메뉴 건너뛰기




Volumn 36, Issue 3, 2016, Pages 407-420

The mediator subunit MED16 transduces NRF2-Activating signals into antioxidant gene expression

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE; PROTEIN MED16; RNA POLYMERASE II; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; MED16 PROTEIN, MOUSE; MEDIATOR COMPLEX; NFE2L2 PROTEIN, MOUSE;

EID: 84958054132     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00785-15     Document Type: Article
Times cited : (67)

References (37)
  • 1
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • Motohashi H, Yamamoto M. 2004. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10:549-557. http://dx.doi.org/10.1016/j.molmed.2004.09.003.
    • (2004) Trends Mol Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 2
    • 80051545287 scopus 로고    scopus 로고
    • The Keap1-Nrf2 system as an in vivo sensor for electrophiles
    • Uruno A, Motohashi H. 2011. The Keap1-Nrf2 system as an in vivo sensor for electrophiles. Nitric Oxide 25:153-160. http://dx.doi.org/10.1016/j.niox.2011.02.007.
    • (2011) Nitric Oxide , vol.25 , pp. 153-160
    • Uruno, A.1    Motohashi, H.2
  • 6
    • 77958111633 scopus 로고    scopus 로고
    • The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
    • Malik S, Roeder RG. 2010. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 11: 761-772. http://dx.doi.org/10.1038/nrg2901.
    • (2010) Nat Rev Genet , vol.11 , pp. 761-772
    • Malik, S.1    Roeder, R.G.2
  • 7
    • 84923811117 scopus 로고    scopus 로고
    • The Mediator complex: a central integrator of transcription
    • Allen BL, Taatjes DJ. 2015. The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol 16:155-166. http://dx.doi.org/10.1038/nrm3951.
    • (2015) Nat Rev Mol Cell Biol , vol.16 , pp. 155-166
    • Allen, B.L.1    Taatjes, D.J.2
  • 8
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. 1999. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76-86. http://dx.doi.org/10.1101/gad.13.1.76.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 10
    • 84881476323 scopus 로고    scopus 로고
    • Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
    • Chowdhry S, Zhang Y, McMahon M, Sutherland C, Cuadrado A, Hayes JD. 2013. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene 32:3765-3781. http://dx.doi.org/10.1038/onc.2012.388.
    • (2013) Oncogene , vol.32 , pp. 3765-3781
    • Chowdhry, S.1    Zhang, Y.2    McMahon, M.3    Sutherland, C.4    Cuadrado, A.5    Hayes, J.D.6
  • 11
    • 0034752461 scopus 로고    scopus 로고
    • Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
    • Katoh Y, Itoh K, Yoshida E, Miyagishi M, Fukamizu A, Yamamoto M. 2001. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 6:857-868. http://dx.doi.org/10.1046/j.1365-2443.2001.00469.x.
    • (2001) Genes Cells , vol.6 , pp. 857-868
    • Katoh, Y.1    Itoh, K.2    Yoshida, E.3    Miyagishi, M.4    Fukamizu, A.5    Yamamoto, M.6
  • 13
    • 28544450507 scopus 로고    scopus 로고
    • The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
    • Nioi P, Nguyen T, Sherratt PJ, Pickett CB. 2005. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol Cell Biol 25:10895-10906. http://dx.doi.org/10.1128/MCB.25.24.10895-10906.2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 10895-10906
    • Nioi, P.1    Nguyen, T.2    Sherratt, P.J.3    Pickett, C.B.4
  • 15
    • 28144445947 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
    • Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. 2006. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 339:79-88. http://dx.doi.org/10.1016/j.bbrc.2005.10.185.
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 79-88
    • Okawa, H.1    Motohashi, H.2    Kobayashi, A.3    Aburatani, H.4    Kensler, T.W.5    Yamamoto, M.6
  • 16
    • 0034059141 scopus 로고    scopus 로고
    • DNA excision in liver by an albumin-Cre transgene occurs progressively with age
    • Postic C, Magnuson MA. 2000. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 26:149-150. http://dx.doi.org/10.1002/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V.
    • (2000) Genesis , vol.26 , pp. 149-150
    • Postic, C.1    Magnuson, M.A.2
  • 19
    • 0242474613 scopus 로고    scopus 로고
    • Isolation and functional characterization of the TRAP/mediator complex
    • Malik S, Roeder RG. 2003. Isolation and functional characterization of the TRAP/mediator complex. Methods Enzymol 364:257-284. http://dx.doi.org/10.1016/S0076-6879(03)64015-2.
    • (2003) Methods Enzymol , vol.364 , pp. 257-284
    • Malik, S.1    Roeder, R.G.2
  • 20
    • 33646580781 scopus 로고    scopus 로고
    • Mediator is a transducer of Wnt/beta-catenin signaling
    • Kim S, Xu X, Hecht A, Boyer TG. 2006. Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem 281:14066-14075. http://dx.doi.org/10.1074/jbc.M602696200.
    • (2006) J Biol Chem , vol.281 , pp. 14066-14075
    • Kim, S.1    Xu, X.2    Hecht, A.3    Boyer, T.G.4
