Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8+ T cell receptor alpha repertoire following allogeneic transplantation

Clinical and Experimental Immunology

Volumn 184, Issue 3, 2016, Pages 389-402

  Link, C S ^a,b   Eugster, A ^b   Heidenreich, F ^a   Rucker Braun E ^a   Schmiedgen, M ^a   Oelschlagel U ^a   Kuhn D ^b   Dietz, S ^b   Fuchs, Y ^b   Dahl, A ^b,c   Domingues, A M J ^b   Klesse, C ^d   Schmitz, M ^b,c   Ehninger, G ^a,b   Bornhauser M ^a,b   Schetelig, J ^a,d   Bonifacio, E ^b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d DKMS Clinical Trials Unit   (Germany)

Author keywords

Allogeneic transplantation; CMV; Next generation sequencing; T cell receptor alpha; T cell receptor repertoire

Indexed keywords

ACICLOVIR; BUSULFAN; CLOFARABINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; GAMMA INTERFERON; GLUCOCORTICOID; GRANZYME A; GRANZYME B; HLA A ANTIGEN; MELPHALAN; METHOTREXATE; MYCOPHENOLATE MOFETIL; OFATUMUMAB; PREDNISOLONE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; THYMOCYTE ANTIBODY; VALGANCICLOVIR; EPITOPE; HLA A2 ANTIGEN; HLA-A*02:01 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; VIRUS ANTIGEN;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE MYELOBLASTIC LEUKEMIA; ADULT; AGED; ALLOTRANSPLANTATION; ARTICLE; CASE REPORT; CD8+ T LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DRUG MEGADOSE; ENTERITIS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HLA MATCHING; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTESTINE BIOPSY; MALE; MEMORY T LYMPHOCYTE; MIDDLE AGED; MYELOABLATIVE CONDITIONING; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REDUCED INTENSITY CONDITIONING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL DEPLETION; TREATMENT DURATION; ADVERSE EFFECTS; AMINO ACID SEQUENCE; CELL CLONE; CYTOMEGALOVIRUS INFECTIONS; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKEMIA, MYELOID, ACUTE; PATHOLOGY; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; VIROLOGY;

AGED; AMINO ACID SEQUENCE; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; EPITOPES; FEMALE; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA-A2 ANTIGEN; HUMANS; IMMUNOLOGIC MEMORY; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84960456528     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12770     Document Type: Article

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