Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

Journal of Biological Chemistry

Volumn 292, Issue 18, 2017, Pages 7519-7530

  Alam, Md Morshedul ^a   Okazaki, Keito ^a   Nguyen, Linh Thi Thao ^a   Ota, Nao ^a   Kitamura, Hiroshi ^a   Murakami, Shohei ^a   Shima, Hiroki ^b,c   Igarashi, Kazuhiko ^b,c   Sekine, Hiroki ^a   Motohashi, Hozumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; ANTIOXIDANTS; BINS; CHEMICAL ACTIVATION; CHEMICAL COMPOUNDS; GENE EXPRESSION; GENES; HORMONES; SIGNALING; TRANSCRIPTION;

ANTIOXIDANT RESPONSE ELEMENTS; GLUCOCORTICOID RECEPTOR; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASE INHIBITOR; INTRACELLULAR SIGNALING; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL ACTIVATORS;

PROTEINS;

BETAMETHASONE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; HISTONE; MALEIC ACID DIETHYL ESTER; TRANSCRIPTION FACTOR NRF2; KEAP1 PROTEIN, MOUSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; PAG1 PROTEIN, MOUSE; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CHROMATIN; CONTROLLED STUDY; GENE ACTIVATION; GENE TARGETING; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER TISSUE; MALE; METABOLIC INHIBITION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ACETYLATION; ANIMAL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM;

ACETYLATION; ANIMALS; DEXAMETHASONE; HISTONES; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHOPROTEINS; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION;

EID: 85018398691     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.773960     Document Type: Article

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