New cell models and assays in cardiac safety profiling

Expert Opinion on Drug Metabolism and Toxicology

Volumn 3, Issue 4, 2007, Pages 507-517

  Meyer, Thomas ^a   Sartipy, Peter ^b   Blind, Franziska ^c   Leisgen, Christine ^a   Guenther, Elke ^c  

^a MULTI CHANNEL SYSTEMS MCS GMBH   (Germany)

^b Cellartis   (Sweden)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Drug safety; Electrophysiology; Microelectrode arrays; QT prolongation; Safety pharmacology; Stem cells

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; DOFETILIDE; FLUORESCENT DYE; ISOPRENALINE; NEW DRUG; POTASSIUM CHANNEL HERG; RUBIDIUM; TERFENADINE; DRUG;

AUTOANALYZER; BINDING AFFINITY; CARDIOTOXICITY; DRUG BINDING; DRUG DETERMINATION; DRUG SAFETY; DRUG SCREENING; ELECTROCARDIOGRAM; ELECTROIMMUNOASSAY; EMBRYONIC STEM CELL; HEART ELECTROPHYSIOLOGY; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PATCH CLAMP; QT PROLONGATION; REPOLARIZATION; REVIEW; TISSUE SLICE; VALIDATION PROCESS; ANIMAL; CELL CULTURE; CELL LINE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ELECTROCARDIOGRAPHY; HEART DISEASE; LONG QT SYNDROME; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; CELL LINE; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; HEART DISEASES; HUMANS; LONG QT SYNDROME; PHARMACEUTICAL PREPARATIONS;

EID: 85047685425     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.3.4.507     Document Type: Review

References (80)