Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens

Cell Reports

Volumn 19, Issue 3, 2017, Pages 569-583

  Chen, Guobing ^a   Yang, Xinbo ^b,c   Ko, Annette ^a   Sun, Xiaoping ^a   Gao, Mingming ^b,c   Zhang, Yongqing ^a   Shi, Alvin ^a   Mariuzza, Roy A ^b,c   Weng, Nan ping ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^c Bldg 142   (United States)

Author keywords

CD8 T cells; human; TCR repertoire; TCR pMHC structure; TCRs for CMV NLV; TCRs for IAV GIL

Indexed keywords

CD8 ANTIGEN; CDR3ALPHA PROTEIN; CDR3BETA PROTEIN; CELL PROTEIN; CYTOMEGALOVIRUS ANTIGEN PP65; EPITOPE; GIL ANTIGEN; HLA A2 ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN; COMPLEMENTARITY DETERMINING REGION; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE; PROTEIN BINDING;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; INFLUENZA A VIRUS; MOLECULAR CLONING; NONHUMAN; PREDICTION; PROTEIN MOTIF; PROTEIN STRUCTURE; RAT; VIRUS CELL INTERACTION; ANTIBODY AFFINITY; CD8+ T LYMPHOCYTE; CELL CLONE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; CONSENSUS SEQUENCE; IMMUNOLOGY; METABOLISM; SPECIES DIFFERENCE;

ADULT; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; CONSENSUS SEQUENCE; CYTOMEGALOVIRUS; HLA-A2 ANTIGEN; HUMANS; IMMUNODOMINANT EPITOPES; INFLUENZA A VIRUS; PEPTIDES; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; SPECIES SPECIFICITY;

EID: 85017590386     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.03.072     Document Type: Article

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