Teratogenic effects of the endothelin receptor antagonist L-753,037 in the rat

Reproductive Toxicology

Volumn 13, Issue 1, 1999, Pages 15-29

  Spence, Stan ^a   Anderson, Charles ^a   Cukierski, Mark ^a   Patrick, Darryl ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; Embryo; Endothelin; ET(A); ET(B); ET 3; ET 1; Fetus; Rat; Teratogenesis

Indexed keywords

ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; TERATOGENIC AGENT;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL MIGRATION; CELL PROLIFERATION; CONGENITAL MALFORMATION; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; EMBRYO DEVELOPMENT; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS DEVELOPMENT; KINETICS; LD 50; MALE; MESENCEPHALON; METABOLISM; MOUSE; NEURAL CREST CELL; NONHUMAN; PHENOTYPE; PREGNANCY; PRENATAL EXPOSURE; RAT; RAT STRAIN; RECEPTOR BINDING; REPRODUCTION; REPRODUCTIVE TOXICITY; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; KINETICS; LETHAL DOSE 50; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; REPRODUCTION; TERATOGENS;

EID: 0033066150     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(98)00064-1     Document Type: Article

References (54)

1. Moreland S. Endothelin receptor antagonsim A brief review . Can J Physiol Pharmacol. 72:1994;1469-1471.
2. Hocher B., Thone-Reineke C., Bauer C., Raschack M., Neumayer H.H. The paracrine endothelin system Pathophysiology and implications in clinical medicine . Eur J Clin Chem Clin Biochem. 35:(3):1997;175-189.
3. Battistini B., Botting R., Warner T.D. Endothelin a knockout in London . TIPS. 16:1995;217-221.
4. Warner T.D., Allock G.H., Mickley E.J., Corder R., Vane J.R. Comparative studies with the endothelin receptor antagonist BQ123 and PD 142893 indicates at least three endothelin receptors. J Cardiovasc Pharmacol. 22:(Suppl 8):1993;S117-S120.
5. Ogura K., Takayasu M., Dacey R.G. Differential effects of intra- and estraluminal endothelin on cerebral arterioles. Am J Physiol. 261:1991;H537.
6. Wagner O.F., Christ G., Woita J., Vierhaper H., Parzer S., Novotny P.J. Polar secretion of endothelin-1 in man. Circulation. 81:1990;1415-1418.
7. Kurihara Y., Kurihara H., Suzuki H., et al. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature. 368:1994;703-710.
8. A receptor gene in mice results in developmental defects in brachial region. Circulation. 90:(4):1994;I-634.
9. Clouthier D.S., Hosoda K., Richardson J.A., Williams C.A., Yanagisawa H., Kuwaki T., Kumada M., Hammer R.E., Yanagisawa. Cranial and cardiac neural crest defects in endothlin-A receptor-deficient mice. Development. 125:1998;813-824.
10. Yanagisawa H., Hammer R.E., Richardson J.A., Williams S.C., Clouthier D.E., Yanagisawa M. Role of endothelin-1/endothlin-a receptor-mediated signaling pathway in the aortic arch patterning in mice. J of Clinical Invest. 102:(1):1998;22-33.
11. Baynash AG, Hosoda K, Giaid A, Richardson JA, Emoto N, Hammer RE, Yanagisawa M. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons Cell. 1994;79:1277-85.
12. Hosoda K., Hammer R.E., Richardson J.A., Baynash A.G., Cheung J.C., Giaid A., Yanagisawa M. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell. 79:1994;1267-1276.
13. Puffenberger E.G., Hosoda K., Washington S.S., Nakao K., deWit D., Yanagisawa M., Chakravarti A. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell. 79:1994;1257-1266.
14. Attie T., Till M., Pelet A., Amiel J., Edery P., Boutrand L., Munnich A., Lyonnet S. Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease. Hum Mol Genet. 4:(12):1995;2407-2409.
15. Pavan W.J., Liddell R.A., Wright A., Thibaudeau G., Matteson P.G., McHugh K.M., Siracusa L.D. A high-resolution linkage map of the lethal spotting locus A mouse model for Hirschsprung disease . Mamm Genome. 6:1995;1-7.
16. Kapur R.P., Sweetser D.A., Doggett B., Siebert J.R., Palmiter R.D. Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts. Development. 121:1995;3787-3795.
17. Gariepy C.E., Cass D., Yanagisawa M. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proc Natl Acad Sci USA. 93:1996;867-872.
18. Wise L.D., Allen H.L., Chao-Min L.H., Verbeke D.R., Gerson R.J. Developmental neurotoxicity evaluation of Avermectin pesticide, Emamectin Benzoate, in Sprague-Dawley rats. Neurotoxicology And Teratology. 19:1997;315-326.
19. Snedecor GW, Cochran WG. Statistical methods, 7th Ed. Ames, Iowa: Iowa State University Press; 1980; Chapt 12 and 18.
20. Villars D.S. Statistical design and analysis of experiments for development research. 1951;173-177 W.C. Brown, Co, Dubuque, Iowa.
21. Harter H.L. Expected Values of Normal Order Statistics. Biometrika. 48:1961;151-165.
22. Tukey J.W. The future of data Analysis. Annals of Mathematical Statistics. 33:1962;1-67.
23. Tukey J.W., Ciminera J.L., Heyse J.F. Testing the statistical certainty of a response to increasing doses of a drug. Biometrics. 41:1985;295-301.
