Quantitating T cell cross-reactivity for unrelated peptide antigens

Journal of Immunology

Volumn 183, Issue 7, 2009, Pages 4337-4345

  Ishizuka, Jeffrey ^a,b   Grebe, Kristie ^a   Shenderov, Eugene ^a,b   Peters, Bjoern ^c   Chen, Qiongyu ^b   Peng, YanChun ^b   Wang, Lili ^b   Dong, Tao ^b   Pasquetto, Valerie ^c   Oseroff, Carla ^c   Sidney, John ^c   Hickman, Heather ^a   Cerundolo, Vincenzo ^b   Sette, Alessandro ^c   Bennink, Jack R ^a   McMichael, Andrew ^b   Yewdell, Jonathan W ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR; EPITOPE; PEPTIDE FRAGMENT; PEPTIDE LIBRARY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS REACTION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; POXVIRUS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; T LYMPHOCYTE; VIRUS; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CLONE; CROSS PRESENTATION; DRUG POTENTIATION; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; PREDICTION AND FORECASTING; PROTEIN BINDING; TRANSGENIC MOUSE; TUMOR CELL LINE; VIROLOGY;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CLONE CELLS; CROSS REACTIONS; CROSS-PRIMING; EPITOPES, T-LYMPHOCYTE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING;

EID: 70449732759     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901607     Document Type: Article

References (38)

