Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma

International Journal of Medical Sciences

Volumn 12, Issue 3, 2015, Pages 256-263

  Yang, Zongguo ^a   Zhuang, Liping ^a,b   Szatmary, Peter ^c,d   Wen, Li ^c,d   Sun, Hua ^a   Lu, Yunfei ^a   Xu, Qingnian ^a   Chen, Xiaorong ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

BCLC stage; Carcinoma; Cirrhosis; Heat shock proteins; Hepatocellular; HSP70; HSP90B1; HSPA12A; HSPA4; HSPA5; HSPA6; Recurrence; Survival

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90B1; HEAT SHOCK PROTEIN A12A; HEAT SHOCK PROTEIN A13; HEAT SHOCK PROTEIN A14; HEAT SHOCK PROTEIN A1A; HEAT SHOCK PROTEIN A1B; HEAT SHOCK PROTEIN A1L; HEAT SHOCK PROTEIN A2; HEAT SHOCK PROTEIN A4; HEAT SHOCK PROTEIN A5; HEAT SHOCK PROTEIN A6; HEAT SHOCK PROTEIN A8; HEAT SHOCK PROTEIN A9; HEAT SHOCK PROTEIN AA1; HEAT SHOCK PROTEIN AB1; HEAT SHOCK PROTEIN B11; HEAT SHOCK PROTEIN B2; HEAT SHOCK PROTEIN B3; HEAT SHOCK PROTEIN B6; HEAT SHOCK PROTEIN B7; HEAT SHOCK PROTEIN BAP1; HEAT SHOCK PROTEIN BP1; HEAT SHOCK PROTEIN H1; UNCLASSIFIED DRUG; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN 110; HEAT SHOCK PROTEIN 70; HSP70B' PROTEIN, HUMAN; HSPA12A PROTEIN, HUMAN; HSPA4 PROTEIN, HUMAN; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78;

ADULT; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; UPREGULATION; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; LIVER TUMOR; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; PROGNOSIS; TREATMENT OUTCOME;

ADULT; CARCINOMA, HEPATOCELLULAR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HEPATITIS B VIRUS; HSP110 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; TREATMENT OUTCOME;

EID: 84923002608     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.10735     Document Type: Article

References (43)

1. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002: Cancer incidence, mortality and prevalence worldwide IARC. (Cancer Base No.5 Version 2.0). Lyon, France: IARCPress. 2004.
2. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001,2(9):533-543.
3. Shariff MI, Cox IJ, Gomaa AI, Khan SA, Gedroyc W, Taylor-Robinson SD. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics. Expert Rev Gastroenterol Hepatol 2009,3(4):353-367.
4. Siegel R, Naishadham D, Jemal A. Cancer Statistics, 2012. CA Cancer J Clin 2012,62:10-29.
5. Yao DF, Dong ZZ, Yao M. Specific molecular markers in hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2007,6(3):241-247.
6. Lim SO, Park SG, Yoo JH, et al. Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. World J Gastroenterol 2005,11(14):2072-2079.
7. Cui N, Xu YP, Cao ZH, Xu FX, Zhang P, Jin LJ. Effects of heat stress on the level of heat shock protein 70 on the surface of hepatocellular carcinoma Hep G2 cells: implications for the treatment of tumors. Tumor Biol 2013,34(2):743-8.
8. Cawthorn TR, Moreno JC, Dharsee M, et al. Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival. PLoS One 2012,7(2):e30992.
9. Jego G, Hazoumé A, Seigneuric R, Garrido C. Targeting heat shock proteins in cancer. Cancer Lett 2013,332(2):275-85.
10. Ciocca DR, Cayado-Gutierrez N, Maccioni M, Cuello-Carrion FD. Heat Shock Proteins (HSPs) Based Anti-Cancer Vaccines. Curr Mol Med 2012,12(9):1183-97.
11. Luk JM, Lam CT, Siu AFM, et al. Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values. Proteomics 2006,6:1049-1057.
12. Qin LX, Tang ZY. Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: a review of the literature. J Cancer Res Clin Oncol 2004,130:497-513.
13. Roessler S, Jia HL, Budhu A, et al. A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients. Cancer Res 2010,70(24):10202-12.
14. Roessler S, Long EL, Budhu A, et al. Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology 2012,142(4):957-966.
15. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR. Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci 2006,31(3):164-72.
16. Chen YC, Lin-Shiau SY, Lin JK. Involvement of heat-shock protein 70 and p53 proteins in attenuation of UVC-induced apoptosis by thermal stress in hepatocellular carcinoma cells. Photochem Photobiol 1999,70(1):78-86.
17. Han ZH, Truong QA, Park S, Breslow JL. Two Hsp70 family members expressed in atherosclerotic lesions. Proc Natl Acad Sci USA 2003,100(3):1256-61.
18. You LP, Ning XX, Liu F, Zhao JM, Wang Q, Wu HF. The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge. Fish Shellfish Immunol 2013,35(2):343-50.
19. Masoudi AA, Uchida K, Yokouchi K, et al. Linkage mapping of the locus responsible for forelimb-girdle muscular anomaly of Japanese black cattle on bovine chromosome 26. Anim Genet 2008,39(1):46-50.
20. Zhu YF, Ren CL, Wang XY, et al. Gene expression of Hsp70, Hsp90 and Hsp110 families in normal palate and cleft palate during mouse embryogenesis. Toxicol Ind Health 2013,29(10):915-30.
21. Effendi K, Sakamoto M. Molecular pathology in early hepatocarcinogenesis. Oncology 2010,78(2):157-60.
22. Sakamoto M, Mori T, Masugi Y, Effendi K, Rie I, Du W. Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma. Intervirology 2008,51(Suppl 1):42-5.
23. Chuma M, Sakamoto M, Yamazaki K, et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 2003,37(1):198-207.
24. Workman P, Burrows F, Neckers L, Rosen N. Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann N Y Acad Sci 2007,1113:202-216.
25. Li GD, Cai M, Fu D, et al. Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. Cell Physiol Biochem 2012,30(6):1481-90.
26. Cawthorn TR, Moreno JC, Dharsee M, et al. Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival. PLoS One 2012,7(2):e30992.
27. Yedavelli SP, Guo L, Daou ME, Srivastava PK, Mittelman A, Tiwari RK. Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model. Int J Mol Med 1999,4(3):243-8.
28. Kovalchin JT, Murthy AS, Horattas MC, Guyton DP, Chandawarkar RY. Determinants of efficacy of immunotherapy with tumor-derived heat shock protein gp96. Cancer Immun 2001,1:7-15.
29. Arnold-Schild D, Kleist C, Welschof M, et al. One-step single-chain Fv recombinant antibody-based purification of gp96 for vaccine development. Cancer Res 2000, 60(15):4175-8.
30. Randazzo M, Terness P, Opelz G, Kleist C. Active-specific immunotherapy of human cancers with the heat shock protein Gp96-revisited. Int J Cancer 2012,130(10):2219-31.
31. Udono H, Srivastava PK. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp 70. J Immunol 1994,152(11):5398-403.
32. Meng SD, Gao T, Gao GF, Tien P. HBV-specific peptide associated with heat-shock protein gp 96. Lancet 2001,357(9255):528-9.
33. Meng SD, Song J, Rao Z, Tien P, Gao GF. Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides. J Immunol Methods 2002,264(1-2):29-35.
34. Tanaka K, Kondoh N, Shuda M, et al. Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas. Biochim Biophys Acta 2001,1536(1):1-12.
35. Zhu XD, Li CL, Lang ZW, Gao GF, Tien P. Significant correlation between expression level of HSP gp96 and progression of hepatitis B virus induced diseases. World J Gastroenterol 2004,10(8):1141-5.
36. Yang MH, Chang SY, Chiou SH, et al. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene 2007,26(10):1459-67.
37. Wu CY, Lin CT, Wu MZ, Wu KJ. Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity. J Biomed Sci 2011,18:1.
38. Su RJ, Li Z, Li HD, et al. Grp78 promotes the invasion of hepatocellular carcinoma. BMC Cancer 2010,10:20.
39. Li HD, Song HJ, Luo JS, Liang J, Zhao S, Su RJ. Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells. J Exp Clin Cancer Res 2012,31:39.
40. Wang XP, Zhou YX, Sun LJ, et al. Complex formation between heat shock protein 72 and hepatitis B virus X protein in hepatocellular carcinoma tissues. J Proteome Res 2008,7(12):5133-7.
41. Kim BK, Kim SU, Park JY, et al. Applicability of BCLC stage for prognostic stratification in comparison with other staging systems: single centre experience from long-term clinical outcomes of 1717 treatment-naïve patients with hepatocellular carcinoma. Liver Int 2012,32(7):1120-7.
42. Guglielmi A, Ruzzenente A, Pachera S, et al. Comparison of seven staging systems in cirrhotic patients with hepatocellular carcinoma in a cohort of patients who underwent radiofrequency ablation with complete response. Am J Gastroenterol 2008,103(3):597-604.
43. Hernandez-Gea V, Toffanin S, Friedman SL, Llovet JM. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology 2013,144(3):512-27.