24. Nataf V, Grapin-Botton A, Champeval D, Amemiya A, Yanagisawa M, Le Douarin NM. The expression patterns of endothelin-A receptor and endothlin 1 in the avian embryo. Mechanisms of Development 1998;(74)145-149.
25. Imai H., Osumi-Yamashita N., Ninomiya Y., Kazuhiro E. Contribution of early-emigrating midbrain crest cells to the dental mesenchyme of mandibular molar teeth in rat embryos. Dev Biology. 176:1996;151-165.
26. Fukiishi Y., Morriss-Kay G.M. Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos. Cell Tissue Res. 268:1992;1-8.
27. Kirby M.L. Cellular and molecular contributions of the cardiac neural crest to cardiovascular development. Trends Cardiovasc Med. 3:(1):1993;18-23.
28. Kurihara Y., Kurihara H., Maemura K., Kuwaki T., Kumada M., Yazaki Y. Impaired development of the thyroid and thymus in endothelin-1 knockout mice. J Cardiovasc Pharmacol. 26:(Suppl 3):1995;S13-S16.
29. Kurihara Y., Kurihara H., Oda H., Maemura K., Nagai R., Ishikawa T., Yazaki Y. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest. 96:1995;293-300.
30. Reid K., Turnley A.M., Maxwell G.D., Kurihara Y., Kurihara H., Bartlett P.F., Murphy M. Multiple roles for endothelin in melanocyte development regulation of progenitor number and stimulation or differentiation . Development. 122:1996;3911-3919.
31. Johnston M.C., Bronsky P.T. Prenatal craniofacial development new insights on normal and abnormal mechanisms [corrected and republished article originally printed in Crit Rev Oral Biol Med 1995;6(1):25-79] . Crit Rev Oral Biol Med. 6:(4):1995;368-422.
32. Hsu L., Jeng A.Y. Growth-promoting effects of endothelin-1 and endothelin-3 on chick embryos. Brain Res. 703:1995;72-78.
33. Lahav R., Ziller C., Dupin E., Le Douarin N.M. Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. Proc Natl Acad Sci USA. 93:1996;3892-3897.
34. Yohn J.J., Smith C., Stevens T., Hoffman T.A., Morelli J.G., Hurt D.L., Yanagisawa M., Kane M.A., Zamola M.R. Human melanoma cells express functional endothelin-1 receptors. Biochem Biophys Res Commun. 201:(1):1994;449-457.
35. Noden D.M. Interactions and fates of avian craniofacial mesenchyme. Development. 103:1988.
36. Couly G.F., Coltey P.M., Le Douarin N. The triple origin of skull in higher vertebrates a study in quail-chick chimeras . Development. 117:1993;409-429.
37. Noden D.M. The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues. Dev Biol. 96:(1):1983;144-165.
38. Noden D.M. The embryonic origins of avian cephalic and cervical muscles and associated connective tissues. Am J Anat. 168:(3):1983;257-276.
39. Noden D.M. Patterning of avian craniofacial muscles. Dev Biol. 116:(2):1986;347-356.
40. Kontges G., Lumsden A. Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny. Development. 122:1996;13229-13242.
41. Hunt P., Giulisano M., Cook M., Sham M.H., Faiella A., Wilkinson D., Boncinelli E., Krumlauf R. A distinct Hox code for the branchial region of the vertebrate head. Nature. 353:1991;861-864.
42. DeSesso JM. Comparative embryology. In: Hood RD, Ed. Handbook of developmental toxicology. CRC Press Inc 1997:111-174.
43. Fujinaga M., Jackson E.C., Baden J.M. Interlitter variability and developmental stage of Day 11 rat embryos produced by overnight and morning short-period breeding regimens. Teratology. 42:(5):1990;535-540.
44. Fujinaga M., Baden J.M. Variation in development of rat embryos at the presomite period. Teratology. 45:(6):1992;661-670.
45. Kapur R.P., Livingston R., Doggett B., Sweetser D.A., Siebert J.R., Palmiter R.D. Abnormal microenvironmental signals underlie intestinal aganglionosis in Dominant megacolon mutant mice. Dev Biol. 174:1996;360-369.
46. Nataf V., Lecoin L., Eichmann A., Le Douarin N.M. Endothelin-B receptor is expressed by neural crest cells in the avian embryo. Proc Natl Acad Sci USA. 93:1996;9645-9650.
47. Inagaki H., Bishop A.E., Escrig C., Wharton J., Allen-Mersh T.G., Polak J.M. Localization of endothelinlike immunoreactivity and endothelin binding sites in human colon. Gastroenterology. 101:1991;47-54.
48. Watanabe Y., Harada T., Takahiro I., et al. Ret Proto-oncogene product is a useful marker of lineage determination in the development of the enteric nervous system in rats. J Pediatr Surg. 32:1997;28-33.
49. Cass D., Ling-Zhang A., Morthorpe J. Agangliosis in rodents. J Pediatr Surg. 27:(3):1992;351-356.
50. Mayer T.C. Enhancement of melanocyte development from piebald neural crest by a favorable tissue environment. Dev Biol. 11:1965;319-334.
51. Mayer T.C. The development of piebald spotting in mice. Dev Biol. 56:1977;255-262.
52. Gershon MD. Do developing enteric neurons need endothelins? Current Biology 195;5(6):601-604.
53. Brand M., Le Moullec J-M., Corvol P., Gasc J-M. Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme 1 in the early human embryo. J Clin Invest. 1998;101549-101559.
54. Barni T., Maggi M., Fantoni G., Serio M., Tollaro I., Gloria L., Vannelli G.B. Identification and localization of endothelin-1 and its receptors in human fetal jaws. Dev Biol. 169:1995;373-377.