메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MEMBRANE ANTIGEN;

EID: 84941551458     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13886     Document Type: Article
Times cited : (319)

References (57)
  • 1
    • 67649404131 scopus 로고    scopus 로고
    • Blood monocytes: Development, heterogeneity, and relationship with dendritic cells
    • Auffray, C., Sieweke, M. H. & Geissmann, F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 27, 669-692 (2009).
    • (2009) Annu Rev Immunol , vol.27 , pp. 669-692
    • Auffray, C.1    Sieweke, M.H.2    Geissmann, F.3
  • 2
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon, S. & Taylor, P. R. Monocyte and macrophage heterogeneity. Nat Rev Immunol 5, 953-964 (2005).
    • (2005) Nat Rev Immunol , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 3
    • 80355136629 scopus 로고    scopus 로고
    • Studying the mononuclear phagocyte system in the molecular age
    • Chow, A., Brown, B. D. & Merad, M. Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol 11, 788-798 (2011).
    • (2011) Nat Rev Immunol , vol.11 , pp. 788-798
    • Chow, A.1    Brown, B.D.2    Merad, M.3
  • 4
    • 30044434256 scopus 로고    scopus 로고
    • The mononuclear phagocyte system
    • Hume, D. A. The mononuclear phagocyte system. Curr Opin Immunol 18, 49-53 (2006).
    • (2006) Curr Opin Immunol , vol.18 , pp. 49-53
    • Hume, D.A.1
  • 5
    • 0036826744 scopus 로고    scopus 로고
    • The mononuclear phagocyte system revisited
    • Hume, D. A. et al. The mononuclear phagocyte system revisited. J Leukoc Biol 72, 621-627 (2002).
    • (2002) J Leukoc Biol , vol.72 , pp. 621-627
    • Hume, D.A.1
  • 6
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets with distinct migratory properties
    • Geissmann, F., Jung, S. & Littman, D. R. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19, 71-82 (2003).
    • (2003) Immunity , vol.19 , pp. 71-82
    • Geissmann, F.1    Jung, S.2    Littman, D.R.3
  • 7
    • 0033403066 scopus 로고    scopus 로고
    • Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
    • Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M. & Muller, W. A. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11, 753-761 (1999).
    • (1999) Immunity , vol.11 , pp. 753-761
    • Randolph, G.J.1    Inaba, K.2    Robbiani, D.F.3    Steinman, R.M.4    Muller, W.A.5
  • 8
    • 33645902493 scopus 로고    scopus 로고
    • Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    • Serbina, N. V. & Pamer, E. G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol 7, 311-317 (2006).
    • (2006) Nat Immunol , vol.7 , pp. 311-317
    • Serbina, N.V.1    Pamer, E.G.2
  • 9
    • 33846408655 scopus 로고    scopus 로고
    • Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
    • Varol, C. et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204, 171-180 (2007).
    • (2007) J Exp Med , vol.204 , pp. 171-180
    • Varol, C.1
  • 10
    • 46749135222 scopus 로고    scopus 로고
    • Blood monocytes: Distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses
    • Geissmann, F. et al. Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses. Immunol Cell Biol 86, 398-408 (2008).
    • (2008) Immunol Cell Biol , vol.86 , pp. 398-408
    • Geissmann, F.1
  • 11
    • 42649108339 scopus 로고    scopus 로고
    • Monocyte-mediated defense against microbial pathogens
    • Serbina, N. V., Jia, T., Hohl, T. M. & Pamer, E. G. Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol 26, 421-452 (2008).
    • (2008) Annu Rev Immunol , vol.26 , pp. 421-452
    • Serbina, N.V.1    Jia, T.2    Hohl, T.M.3    Pamer, E.G.4
  • 12
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • Shi, C. & Pamer, E. G. Monocyte recruitment during infection and inflammation. Nat Rev Immunol 11, 762-774 (2011).
    • (2011) Nat Rev Immunol , vol.11 , pp. 762-774
    • Shi, C.1    Pamer, E.G.2
  • 13
    • 34547730844 scopus 로고    scopus 로고
    • Monocyte subpopulations and their differentiation patterns during infection
    • Strauss-Ayali, D., Conrad, S. M. & Mosser, D. M. Monocyte subpopulations and their differentiation patterns during infection. J Leukoc Biol 82, 244-252 (2007).
