p70S6K1 in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice

European Journal of Immunology

Volumn 46, Issue 1, 2016, Pages 212-222

  Sasaki, Carl Y ^a   Chen, Gang ^a   Munk, Rachel ^a   Eitan, Erez ^a   Martindale, Jennifer ^a   Longo, Dan L ^a   Ghosh, Paritosh ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

IL 17; mTOR; P70S6K1; T cell differentiation

Indexed keywords

HISTONE H3; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RETINOID RELATED ORPHAN RECEPTOR GAMMA; S6 KINASE; TRANSCRIPTION FACTOR; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; HISTONE ACETYLATION; IL 23R GENE; IL17ALPHA GENE; IL17F GENE; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CYTOLOGY; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; IMMUNOBLOTTING; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; TH2 CELLS; TOR SERINE-THREONINE KINASES;

EID: 84953837891     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445422     Document Type: Article

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