고    scopus 로고
    • National Assembly in Korea, Revised Korea REACH–The Act on the Registration and Evaluation of Chemicals, Chemical Inspection and Regulation Service (2016). Available at http://www.cirs-reach.com/news-and-articles/revised-korea-reach—the-act-on-the-registration-and-evaluation-of-chemicals.html.
    • (2016) Chemical Inspection and Regulation Service
  • 5
    • 85194974670 scopus 로고    scopus 로고
    • th Congress, Washington, DC:
    • th Congress, Washington, DC, 2016.
    • (2016) st Century Act
  • 7
    • 84940061414 scopus 로고    scopus 로고
    • In response: The path forward for the adverse outcome pathway framework—A regulatory perspective
    • D., Villeneuve, In response:The path forward for the adverse outcome pathway framework—A regulatory perspective, Environ. Toxicol. Chem. 34 (2015), pp. 1938–1940.
    • (2015) Environ. Toxicol. Chem. , vol.34 , pp. 1938-1940
    • Villeneuve, D.1
  • 9
    • 84904051395 scopus 로고    scopus 로고
    • Towards AOP application–Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization
    • G., Patlewicz, C., Kuseva, A., Kesova, I., Popova, T., Zhechev, T., Pavlov, D., Roberts, and O., Mekenyan, Towards AOP application–Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization, Regul. Toxicol. Pharmacol. 69 (2014), pp. 529–545.
    • (2014) Regul. Toxicol. Pharmacol. , vol.69 , pp. 529-545
    • Patlewicz, G.1    Kuseva, C.2    Kesova, A.3    Popova, I.4    Zhechev, T.5    Pavlov, T.6    Roberts, D.7    Mekenyan, O.8
  • 14
    • 84875627141 scopus 로고    scopus 로고
    • Artificial neural network analysis of data from multiple in vitro assays for prediction of skin sensitization potency of chemicals
    • M., Hirota, H., Kouzuki, T., Ashikaga, S., Sono, K., Tsujita, H., Sasa, and S., Aiba, Artificial neural network analysis of data from multiple in vitro assays for prediction of skin sensitization potency of chemicals, Toxicol In Vitro 27 (2013), pp. 1233–1246.
    • (2013) Toxicol In Vitro , vol.27 , pp. 1233-1246
    • Hirota, M.1    Kouzuki, H.2    Ashikaga, T.3    Sono, S.4    Tsujita, K.5    Sasa, H.6    Aiba, S.7
  • 16
    • 84904062513 scopus 로고    scopus 로고
    • Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals
    • J., van der Veen, E., Rorije, R., Emter, A., Natsch, H., van Loveren, and J., Ezendam, Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals, Regul. Toxicol. Pharmacol. 69 (2014), pp. 371–379.
    • (2014) Regul. Toxicol. Pharmacol. , vol.69 , pp. 371-379
    • van der Veen, J.1    Rorije, E.2    Emter, R.3    Natsch, A.4    van Loveren, H.5    Ezendam, J.6
  • 17
    • 84884699708 scopus 로고    scopus 로고
    • Bayesian integrated testing strategy to assess skin sensitization potency: From theory to practice
    • J., Jaworska, Y., Dancik, P., Kern, F., Gerberick, and A., Natsch, Bayesian integrated testing strategy to assess skin sensitization potency:From theory to practice, J. Appl. Toxicol. 33 (2013), pp. 1353–1364.
    • (2013) J. Appl. Toxicol. , vol.33 , pp. 1353-1364
    • Jaworska, J.1    Dancik, Y.2    Kern, P.3    Gerberick, F.4    Natsch, A.5
  • 19
    • 84949319770 scopus 로고    scopus 로고
    • Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: A decision support system for quantitative weight of evidence and adaptive testing strategy
    • J., Jaworska, A., Natsch, C., Ryan, J., Strickland, T., Ashikaga, and M., Miyazawa, Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment:A decision support system for quantitative weight of evidence and adaptive testing strategy, Arch. Toxicol. 89 (2015), pp. 2355–2383.
    • (2015) Arch. Toxicol. , vol.89 , pp. 2355-2383
    • Jaworska, J.1    Natsch, A.2    Ryan, C.3    Strickland, J.4    Ashikaga, T.5    Miyazawa, M.6
  • 22
    • 84870899568 scopus 로고    scopus 로고
    • What determines skin sensitization potency–Myths, maybes and realities. Part 1. The 500 molecular weight cut-off
    • D., Roberts, O., Mekenyan, S., Dimitrov, and G., Dimitrova, What determines skin sensitization potency–Myths, maybes and realities. Part 1. The 500 molecular weight cut-off, Contact Derm. 68 (2012), pp. 32–41.
