Genetic signatures of high-altitude adaptation in Tibetans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 16, 2017, Pages 4189-4194

  Yang, Jian ^a,b   Jin, Zi Bing ^b   Chen, Jie ^b   Huang, Xiu Feng ^b   Li, Xiao Man ^b   Liang, Yuan Bo ^b   Mao, Jian Yang ^b   Chen, Xin ^b   Zheng, Zhili ^a,b   Bakshi, Andrew ^a   Zheng, Dong Dong ^b   Zheng, Mei Qin ^b   Wray, Naomi R ^a   Visscher, Peter M ^a   Lu, Fan ^b   Qu, Jia ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Genome wide association study; High altitude adaptation; Mixed linear model; Polygenic selection; Tibetans

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HEMOGLOBIN; HOMOCYSTEINE;

ALLELE; ALTITUDE ACCLIMATIZATION; ARTICLE; EAST ASIAN; ERYTHROCYTE COUNT; EVOLUTIONARY ADAPTATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC DRIFT; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; GENOTYPE; GENOTYPING TECHNIQUE; HEMATOCRIT; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; POPULATION STRUCTURE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TIBETAN (PEOPLE); ULTRAVIOLET RADIATION; ADAPTATION; ALTITUDE; ETHNIC GROUP; FEMALE; GENETIC MARKER; GENETIC SELECTION; GENETICS; MALE; TIBET;

ADAPTATION, PHYSIOLOGICAL; ALLELES; ALTITUDE; ETHNIC GROUPS; FEMALE; GENETIC MARKERS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; PHENOTYPE; SELECTION, GENETIC; TIBET;

EID: 85017613592     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1617042114     Document Type: Article

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