1. Manning, T. C., C. J. Schlueter, T. C. Brodnicki, E. A. Parke, J. A. Speir, K. C. Garcia, L. Teyton, I. A. Wilson, and D. M. Kranz. 1998. Alanine scanning mutagenesis of an αβT cell receptor: mapping the energy of antigen recognition. Immunity 8: 413-425.
2. Hao, Y., N. Legrand, and A. A. Freitas. 2006. The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J. Exp. Med. 203: 1643-1649. (Pubitemid 44036268)
3. Kim, S. K., M. Cornberg, X. Z. Wang, H. D. Chen, L. K. Selin, and R. M. Welsh. 2005. Private specificities of CD8 T cell responses control patterns of heterologous immunity. J. Exp. Med. 201: 523-533.
4. Crawford, F., E. Huseby, J. White, P. Marrack, and J. W. Kappler. 2004. Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. PLoS Biol. 2: e90. (Pubitemid 39234510)
5. 777-85 CTL response. J. Immunol. 176: 6690-6701.
6. Nino-Vasquez, J. J., G. Allicotti, E. Borras, D. B. Wilson, D. Valmori, R. Simon, R. Martin, and C. Pinilla. 2004. A powerful combination: the use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes. Mol. Immunol. 40: 1063-1074.
7. Oseroff, C., F. Kos, H. H. Bui, B. Peters, V. Pasquetto, J. Glenn, T. Palmore, J. Sidney, D. C. Tscharke, J. R. Bennink, et al. 2005. HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation. Proc. Natl. Acad. Sci. USA 102: 13980-13985.
8. Pasquetto, V., H. H. Bui, R. Giannino, C. Banh, F. Mirza, J. Sidney, C. Oseroff, D. C. Tscharke, K. Irvine, J. R. Bennink, et al. 2005. HLA-A*0201, HLAA*-1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products. J. Immunol. 175: 5504-5515. (Pubitemid 41456438)
9. Doolan, D. L., S. Southwood, D. A. Freilich, J. Sidney, N. L. Graber, L. Shatney, L. Bebris, L. Florens, C. Dobano, A. A. Witney, et al. 2003. Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc. Natl. Acad. Sci. USA 100: 9952-9957.
10. Sette, A., and J. Sidney. 1999. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics 50: 201-212.
11. Lee, J. K., G. Stewart-Jones, T. Dong, K. Harlos, K. Di Gleria, L. Dorrell, D. C. Douek, P. A. van der Merwe, E. Y. Jones, and A. J. McMichael. 2004. T cell cross-reactivity and conformational changes during TCR engagement. J. Exp. Med. 200: 1455-1466.
12. Christinck, E. R., M. A. Luscher, B. H. Barber, and D. B. Williams. 1991. Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis. Nature 352: 67-70.
13. Yewdell, J. W., and J. R. Bennink. 1999. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu. Rev. Immunol. 17: 51-88.
14. 2m double knockout mice. J. Exp. Med. 185: 2043-2051.
15. + T cell responses. Immunity 25: 533-543.
16. Kedzierska, K., N. L. La Gruta, J. Stambas, S. J. Turner, and P. C. Doherty. 2008. Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Mol. Immunol. 45: 607-618.
17. + memory T cell repertoire could optimize potential for immune responses. J. Immunol. 170: 3994-4001.
18. + T cells by viral and tumor antigens is a robust phenomenon. Eur. J. Immunol. 34: 194-199.
19. Anderson, R. W., J. R. Bennink, J. W. Yewdell, W. L. Maloy, and J. E. Coligan. 1992. Influenza basic polymerase 2 peptides are recognized by influenza nucleoprotein-specific cytotoxic T lymphocytes. Mol. Immunol. 29: 1089-1096.
20. + T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection. Semin. Immunol. 16: 179-184.
21. Oseroff, C., B. Peters, V. Pasquetto, M. Moutaftsi, J. Sidney, V. Panchanathan, D. C. Tscharke, B. Maillere, H. Grey, and A. Sette. 2008. Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus Western Reserve. J. Immunol. 180: 7193-7202.
22. Garcia, K. C., L. Teyton, and I. A. Wilson. 1999. Structural basis of T cell recognition. Annu. Rev. Immunol. 17: 369-397.
23. Wedemeyer, H., E. Mizukoshi, A. R. Davis, J. R. Bennink, and B. Rehermann. 2001. Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells. J. Virol. 75: 11392-11400. (Pubitemid 33063230)
24. + T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J. Clin. Invest. 115: 3602-3612.
25. + T cells dominate the memory compartments of exposed subjects. J. Exp Med. 202: 673-685.
26. Lindahl, K. F., and D. B. Wilson. 1977. Histocompatibility antigen-activated cytotoxic T lymphocytes, II: Estimates of the frequency and specificity of precursors. J. Exp. Med. 145: 508-522. (Pubitemid 8049606)
27. Sherman, L. A., and S. Chattopadhyay. 1993. The molecular basis of allorecognition. Annu. Rev. Immunol. 11: 385-402.
28. Overwijk, W. W., A. Tsung, K. R. Irvine, M. R. Parkhurst, T. J. Goletz, K. Tsung, M. W. Carroll, C. Liu, B. Moss, S. A. Rosenberg, and N. P. Restifo. 1998. gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand. J. Exp. Med. 188: 277-286.
29. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27. (Pubitemid 24035278)
30. Mamalaki, C., J. Elliott, T. Norton, N. Yannoutsos, A. R. Townsend, P. Chandler, E. Simpson, and D. Kioussis. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev. Immunol. 3: 159-174.
31. + thymocytes. Nature 333: 742-746.
32. + T cells. J. Exp. Med. 198: 569-580.
33. Gotch, F., A. McMichael, G. Smith, and B. Moss. 1987. Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes. J. Exp. Med. 165: 408-416. (Pubitemid 17019824)
34. Ishizuka, J., G. B. Stewart-Jones, A. van der Merwe, J. I. Bell, A. J. McMichael, and E. Y. Jones. 2008. The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vβ domain. Immunity 28: 171-182.
35. Iversen, A. K., G. Stewart-Jones, G. H. Learn, N. Christie, C. Sylvester-Hviid, A. E. Armitage, R. Kaul, T. Beattie, J. K. Lee, Y. Li, et al. 2006. Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope. Nat. Immunol. 7: 179-189.
36. Johnson, R. P., A. Trocha, L. Yang, G. P. Mazzara, D. L. Panicali, T. M. Buchanan, and B. D. Walker. 1991. HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes: fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells. J. Immunol. 147: 1512-1521.
37. Trautmann, L., M. Rimbert, K. Echasserieau, X. Saulquin, B. Neveu, J. Dechanet, V. Cerundolo, and M. Bonneville. 2005. Selection of T cell clones expressing high-affinity public TCRs within human cytomegalovirus-specific CD8 T cell responses. J. Immunol. 175: 6123-6132.
38. Wills, M. R., A. J. Carmichael, K. Mynard, X. Jin, M. P. Weekes, B. Plachter, and J. G. Sissons. 1996. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Virol. 70: 7569-7579.