Reduction of whey protein concentrate antigenicity by using a combined enzymatic digestion and ultrafiltration approach

Journal of Food Science and Technology

Volumn 54, Issue 7, 2017, Pages 1910-1916

  Quintieri, Laura ^a   Monaci, Linda ^a   Baruzzi, Federico ^a   Giuffrida, Maria Gabriella ^a   de Candia, Silvia ^a   Caputo, Leonardo ^a  

^a INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

Author keywords

Antigenicity; ELISA; Enzymatic digestion; LC MS; Lactoglobulin

Indexed keywords

BIOLOGICAL MATERIALS; PAPAIN; PROTEINS; RECYCLING; ULTRAFILTRATION;

ANTIGENICITY; ELISA; ENZYMATIC DIGESTIONS; IMMUNOLOGICAL RESPONSE; IMMUNOREACTIVITIES; LACTOGLOBULIN; PEPSIN HYDROLYSATES; WHEY PROTEIN CONCENTRATE;

ANTIGENS;

EID: 85018333748     PISSN: 00221155     EISSN: 09758402     Source Type: Journal    
DOI: 10.1007/s13197-017-2625-5     Document Type: Article

References (36)

1. Baruzzi F, Pinto L, Quintieri L, Carito A, Calabrese N, Caputo L (2015) Efficacy of lactoferricin B in controlling ready-to-eat vegetable spoilage caused by Pseudomonas spp. Int J Food Microbiol 215:179–186
2. Benedé S, López-Expósito I, Giménez G, Grishina G, Bardina L, Sampson HA, López-Fandiño R, Molina E (2014) Mapping of IgE epitopes in in vitro gastroduodenal digests of β-lactoglobulin produced with human and simulated fluids. Food Res Int 62:1127–1133
3. Bertrand-Harb C, Baday A, Dalgalarrondo M, Chobert JM, Haertlé T (2002) Thermal modifications of structure and codenaturation of α -lactalbumin and β -lactoglobulin induce changes of solubility and susceptibility to proteases. Nahrung 46:283–289
4. Birsen BS, Akın N (2012) Functionality of whey protein. Int J Health Nutr 3:1–7
5. Breiteneder H, Mills ENC (2013) Food allergens-molecular and immunological characteristics. Food allergy: adverse reaction to foods and food additives. Wiley, Oxford, pp 47–99
6. Caputo L, Quintieri L, Bianchi DM, Decastelli L, Monaci L, Visconti A, Baruzzi F (2015) Pepsin-digested bovine lactoferrin prevents Mozzarella cheese blue discoloration caused by Pseudomonas fluorescens. Food Microbiol 46:15–24
7. Chen HB, Gao JY (2012) Food allergen epitopes. Multidisciplinary approaches to allergies. Springer, Berlin, pp 113–130
8. Cocco RR, Järvinen KM, Han N, Beyer K, Sampson HA (2007) Mutational analysis of immunoglobulin E-binding epitopes of β-casein and β-lactogloblulin showed a heterogeneous pattern of clinical amino acids between individual patients and pooled sera. Clin Exp Allergy 37:831–838
9. Commission Delegated Regulation (EU) 2016/127 of 25 September 2015 supplementing Regulation (EU) No 609/2013 of the European Parliament and of the Council as regards the specific compositional and information requirements for infant formula and follow-on formula and as regards requirements on information relating to infant and young child feeding
10. El Mecherfi KE, Saidi D, Kheroua O, Boudraa G, Touhami M, Rouaud O, Curet S, Choiset Y, Rabesona H, Chobert JM, Haertlé T (2011) Combined microwave and enzymatic treatments for β-lactoglobulin and bovine whey proteins and their effect on the IgE immunoreactivity. Eur Food Res Tech 233:859–867
11. HaiYing Z, Yang L, DongXue W, Jing L, Xia Z (2012) Comparison of two detection methods of β-lactoglobulin allergens in food. J Food Saf Qual 3:295–299
12. Hays T, Wood RA (2005) A systematic review of the role of hydrolyzed infant formulas in allergy prevention. Arch Pediat Adol Med 159:810–816
13. Izquierdo FJ, Peñas E, Baeza ML, Gomez R (2008) Effects of combined microwave and enzymatic treatments on the hydrolysis and immunoreactivity of dairy whey proteins. Int Dairy J 18:918–922
14. Järvinen KM, Chatchatee P, Bardina L, Beyer K, Sampson HA (2001) IgE and IgG binding epitopes on α-lactalbumin and β-lactoglobulin in cow’s milk allergy. Int Arch Allergy Immunol 126:111–118