    • (2007) J Leukoc Biol , vol.82 , pp. 244-252
    • Strauss-Ayali, D.1    Conrad, S.M.2    Mosser, D.M.3
  • 14
    • 0035155787 scopus 로고    scopus 로고
    • Heterogeneity of human peripheral blood monocyte subsets
    • Grage-Griebenow, E., Flad, H. D. & Ernst, M. Heterogeneity of human peripheral blood monocyte subsets. J Leukoc Biol 69, 11-20 (2001).
    • (2001) J Leukoc Biol , vol.69 , pp. 11-20
    • Grage-Griebenow, E.1    Flad, H.D.2    Ernst, M.3
  • 15
    • 84899851440 scopus 로고    scopus 로고
    • Monocyte subsets in man and other species
    • Ziegler-Heitbrock, L. Monocyte subsets in man and other species. Cell Immunol 289, 135-139 (2014).
    • (2014) Cell Immunol , vol.289 , pp. 135-139
    • Ziegler-Heitbrock, L.1
  • 16
    • 77958185103 scopus 로고    scopus 로고
    • Nomenclature of monocytes and dendritic cells in blood
    • Ziegler-Heitbrock, L. et al. Nomenclature of monocytes and dendritic cells in blood. Blood 116, e74-80 (2010).
    • (2010) Blood , vol.116 , pp. e74-80
    • Ziegler-Heitbrock, L.1
  • 17
    • 84883719725 scopus 로고    scopus 로고
    • Toward a refined definition of monocyte subsets
    • Ziegler-Heitbrock, L. & Hofer, T. P. Toward a refined definition of monocyte subsets. Front Immunol 4, 23 (2013).
    • (2013) Front Immunol , vol.4 , pp. 23
    • Ziegler-Heitbrock, L.1    Hofer, T.P.2
  • 18
    • 68549135403 scopus 로고    scopus 로고
    • Identification of novel functional differences in monocyte subsets using proteomic and transcriptomic methods
    • Zhao, C. et al. Identification of novel functional differences in monocyte subsets using proteomic and transcriptomic methods. J Proteome Res 8, 4028-4038 (2009).
    • (2009) J Proteome Res , vol.8 , pp. 4028-4038
    • Zhao, C.1
  • 20
    • 77449102329 scopus 로고    scopus 로고
    • Comparison of gene expression profiles between human and mouse monocyte subsets
    • Ingersoll, M. A. et al. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 115, e10-19 (2010).
    • (2010) Blood , vol.115 , pp. e10-19
    • Ingersoll, M.A.1
  • 21
    • 77957020717 scopus 로고    scopus 로고
    • Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    • Cros, J. et al. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 33, 375-386 (2010).
    • (2010) Immunity , vol.33 , pp. 375-386
    • Cros, J.1
  • 22
    • 70349563347 scopus 로고    scopus 로고
    • Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets
    • Ancuta, P. et al. Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. BMC Genomics 10, 403 (2009).
    • (2009) BMC Genomics , vol.10 , pp. 403
    • Ancuta, P.1
  • 23
    • 80051567423 scopus 로고    scopus 로고
    • Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets
    • Wong, K. L. et al. Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood 118, e16-31 (2011).
    • (2011) Blood , vol.118 , pp. e16-31
    • Wong, K.L.1
  • 24
    • 80053181958 scopus 로고    scopus 로고
    • SuperSAGE evidence for CD14+ + CD16+ monocytes as a third monocyte subset
    • Zawada, A. M. et al. SuperSAGE evidence for CD14+ + CD16+ monocytes as a third monocyte subset. Blood 118, e50-61 (2011).
    • (2011) Blood , vol.118 , pp. e50-61
    • Zawada, A.M.1
  • 25
    • 0030034009 scopus 로고    scopus 로고
    • Differential cytokine expression in human blood monocyte subpopulations: A polymerase chain reaction analysis
    • Frankenberger, M., Sternsdorf, T., Pechumer, H., Pforte, A. & Ziegler-Heitbrock, H. W. Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis. Blood 87, 373-377 (1996).
    • (1996) Blood , vol.87 , pp. 373-377
    • Frankenberger, M.1    Sternsdorf, T.2    Pechumer, H.3    Pforte, A.4    Ziegler-Heitbrock, H.W.5
  • 26
    • 0036533648 scopus 로고    scopus 로고
    • The proinflammatory CD14+ CD16+ DR+ + monocytes are a major source of TNF
    • Belge, K. U. et al. The proinflammatory CD14+ CD16+ DR+ + monocytes are a major source of TNF. J Immunol 168, 3536-3542 (2002).
