The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular Iron levels

eLife

Volumn 6, Issue , 2017, Pages

  Miles, Anna L ^a   Burr, Stephen P ^a   Grice, Guinevere L ^a   Nathan, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATASE; CD71 ANTIGEN; FERRITIN; HYPOXIA INDUCIBLE FACTOR 1; IRON; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME; PROTON PUMP; SMALL INTERFERING RNA; TRANSFERRIN RECEPTOR 2; WNT2 PROTEIN; CCDC115 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MEMBRANE PROTEIN; NERVE PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TMEM199 PROTEIN, HUMAN;

ARTICLE; CATALYSIS; CELL FRACTIONATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSFECTION; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROXYLATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IRON DEPLETION; IRON METABOLISM; LYSOSOME; MASS SPECTROMETRY; OXIDATION; PLASMID; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AEROBIC METABOLISM; CELL VACUOLE; ENZYMOLOGY; METABOLISM; PROTEIN PROCESSING;

AEROBIOSIS; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; PROLYL HYDROXYLASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; VACUOLAR PROTON-TRANSLOCATING ATPASES; VACUOLES;

EID: 85017502020     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.22693     Document Type: Article

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