A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling

Journal of Biological Chemistry

Volumn 292, Issue 18, 2017, Pages 7554-7565

  De Weerd, Nicole A ^a,b   Matthews, Antony Y ^a,b   Pattie, Phillip R ^a   Bourke, Nollaig M ^a,b   Lim, San S ^a,b   Vivian, Julian P ^b   Rossjohn, Jamie ^b,c   Hertzog, Paul J ^a,b  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CRYSTAL STRUCTURE; PLASMONS; SIGNAL TRANSDUCTION; SIGNALING; SURFACE PLASMON RESONANCE;

ANTI-PROLIFERATIVE; BINDING INTERFACE; BIOLOGICAL PROCESS; CELL-BASED ASSAYS; INTERFERON ALPHAS; INTERFERON BETAS; SIGNALING COMPLEX; SITE DIRECTED MUTAGENESIS;

GLYCOPROTEINS;

ALPHA BETA INTERFERON RECEPTOR; ALPHA BETA INTERFERON RECEPTOR SUBUNIT 1; ARGININE; BETA INTERFERON; GLUTAMINE; LEUCINE; PHENYLALANINE; STAT1 PROTEIN; THREONINE; TYROSINE; UNCLASSIFIED DRUG; VALINE; IFNAR1 PROTEIN, MOUSE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; GENE EXPRESSION; GENETIC VARIABILITY; LIGAND BINDING; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; ANIMAL; CELL LINE; GENETICS; KNOCKOUT MOUSE; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; INTERFERON-BETA; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; PROTEIN DOMAINS; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION;

EID: 85018458836     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.773788     Document Type: Article

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