Mammalian target of rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease

Journal of Allergy and Clinical Immunology

Volumn 139, Issue 5, 2017, Pages 1641-1649.e6

  Gabrion, Aurélie ^a   Hmitou, Isabelle ^a   Moshous, Despina ^a,b,c   Neven, Bénédicte ^a,b,c   Lefèvre Utile, Alain ^a   Diana, Jean Sébastien ^a   Suarez, Félipe ^a,b,c   Picard, Capucine ^a,b,c   Blanche, Stéphane ^a,b   Fischer, Alain ^a,b,c,d   Cavazzana, Marina ^a,b,c   Touzot, Fabien ^a,b,c  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

^d Centre de Recherche Interdisciplinaire en Biologie   (France)

Author keywords

autophagy; Chronic granulomatous disease; IL 17A; IL 1 ; inflammasome; inflammatory manifestations; mammalian target of rapamycin inhibition

Indexed keywords

ANAKINRA; INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ADULT; ARTICLE; AUTOPHAGY; CD4+ T LYMPHOCYTE; CELL COUNT; CELL DIFFERENTIATION; CELL ISOLATION; CHILD; CHRONIC GRANULOMATOUS DISEASE; CLINICAL ARTICLE; COLITIS; CONTROLLED STUDY; CYSTITIS; CYTOKINE RELEASE; DISEASE ASSOCIATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE; MACROPHAGE; MONONUCLEAR PHAGOCYTE; NEUTROPHIL; PHAGOCYTE; PHENOTYPE; PRIORITY JOURNAL; SCHOOL CHILD; TH17 CELL; ADOLESCENT; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; IMMUNOLOGY; INFANT; INFLAMMATION; MALE; MIDDLE AGED; MONOCYTE; PRESCHOOL CHILD; YOUNG ADULT;

ADOLESCENT; ADULT; CD4-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; CYTOKINES; FEMALE; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; INFLAMMATION; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MALE; MIDDLE AGED; MONOCYTES; PHAGOCYTES; SIROLIMUS; TOR SERINE-THREONINE KINASES; YOUNG ADULT;

EID: 85018444053     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.08.033     Document Type: Article

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