메뉴 건너뛰기




Volumn 97, Issue 1, 2014, Pages 20-29

Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence

Author keywords

Ex vivo expansion; Hematopoietic stem cells; Long term hematopoietic reconstitution; mTOR; Rapamycin; Senescence

Indexed keywords


EID: 84892989687     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182a7fcf8     Document Type: Article
Times cited : (66)

References (25)
  • 1
    • 0032947561 scopus 로고    scopus 로고
    • Ex vivo expansion of hema-topoietic stem and progenitor cells: Are we there yet?
    • Srour EF, Abonour R, Cornetta K, et al. Ex vivo expansion of hema-topoietic stem and progenitor cells: are we there yet? J Hematother 1999; 8: 93.
    • (1999) J Hematother , vol.8 , pp. 93
    • Srour, E.F.1    Abonour, R.2    Cornetta, K.3
  • 2
    • 0033403907 scopus 로고    scopus 로고
    • Ex vivo expansion of hematopoietic stem cells
    • Gluck S. Ex vivo expansion of hematopoietic stem cells. J Hematother Stem Cell Res 1999; 8: 575.
    • (1999) J Hematother Stem Cell Res , vol.8 , pp. 575
    • Gluck, S.1
  • 3
    • 79959461100 scopus 로고    scopus 로고
    • Ex vivo expansion of human hematopoietic stem and progenitor cells
    • Dahlberg A, Delaney C, Bernstein ID. Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood 2011; 117: 6083.
    • (2011) Blood , vol.117 , pp. 6083
    • Dahlberg, A.1    Delaney, C.2    Bernstein, I.D.3
  • 4
    • 67649595326 scopus 로고    scopus 로고
    • Identification of a stroma-mediated Wnt/beta-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche
    • Kim JA, Kang YJ, Park G, et al. Identification of a stroma-mediated Wnt/beta-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche. Stem Cells 2009; 27: 1318.
    • (2009) Stem Cells , vol.27 , pp. 1318
    • Kim, J.A.1    Kang, Y.J.2    Park, G.3
  • 5
    • 48649090483 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells
    • Huynh H, Iizuka S, Kaba M, et al. Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells 2008; 26: 1628.
    • (2008) Stem Cells , vol.26 , pp. 1628
    • Huynh, H.1    Iizuka, S.2    Kaba, M.3
  • 6
    • 0031440921 scopus 로고    scopus 로고
    • Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability
    • Miller CL, Eaves CJ. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci USA 1997; 94: 13648.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13648
    • Miller, C.L.1    Eaves, C.J.2
  • 7
    • 79956273224 scopus 로고    scopus 로고
    • Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hemato-poietic stem cells without compromising their repopulating potential
    • Khoury M, Drake A, Chen Q, et al. Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hemato-poietic stem cells without compromising their repopulating potential. Stem Cells Dev 2011; 20: 1371.
    • (2011) Stem Cells Dev , vol.20 , pp. 1371
    • Khoury, M.1    Drake, A.2    Chen, Q.3
  • 8
    • 78149280740 scopus 로고    scopus 로고
    • Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
    • Kobayashi H, Butler JM, O'Donnell R, et al. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat Cell Biol 2010; 12: 1046.
    • (2010) Nat Cell Biol , vol.12 , pp. 1046
    • Kobayashi, H.1    Butler, J.M.2    O'Donnell, R.3
  • 9
    • 0037023528 scopus 로고    scopus 로고
    • HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    • Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 2002; 109: 39.
    • (2002) Cell , vol.109 , pp. 39
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 10
    • 79959818068 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion
    • Wang Y, Kellner J, Liu L, et al. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev 2011; 20: 1143.
    • (2011) Stem Cells Dev , vol.20 , pp. 1143
    • Wang, Y.1    Kellner, J.2    Liu, L.3
  • 11
    • 84862829412 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells
    • Zou J, Zou P, Wang J, et al. Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells. Ann Hematol 2012; 91: 813.