15. Kilara A, Panyam D (2003) Peptides from milk proteins and their properties. Crit Rev Food Sci 43:607–633
16. Kim SB, Ki KS, Khan MA, Lee WS, Lee HJ, Ahn BS, Kim HS (2007) Peptic and tryptic hydrolysis of native and heated whey protein to reduce its antigenicity. J Dairy Sci 90:4043–4050
17. Lakshman PLN, Toyokawa Y, Tachibana S, Toyama H, Taira T, Yasuda M (2011) Reducing the antigenicity of milk whey protein using acid proteinases from Monascus pilosus. Proc Biochem 46:806–881
18. Lieske B, Konrad G (1996) Physico-chemical and functional properties of whey protein as affected by limited papain proteolysis and selective ultrafiltration. Int Dairy J 6:13–31
19. Mandalari G, Adel-Patient K, Barkholt V, Baro C, Bennett L, Bublin M, Mills ENC et al (2009) In vitro digestibility of β-casein and β-lactoglobulin under simulated human gastric and duodenal conditions: A multi-laboratory evaluation. Regul Toxicol Pharm 55:372–381
20. Mann B, Kumari A, Kumar R, Sharma R, Prajapati K, Mahboob S, Athira S (2015) Antioxidant activity of whey protein hydrolysates in milk beverage system. J Food Sci Tech 52:3235–3241
21. Monaci L, Visconti A (2012) Allergens. In Chemical analysis of food: techniques and applications. Academic Press (Elsevier), Waltmann MA, pp 695–716
22. Monaci L, Visconti A (2010) Immunochemical and DNA-based methods in food allergen analysis and quality assurance perspectives. Trends Food Sci Tech 21:272–283
23. Monaci L, Pilolli R, De Angelis E, Godula M, Visconti A (2014) Multi-allergen detection in food by micro high-performance liquid chromatography coupled to a dual cell linear ion trap mass spectrometry. J Chrom A 1358:136–144
24. Morris PE, Fitzgerald RJ (2008) Whey proteins and peptides in human health. Whey processing, functionality and health benefits. Wiley, Oxford, pp 285–343
25. Nakamura T, Sado H, Syukunobe Y (1993) Production of low antigenic whey protein hydrolysates by enzymatic hydrolysis and denaturation with high pressure. Milchwissenschaft 48:141–145
26. Peñas E, Restani P, Ballabio C, Préstamo G, Fiocchi A, Gomez R (2006a) Evaluation of the residual antigenicity of dairy whey hydrolysates obtained by combination of enzymatic hydrolysis and high-pressure treatment. J Food Prot 69:1707–1712
27. Peñas E, Snel H, Floris R, Préstamo G, Gomez R (2006b) High pressure can reduce the antigenicity of bovine whey protein hydrolysates. Int Dairy J 16:969–975
28. Quintieri L, Caputo L, Monaci L, Deserio D, Morea M, Baruzzi F (2012) Antimicrobial efficacy of pepsin-digested bovine lactoferrin on spoilage bacteria contaminating traditional Mozzarella cheese. Food Microbiol 31:64–71
29. Restani P, Ballabio C, Di Lorenzo C, Tripodi S, Fiocchi A (2009) Molecular aspects of milk allergens and their role in clinical events. Anal Bioanal Chem 395:47–56
30. Schutte L, Paschke A (2007) Reducing allergens in milk and milk products. Managing allergens in food. CRC Press LLC, Boca Raton, pp 159–177
31. Shi J, Luo Y, Xiao Y, Li Z, Xu Q, Yao M (2014) Effects of fermentation by Lactobacillus casei on the antigenicity and allergenicity of four bovine milk proteins. Int Dairy J 35:75–80
32. Sicherer SH, Scott H (2011) Epidemiology of food allergy. J Allergy Clin Immunol 127:594–602
33. Sircar G, Sarkar D, Bhattacharya SG, Saha S (2014) Allergen databases. Immunoinformatics. Springer, New York, pp 165–181
34. Solak BB, Akin N (2012) Health benefits of whey protein: a review. J Food Sci Eng 2:129–137
35. Villas-Boas MB, Benedé S, de Lima Zollner R, Netto FM, Molina E (2015) Epitopes resistance to the simulated gastrointestinal digestion of β-lactoglobulin submitted to two-step enzymatic modification. Food Res Int 72:191–197
36. Wróblewska B, Karamać M, Amarowicz R, Szymkiewicz A, Troszyńska A, Kubicka E (2004) Immunoreactive properties of peptide fractions of cow whey milk proteins after enzymatic hydrolysis. Int J Food Sci Tech 39:839–850