    • (2002) J Immunol , vol.168 , pp. 3536-3542
    • Belge, K.U.1
  • 27
    • 0027365645 scopus 로고
    • The novel subset of CD14+ /CD16+ blood monocytes is expanded in sepsis patients
    • Fingerle, G. et al. The novel subset of CD14+ /CD16+ blood monocytes is expanded in sepsis patients. Blood 82, 3170-3176 (1993).
    • (1993) Blood , vol.82 , pp. 3170-3176
    • Fingerle, G.1
  • 28
    • 0031817412 scopus 로고    scopus 로고
    • Expansion of CD14+ CD16+ monocytes in critically ill cardiac surgery patients
    • Fingerle-Rowson, G. et al. Expansion of CD14+ CD16+ monocytes in critically ill cardiac surgery patients. Inflammation 22, 367-379 (1998).
    • (1998) Inflammation , vol.22 , pp. 367-379
    • Fingerle-Rowson, G.1
  • 29
    • 0036093574 scopus 로고    scopus 로고
    • CD14+ CD16+ monocytes in the course of sepsis in neonates and small children: Monitoring and functional studies
    • Skrzeczynska, J., Kobylarz, K., Hartwich, Z., Zembala, M. & Pryjma, J. CD14+ CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies. Scand J Immunol 55, 629-638 (2002).
    • (2002) Scand J Immunol , vol.55 , pp. 629-638
    • Skrzeczynska, J.1    Kobylarz, K.2    Hartwich, Z.3    Zembala, M.4    Pryjma, J.5
  • 30
    • 18944394935 scopus 로고    scopus 로고
    • Blood platelet and monocyte activations and relation to stages of liver cirrhosis
    • Panasiuk, A., Zak, J., Kasprzycka, E., Janicka, K. & Prokopowicz, D. Blood platelet and monocyte activations and relation to stages of liver cirrhosis. World J Gastroenterol 11, 2754-2758 (2005).
    • (2005) World J Gastroenterol , vol.11 , pp. 2754-2758
    • Panasiuk, A.1    Zak, J.2    Kasprzycka, E.3    Janicka, K.4    Prokopowicz, D.5
  • 31
    • 77951666930 scopus 로고    scopus 로고
    • Monocyte-platelet aggregates and platelet micro-particles in patients with post-hepatitic liver cirrhosis
    • Sayed, D., Amin, N. F. & Galal, G. M. Monocyte-platelet aggregates and platelet micro-particles in patients with post-hepatitic liver cirrhosis. Thromb Res 125, e228-233 (2010).
    • (2010) Thromb Res , vol.125 , pp. e228-233
    • Sayed, D.1    Amin, N.F.2    Galal, G.M.3
  • 32
    • 77955096540 scopus 로고    scopus 로고
    • Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
    • Zimmermann, H. W. et al. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One 5, e11049 (2010).
    • (2010) PLoS One , vol.5 , pp. e11049
    • Zimmermann, H.W.1
  • 33
    • 3042806873 scopus 로고    scopus 로고
    • Expression of Fcgamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis
    • Hepburn, A. L., Mason, J. C. & Davies, K. A. Expression of Fcgamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis. Rheumatology (Oxford) 43, 547-554 (2004).
    • (2004) Rheumatology (Oxford) , vol.43 , pp. 547-554
    • Hepburn, A.L.1    Mason, J.C.2    Davies, K.A.3
  • 34
    • 4444245592 scopus 로고    scopus 로고
    • CD14+ CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels
    • Schlitt, A. et al. CD14+ CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost 92, 419-424 (2004).
    • (2004) Thromb Haemost , vol.92 , pp. 419-424
    • Schlitt, A.1
  • 35
    • 84922393361 scopus 로고    scopus 로고
    • Filarial antigens mediate apoptosis of human monocytes through Toll-like receptor 4
    • Das Mohapatra, A. et al. Filarial antigens mediate apoptosis of human monocytes through Toll-like receptor 4. J Infect Dis 210, 1133-1144 (2014).
    • (2014) J Infect Dis , vol.210 , pp. 1133-1144
    • Das Mohapatra, A.1
  • 36
    • 84927592411 scopus 로고    scopus 로고
    • Profiling of the three circulating monocyte subpopulations in human obesity
    • Devevre, E. F. et al. Profiling of the three circulating monocyte subpopulations in human obesity. J Immunol 194, 3917-3923 (2015).
    • (2015) J Immunol , vol.194 , pp. 3917-3923
    • Devevre, E.F.1
  • 37
    • 84863538523 scopus 로고    scopus 로고
    • Impact of human granulocyte and monocyte isolation procedures on functional studies
    • Zhou, L. et al. Impact of human granulocyte and monocyte isolation procedures on functional studies. Clin Vaccine Immunol 19, 1065-1074 (2012).