  • 21
    • 80055101880 scopus 로고    scopus 로고
    • Staining of proteins in gels with Coomassie G-250 without organic solvent and acetic acid
    • Lawrence AM, Besir HU. 2009. Staining of proteins in gels with Coomassie G-250 without organic solvent and acetic acid. J Vis Exp 30:e1350. http://dx.doi.org/10.3791/1350.
    • (2009) J Vis Exp , vol.30
    • Lawrence, A.M.1    Besir, H.U.2
  • 22
    • 84879928007 scopus 로고    scopus 로고
    • Evaluation and optimization of mass spectrometric settings during data-dependent acquisition mode: focus on LTQ-Orbitrap mass analyzers
    • Kalli A, Smith GT, Sweredoski MJ, Hess S. 2013. Evaluation and optimization of mass spectrometric settings during data-dependent acquisition mode: focus on LTQ-Orbitrap mass analyzers. J Proteome Res 12: 3071-3086. http://dx.doi.org/10.1021/pr3011588.
    • (2013) J Proteome Res , vol.12 , pp. 3071-3086
    • Kalli, A.1    Smith, G.T.2    Sweredoski, M.J.3    Hess, S.4
  • 25
    • 0036645671 scopus 로고    scopus 로고
    • The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development
    • Ito M, Okano HJ, Darnell RB, Roeder RG. 2002. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J 21:3464-3475. http://dx.doi.org/10.1093/emboj/cdf348.
    • (2002) EMBO J , vol.21 , pp. 3464-3475
    • Ito, M.1    Okano, H.J.2    Darnell, R.B.3    Roeder, R.G.4
  • 26
    • 0037177573 scopus 로고    scopus 로고
    • Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit
    • Stevens JL, Cantin GT, Wang G, Shevchenko A, Berk AJ. 2002. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science 296:755-758. http://dx.doi.org/10.1126/science.1068943.
    • (2002) Science , vol.296 , pp. 755-758
    • Stevens, J.L.1    Cantin, G.T.2    Wang, G.3    Shevchenko, A.4    Berk, A.J.5
  • 27
    • 84884289608 scopus 로고    scopus 로고
    • One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
    • Yang H, Wang H, Shivalila CS, Cheng AW, Shi L, Jaenisch R. +2013. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell +154:1370-1379.http://dx.doi.org/10.1016/j.cell.2013.08.022.
    • (2013) Cell , vol.154 , pp. 1370-1379
    • Yang, H.1    Wang, H.2    Shivalila, C.S.3    Cheng, A.W.4    Shi, L.5    Jaenisch, R.6
  • 30
    • 2642544592 scopus 로고    scopus 로고
    • Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    • Métivier R, Penot G, Hübner MR, Reid G, Brand H, Kos M, Gannon F. 2003. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115:751-763. http://dx.doi.org/10.1016/S0092-8674(03)00934-6.
    • (2003) Cell , vol.115 , pp. 751-763
    • Métivier, R.1    Penot, G.2    Hübner, M.R.3    Reid, G.4    Brand, H.5    Kos, M.6    Gannon, F.7
  • 31
    • 0037062460 scopus 로고    scopus 로고
    • Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo
    • Sharma D, Fondell JD. 2002. Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo. Proc Natl Acad Sci U S A 99:7934-7939. http://dx.doi.org/10.1073/pnas.122004799.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7934-7939
    • Sharma, D.1    Fondell, J.D.2
  • 32
    • 70449641057 scopus 로고    scopus 로고
    • Progression through the RNA polymerase II CTD cycle
    • Buratowski S. 2009. Progression through the RNA polymerase II CTD cycle. Mol Cell 36:541-546. http://dx.doi.org/10.1016/j.molcel.2009.10.019.
    • (2009) Mol Cell , vol.36 , pp. 541-546
    • Buratowski, S.1
  • 33
    • 84862493306 scopus 로고    scopus 로고
    • Updating the RNA polymerase CTD code: adding gene-specific layers
    • Egloff S, Dienstbier M, Murphy S. 2012. Updating the RNA polymerase CTD code: adding gene-specific layers. Trends Genet 28:333-341. http://dx.doi.org/10.1016/j.tig.2012.03.007.
    • (2012) Trends Genet , vol.28 , pp. 333-341
    • Egloff, S.1    Dienstbier, M.2    Murphy, S.3
  • 34
    • 4344601432 scopus 로고    scopus 로고
    • MED16 and MED23 of Mediator are coactivators of lipopolysaccharide-and heatshock- induced transcriptional activators
    • Kim TW, Kwon YJ, Kim JM, Song YH, Kim SN, Kim YJ. +2004. MED16 and MED23 of Mediator are coactivators of lipopolysaccharide-and heatshock- induced transcriptional activators. Proc Natl Acad Sci U S A +101: 12153-12158. http://dx.doi.org/10.1073/pnas.0401985101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12153-12158
    • Kim, T.W.1    Kwon, Y.J.2    Kim, J.M.3    Song, Y.H.4    Kim, S.N.5    Kim, Y.J.6
  • 36
    • 11144232325 scopus 로고    scopus 로고
    • Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia
    • Beischlag TV, Taylor RT, Rose DW, Yoon D, Chen Y, Lee WH, Rosenfeld MG, Hankinson O. 2004. Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. J Biol Chem 279:54620-54628. http://dx.doi.org/10.1074/jbc.M410456200.
    • (2004) J Biol Chem , vol.279 , pp. 54620-54628
    • Beischlag, T.V.1    Taylor, R.T.2    Rose, D.W.3    Yoon, D.4    Chen, Y.5    Lee, W.H.6    Rosenfeld, M.G.7    Hankinson, O.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.