The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase

Cell Reports

Volumn 19, Issue 3, 2017, Pages 451-460

  Estoppey, David ^a   Lee, Chia Min ^b   Janoschke, Marco ^c   Lee, Boon Heng ^b   Wan, Kah Fei ^b   Dong, Hongping ^b   Mathys, Philippe ^a   Filipuzzi, Ireos ^a   Schuhmann, Tim ^a   Riedl, Ralph ^a   Aust, Thomas ^a   Galuba, Olaf ^a   McAllister, Gregory ^d   Russ, Carsten ^d   Spiess, Martin ^c   Bouwmeester, Tewis ^a   Bonamy, Ghislain M C ^b   Hoepfner, Dominic ^a,c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^c UNIVERSITY OF BASEL   (Switzerland)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

cavinafungin; chemogenomic profiling; CRISPR Cas9; dengue virus; SEC11; SEC11A; signal peptidase; Zika virus

Indexed keywords

ANTIVIRUS AGENT; CAVINAFUNGIN; NATURAL PRODUCT; SIGNAL PEPTIDASE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; LIPOPEPTIDE; MEMBRANE PROTEIN; PROTEIN SUBUNIT; SERINE PROTEINASE; TYPE I SIGNAL PEPTIDASE; VIRAL PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; CRISPR CAS SYSTEM; DENGUE VIRUS; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; FUNGUS MUTATION; GENE EXPRESSION PROFILING; GENOME ANALYSIS; HUMAN; HUMAN CELL; NONHUMAN; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION; ZIKA VIRUS; CHEMISTRY; DRUG EFFECTS; GENE SILENCING; GENETICS; GENOMICS; HCT 116 CELL LINE; HUMAN GENOME; METABOLISM; PHYSIOLOGY; PROTEIN SUBUNIT;

BIOLOGICAL PRODUCTS; CRISPR-CAS SYSTEMS; DENGUE VIRUS; GENE KNOCKDOWN TECHNIQUES; GENOME, HUMAN; GENOMICS; HCT116 CELLS; HUMANS; LIPOPEPTIDES; MEMBRANE PROTEINS; PROTEIN SUBUNITS; SACCHAROMYCES CEREVISIAE; SERINE ENDOPEPTIDASES; VIRAL PROTEINS; VIRUS REPLICATION; ZIKA VIRUS;

EID: 85017646246     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.03.071     Document Type: Article

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