    • (2012) Clin Vaccine Immunol , vol.19 , pp. 1065-1074
    • Zhou, L.1
  • 38
    • 80054768631 scopus 로고    scopus 로고
    • Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE
    • Qiu, P. et al. Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nat Biotechnol 29, 886-891 (2011).
    • (2011) Nat Biotechnol , vol.29 , pp. 886-891
    • Qiu, P.1
  • 39
    • 85191983349 scopus 로고    scopus 로고
    • From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
    • Italiani, P. & Boraschi, D. From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation. Front Immunol 5, 514 (2014).
    • (2014) Front Immunol , vol.5 , pp. 514
    • Italiani, P.1    Boraschi, D.2
  • 40
    • 84866734182 scopus 로고    scopus 로고
    • The three human monocyte subsets: Implications for health and disease
    • Wong, K. L. et al. The three human monocyte subsets: implications for health and disease. Immunol Res 53, 41-57 (2012).
    • (2012) Immunol Res , vol.53 , pp. 41-57
    • Wong, K.L.1
  • 41
    • 68149137778 scopus 로고    scopus 로고
    • Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: A prospective observational analysis
    • Poehlmann, H., Schefold, J. C., Zuckermann-Becker, H., Volk, H. D. & Meisel, C. Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. Crit Care 13, R119 (2009).
    • (2009) Crit Care , vol.13 , pp. R119
    • Poehlmann, H.1    Schefold, J.C.2    Zuckermann-Becker, H.3    Volk, H.D.4    Meisel, C.5
  • 42
    • 0021047834 scopus 로고
    • Characterization of a human blood monocyte subset with low peroxidase activity
    • Akiyama, Y. et al. Characterization of a human blood monocyte subset with low peroxidase activity. J Clin Invest 72, 1093-1105 (1983).
    • (1983) J Clin Invest , vol.72 , pp. 1093-1105
    • Akiyama, Y.1
  • 43
    • 0021964637 scopus 로고
    • Differential ability of human blood monocyte subsets to release various cytokines
    • Akiyama, Y. et al. Differential ability of human blood monocyte subsets to release various cytokines. J Leukoc Biol 37, 519-530 (1985).
    • (1985) J Leukoc Biol , vol.37 , pp. 519-530
    • Akiyama, Y.1
  • 44
    • 0021819995 scopus 로고
    • Differential interleukin-1 elaboration by density-defined human monocyte subpopulations
    • Elias, J. A., Chien, P., Gustilo, K. M. & Schreiber, A. D. Differential interleukin-1 elaboration by density-defined human monocyte subpopulations. Blood 66, 298-301 (1985).
    • (1985) Blood , vol.66 , pp. 298-301
    • Elias, J.A.1    Chien, P.2    Gustilo, K.M.3    Schreiber, A.D.4
  • 45
    • 0019955814 scopus 로고
    • Isolation of functionally different human monocytes by counterflow centrifugation elutriation
    • Figdor, C. G. et al. Isolation of functionally different human monocytes by counterflow centrifugation elutriation. Blood 60, 46-53 (1982).
    • (1982) Blood , vol.60 , pp. 46-53
    • Figdor, C.G.1
  • 46
    • 0021748677 scopus 로고
    • Subfractionation of human blood monocyte subsets with Percoll
    • Weiner, R. S. & Mason, R. R. Subfractionation of human blood monocyte subsets with Percoll. Exp Hematol 12, 800-804 (1984).
    • (1984) Exp Hematol , vol.12 , pp. 800-804
    • Weiner, R.S.1    Mason, R.R.2
  • 47
    • 0019413559 scopus 로고
    • Functions of human monocyte and lymphocyte subsets obtained by countercurrent centrifugal elutriation: Differing functional capacities of human monocyte subsets
    • Yasaka, T., Mantich, N. M., Boxer, L. A. & Baehner, R. L. Functions of human monocyte and lymphocyte subsets obtained by countercurrent centrifugal elutriation: differing functional capacities of human monocyte subsets. J Immunol 127, 1515-1518 (1981).
    • (1981) J Immunol , vol.127 , pp. 1515-1518
    • Yasaka, T.1    Mantich, N.M.2    Boxer, L.A.3    Baehner, R.L.4
  • 48
    • 0024450489 scopus 로고
    • Identification and characterization of a novel monocyte subpopulation in human peripheral blood
    • Passlick, B., Flieger, D. & Ziegler-Heitbrock, H. W. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 74, 2527-2534 (1989).
