Comparable potency of IFNα2 and IFNβ on immediate JAK/STAT activation but differential down-regulation of IFNAR2

Biochemical Journal

Volumn 407, Issue 1, 2007, Pages 141-151

  Marijanovic, Zrinka ^a   Ragimbeau, Josiane ^a   Van Der Heyden, José ^b,c   Uzé, Gilles ^b   Pellegrini, Sandra ^a  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

Interferon (IFN ); Interferon receptor; Interferon (IFN ); Internalization; Janus kinase (JAK); Signal transducer and activator of transcription (STAT)

Indexed keywords

BINDING ENERGY; BIOACTIVITY; ENZYMES; IMMUNOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION;

BINDING AFFINITY; JANUS KINASE (JAK); SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT); SURFACE CONCENTRATION;

INTERFERONS;

ALPHA INTERFERON RECEPTOR; ALPHA2 INTERFERON; BETA INTERFERON; JANUS KINASE; STAT PROTEIN; ALPHA BETA INTERFERON RECEPTOR; ALPHA INTERFERON; INTERFERON-ALPHA 2; LIGAND;

ARTICLE; BINDING AFFINITY; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; WESTERN BLOTTING; CELL CULTURE; GENETIC TRANSFECTION; GENETICS; HELA CELL; LEUKEMIA CELL LINE; METABOLISM; SIGNAL TRANSDUCTION; TIME;

CELLS, CULTURED; DOWN-REGULATION; HELA CELLS; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; JANUS KINASES; JURKAT CELLS; LIGANDS; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TIME FACTORS; TRANSFECTION;

EID: 35148815311     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070605     Document Type: Article

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