    • (2012) Ann Hematol , vol.91 , pp. 813
    • Zou, J.1    Zou, P.2    Wang, J.3
  • 12
    • 78650510609 scopus 로고    scopus 로고
    • Sabatini DM. MTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21
    • Zoncu, R.1    Efeyan, A.2
  • 13
    • 78049496814 scopus 로고    scopus 로고
    • MTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
    • Lee JY, Nakada D, Yilmaz OH, et al. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 2010; 7: 593.
    • (2010) Cell Stem Cell , vol.7 , pp. 593
    • Lee, J.Y.1    Nakada, D.2    Yilmaz, O.H.3
  • 14
    • 72849126360 scopus 로고    scopus 로고
    • Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice
    • Huang J, Zhang Y, Bersenev A, et al. Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest 2009; 119: 3519.
    • (2009) J Clin Invest , vol.119 , pp. 3519
    • Huang, J.1    Zhang, Y.2    Bersenev, A.3
  • 15
    • 65949113818 scopus 로고    scopus 로고
    • The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells
    • Chen C, Liu Y, Liu Y, et al. The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells. Cell Cycle 2009; 8: 1158.
    • (2009) Cell Cycle , vol.8 , pp. 1158
    • Chen, C.1    Liu, Y.2    Liu, Y.3
  • 16
    • 84863011896 scopus 로고    scopus 로고
    • Rapid expansion of human he-matopoietic stem cells by automated control of inhibitory feedback signaling
    • Csaszar E, Kirouac DC, Yu M, et al. Rapid expansion of human he-matopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell 2012; 10: 218.
    • (2012) Cell Stem Cell , vol.10 , pp. 218
    • Csaszar, E.1    Kirouac, D.C.2    Yu, M.3
  • 18
    • 0034789570 scopus 로고    scopus 로고
    • Quantitative effects of Nf1 inactivation on in vivo hematopoiesis
    • Zhang Y, Taylor BR, Shannon K, et al. Quantitative effects of Nf1 inactivation on in vivo hematopoiesis. J Clin Invest 2001; 108: 709.
    • (2001) J Clin Invest , vol.108 , pp. 709
    • Zhang, Y.1    Taylor, B.R.2    Shannon, K.3
  • 19
    • 0034672240 scopus 로고    scopus 로고
    • Primitive hematopoietic stem cell function in vivo is uniquely high in the CXB-12 mouse strain
    • Chen J, Astle CM, Muller-Sieburg CE, et al. Primitive hematopoietic stem cell function in vivo is uniquely high in the CXB-12 mouse strain. Blood 2000; 96: 4124.
    • (2000) Blood , vol.96 , pp. 4124
    • Chen, J.1    Astle, C.M.2    Muller-Sieburg, C.E.3
  • 20
    • 74949127989 scopus 로고    scopus 로고
    • Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
    • Debacq-Chainiaux F, Erusalimsky JD, Campisi J, et al. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 2009; 4: 1798.
    • (2009) Nat Protoc , vol.4 , pp. 1798
    • Debacq-Chainiaux, F.1    Erusalimsky, J.D.2    Campisi, J.3
  • 21
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003; 423: 302.
    • (2003) Nature , vol.423 , pp. 302
    • Park, I.K.1    Qian, D.2    Kiel, M.3
  • 22
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen C, Liu Y, Liu R, et al. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 2008; 205: 2397.
    • (2008) J Exp Med , vol.205 , pp. 2397
    • Chen, C.1    Liu, Y.2    Liu, R.3
  • 24
    • 84870866912 scopus 로고    scopus 로고
    • Maintenance of he-matopoietic stem cells through regulation of Wnt and mTOR pathways
    • Huang J, Nguyen-McCarty M, Hexner EO, et al. Maintenance of he-matopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med 2012; 18: 1778.
    • (2012) Nat Med , vol.18 , pp. 1778
    • Huang, J.1    Nguyen-Mccarty, M.2    Hexner, E.O.3
  • 25
    • 80052403225 scopus 로고    scopus 로고
    • Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation
    • Wu XN, Wang XK, Wu SQ, et al. Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. J Biol Chem 2011; 286: 31501.
    • (2011) J Biol Chem , vol.286 , pp. 31501
    • Wu, X.N.1    Wang, X.K.2    Wu, S.Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.