    • (2012) Contact Derm. , vol.68 , pp. 32-41
    • Roberts, D.1    Mekenyan, O.2    Dimitrov, S.3    Dimitrova, G.4
  • 23
    • 84994184716 scopus 로고    scopus 로고
    • What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis
    • J., Fitzpatrick, D., Roberts, and G., Patlewicz, What determines skin sensitization potency:Myths, maybes and realities. The 500 molecular weight cut-off:An updated analysis, J. Appl. Toxicol. 37 (2017), pp. 105–116.
    • (2017) J. Appl. Toxicol. , vol.37 , pp. 105-116
    • Fitzpatrick, J.1    Roberts, D.2    Patlewicz, G.3
  • 24
    • 84977097675 scopus 로고    scopus 로고
    • Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization
    • J., Fitzpatrick, D., Roberts, and G., Patlewicz, Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization, J. Appl. Toxicol. 37 (2017), pp. 117–127.
    • (2017) J. Appl. Toxicol. , vol.37 , pp. 117-127
    • Fitzpatrick, J.1    Roberts, D.2    Patlewicz, G.3
  • 27
    • 42049110135 scopus 로고    scopus 로고
    • Determinants of skin sensitisation potential
    • D., Roberts and A., Aptula, Determinants of skin sensitisation potential, J. Appl. Toxicol. 28 (2008), pp. 377–387.
    • (2008) J. Appl. Toxicol. , vol.28 , pp. 377-387
    • Roberts, D.1    Aptula, A.2
  • 28
    • 53849113018 scopus 로고    scopus 로고
    • Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach
    • S., Enoch, J., Madden, and M., Cronin, Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach, SAR QSAR Environ. Res. 19 (2008), pp. 555–578.
    • (2008) SAR QSAR Environ. Res. , vol.19 , pp. 555-578
    • Enoch, S.1    Madden, J.2    Cronin, M.3
  • 29
    • 33846889946 scopus 로고    scopus 로고
    • Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay
    • D., Roberts, A., Aptula, and G., Patlewicz, Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay, Chem. Res. Toxicol. 20 (2007), pp. 44–60.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 44-60
    • Roberts, D.1    Aptula, A.2    Patlewicz, G.3
  • 31
    • 84859316945 scopus 로고    scopus 로고
    • Graphical independence networks with the gRain package for R
    • S., Højsgaard, Graphical independence networks with the gRain package for R, J. Stat. Softw. 46 (2012), pp. 1–26.
    • (2012) J. Stat. Softw. , vol.46 , pp. 1-26
    • Højsgaard, S.1
  • 32
    • 79961221925 scopus 로고    scopus 로고
    • poLCA: An R package for polytomous variable latent class analysis
    • D., Linzer and J., Lewis, poLCA:An R package for polytomous variable latent class analysis, J. Stat. Softw. 42 (2011), pp. 1–29.
    • (2011) J. Stat. Softw. , vol.42 , pp. 1-29
    • Linzer, D.1    Lewis, J.2
  • 34
    • 84942502605 scopus 로고    scopus 로고
    • Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure–activity relationships: Probabilistic hazard assessment for skin sensitization potency
    • T., Luechtefeld, A., Maertens, J., McKim, T., Hartung, A., Kleensang, and V., Sá-Rocha, Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure–activity relationships:Probabilistic hazard assessment for skin sensitization potency, J. Appl. Toxicol. 35 (2015), pp. 1361–1371.
    • (2015) J. Appl. Toxicol. , vol.35 , pp. 1361-1371
    • Luechtefeld, T.1    Maertens, A.2    McKim, J.3    Hartung, T.4    Kleensang, A.5    Sá-Rocha, V.6
  • 36
    • 84989967421 scopus 로고    scopus 로고
    • Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 3. Apparent discrepancies between LLNA and GPMT sensitization potential: False positives or differences in sensitivity?
    • D., Roberts, T., Schultz, and A., Api, Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 3. Apparent discrepancies between LLNA and GPMT sensitization potential:False positives or differences in sensitivity?, Regul. Toxicol. Pharmacol. 80 (2016), pp. 260–267.
    • (2016) Regul. Toxicol. Pharmacol. , vol.80 , pp. 260-267
    • Roberts, D.1    Schultz, T.2    Api, A.3
  • 37
    • 84859914799 scopus 로고    scopus 로고
    • The LLNA: A brief review of recent advances and limitations
    • S., Anderson, P., Siegel, and B., Meade, The LLNA:A brief review of recent advances and limitations, J. Allergy 2011 (2011), pp. 1–10.
    • (2011) J. Allergy , vol.2011 , pp. 1-10
    • Anderson, S.1    Siegel, P.2    Meade, B.3


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