    • (1989) Blood , vol.74 , pp. 2527-2534
    • Passlick, B.1    Flieger, D.2    Ziegler-Heitbrock, H.W.3
  • 49
    • 84860241752 scopus 로고    scopus 로고
    • Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint
    • Frankenberger, M. et al. Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint. Eur J Immunol 42, 957-974 (2012).
    • (2012) Eur J Immunol , vol.42 , pp. 957-974
    • Frankenberger, M.1
  • 50
    • 84874666550 scopus 로고    scopus 로고
    • Critical assessment of automated flow cytometry data analysis techniques
    • Aghaeepour, N. et al. Critical assessment of automated flow cytometry data analysis techniques. Nat Methods 10, 228-238 (2013).
    • (2013) Nat Methods , vol.10 , pp. 228-238
    • Aghaeepour, N.1
  • 51
    • 77954250303 scopus 로고    scopus 로고
    • Data analysis in flow cytometry: The future just started
    • Lugli, E., Roederer, M. & Cossarizza, A. Data analysis in flow cytometry: the future just started. Cytometry A 77, 705-713 (2010).
    • (2010) Cytometry A , vol.77 , pp. 705-713
    • Lugli, E.1    Roederer, M.2    Cossarizza, A.3
  • 52
    • 77952515204 scopus 로고    scopus 로고
    • Comparative in vitro stimulation with lipopolysaccharide to study TNFalpha gene expression in fresh whole blood, fresh and frozen peripheral blood mononuclear cells
    • Chen, J., Bruns, A. H., Donnelly, H. K. & Wunderink, R. G. Comparative in vitro stimulation with lipopolysaccharide to study TNFalpha gene expression in fresh whole blood, fresh and frozen peripheral blood mononuclear cells. J Immunol Methods 357, 33-37 (2010).
    • (2010) J Immunol Methods , vol.357 , pp. 33-37
    • Chen, J.1    Bruns, A.H.2    Donnelly, H.K.3    Wunderink, R.G.4
  • 53
    • 57349105745 scopus 로고    scopus 로고
    • Whole-blood culture is a valid low-cost method to measure monocytic cytokines - A comparison of cytokine production in cultures of human whole-blood, mononuclear cells and monocytes
    • Damsgaard, C. T., Lauritzen, L., Calder, P. C., Kjaer, T. M. & Frokiaer, H. Whole-blood culture is a valid low-cost method to measure monocytic cytokines - a comparison of cytokine production in cultures of human whole-blood, mononuclear cells and monocytes. J Immunol Methods 340, 95-101 (2009).
    • (2009) J Immunol Methods , vol.340 , pp. 95-101
    • Damsgaard, C.T.1    Lauritzen, L.2    Calder, P.C.3    Kjaer, T.M.4    Frokiaer, H.5
  • 54
    • 0034537417 scopus 로고    scopus 로고
    • Increased levels of apoptosis of leukocyte subsets in cultured PBMCs compared to whole blood as shown by Annexin v binding: Relevance to cytokine production
    • Hodge, G., Hodge, S. & Han, P. Increased levels of apoptosis of leukocyte subsets in cultured PBMCs compared to whole blood as shown by Annexin V binding: relevance to cytokine production. Cytokine 12, 1763-1768 (2000).
    • (2000) Cytokine , vol.12 , pp. 1763-1768
    • Hodge, G.1    Hodge, S.2    Han, P.3
  • 55
    • 0033178836 scopus 로고    scopus 로고
    • Comparison of cytokine production in cultures of whole human blood and purified mononuclear cells
    • Yaqoob, P., Newsholme, E. A. & Calder, P. C. Comparison of cytokine production in cultures of whole human blood and purified mononuclear cells. Cytokine 11, 600-605 (1999).
    • (1999) Cytokine , vol.11 , pp. 600-605
    • Yaqoob, P.1    Newsholme, E.A.2    Calder, P.C.3
  • 56
    • 0037396875 scopus 로고    scopus 로고
    • 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference
    • Levy, M. M. et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29, 530-538 (2003).
    • (2003) Intensive Care Med , vol.29 , pp. 530-538
    • Levy, M.M.1
  • 57
    • 34249290789 scopus 로고    scopus 로고
    • Sepsis in the 21st century: Recent definitions and therapeutic advances
    • Nguyen, H. B. & Smith, D. Sepsis in the 21st century: recent definitions and therapeutic advances. Am J Emerg Med 25, 564-571 (2007).
    • (2007) Am J Emerg Med , vol.25 , pp. 564-571
    • Nguyen, H.B.1    Smith, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.