The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Lin, Sue Jane ^a   Lo, Ming ^b   Kuo, Rei Lin ^a   Shih, Shin Ru ^a   Ojcius, David M ^c   Lu, Jean ^d   Lee, Chien Kuo ^b   Chen, Hui Chen ^e   Lin, Meei Yun ^a   Leu, Chuen Miin ^f   Lin, Chia Ni ^a,g   Tsai, Ching Hwa ^b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GENOMICS RESEARCH CENTER   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f NATIONAL YANG MING UNIVERSITY   (Taiwan)

^g CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

CCL12; CCL2; CCL7; Ccr2+ inflammatory monocytes; IFNAR1; Influenza A virus

Indexed keywords

ALPHA INTERFERON RECEPTOR; ALPHA INTERFERON RECEPTOR 1; CD11B ANTIGEN; CHEMOKINE RECEPTOR CCR2; OSELTAMIVIR; UNCLASSIFIED DRUG; ALPHA BETA INTERFERON RECEPTOR; ANTIVIRUS AGENT; CCR2 PROTEIN, MOUSE; CHEMOKINE; IFNAR1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE STORM; FEEDBACK SYSTEM; HIGHLY PATHOGENIC AVIAN INFLUENZA; INFLAMMATION; INNATE IMMUNITY; MONOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; GERMFREE ANIMAL; HUMAN; INFLUENZA; INFLUENZA A VIRUS (H1N1); METABOLISM; ORTHOMYXOVIRUS INFECTION; PATHOPHYSIOLOGY; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; CHEMOKINES; DISEASE MODELS, ANIMAL; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED C57BL; MONOCYTES; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, CCR2; SEVERITY OF ILLNESS INDEX; SPECIFIC PATHOGEN-FREE ORGANISMS; VIRUS REPLICATION;

EID: 84964312851     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-014-0099-6     Document Type: Article

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