-
1
-
-
84906476318
-
Prodrug objectives and design
-
ADME-Tox Approaches, eds B. Testa and H. van de Waterbeemd, series eds J.B. Taylor and D.J. Triggle), Elsevier, Oxford, UK
-
Testa, B. (2007) Prodrug objectives and design, in ADME-Tox Approaches, Vol. 5 (eds B. Testa and H. van de Waterbeemd), in Comprehensive Medicinal Chemistry II (series eds J.B. Taylor and D.J. Triggle), Elsevier, Oxford, UK, pp. 1009-1041.
-
(2007)
Comprehensive Medicinal Chemistry II
, vol.5
, pp. 1009-1041
-
-
Testa, B.1
-
2
-
-
7444253306
-
Prodrug research: futile or fertile?
-
Testa, B. (2004) Prodrug research: futile or fertile? Biochemical Pharmacology, 68, 2097-2106.
-
(2004)
Biochemical Pharmacology
, vol.68
, pp. 2097-2106
-
-
Testa, B.1
-
3
-
-
2342481809
-
Lessons learned from marketed and investigational prodrugs
-
Ettmayer, P., Amidon, G., Clement, B. and Testa, B. (2004) Lessons learned from marketed and investigational prodrugs. Journal of Medicinal Chemistry, 47, 2393-2404.
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, pp. 2393-2404
-
-
Ettmayer, P.1
Amidon, G.2
Clement, B.3
Testa, B.4
-
5
-
-
0346958512
-
Designofesterprodrugsto enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist
-
Beaumont, K., Webster, R., Gardner, I. and Dack, K. (2003) Designofesterprodrugsto enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist. Current Drug Metabolism, 4, 461-485.
-
(2003)
Current Drug Metabolism
, vol.4
, pp. 461-485
-
-
Beaumont, K.1
Webster, R.2
Gardner, I.3
Dack, K.4
-
6
-
-
2442601735
-
Principles of drug metabolism
-
6th edn (ed. D.J. Abraham), Wiley Interscience, Hoboken, NJ
-
Testa, B. and Soine, W. (2003) Principles of drug metabolism, in Burgefs Medicinal Chemistry and Drug Discovery, Vol. 2, 6th edn (ed. D.J. Abraham), Wiley Interscience, Hoboken, NJ, pp. 431-498.
-
(2003)
Burgefs Medicinal Chemistry and Drug Discovery
, vol.2
, pp. 431-498
-
-
Testa, B.1
Soine, W.2
-
7
-
-
2342582024
-
Concepts in prodrug design to overcome pharmacokinetic problems
-
eds B. Testa, H. van de Waterbeemd, G. Folkers and R. Guy), Wiley-VHCA, Zurich
-
Testa, B. and Mayer, J.M. (2001) Concepts in prodrug design to overcome pharmacokinetic problems, in Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical and Computational Strategies (eds B. Testa, H. van de Waterbeemd, G. Folkers and R. Guy), Wiley-VHCA, Zurich, pp. 85-95.
-
(2001)
Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical and Computational Strategies
, pp. 85-95
-
-
Testa, B.1
Mayer, J.M.2
-
8
-
-
0033006069
-
Prodrug approaches in the improved delivery of peptide drugs
-
Wang, W., Jiang, J., Ballard, C.E. and Wang, B. (1999) Prodrug approaches in the improved delivery of peptide drugs. Current Pharmaceutical Design, 5, 265-287.
-
(1999)
Current Pharmaceutical Design
, vol.5
, pp. 265-287
-
-
Wang, W.1
Jiang, J.2
Ballard, C.E.3
Wang, B.4
-
9
-
-
0001481109
-
Recent advances in prodrugs and antedrugs
-
Lee, H.J., You, Z., Ko, D.H. and McLean, H.M. (1998) Recent advances in prodrugs and antedrugs. Current Opinion in Drug Discovery & Development, 1, 235-244.
-
(1998)
Current Opinion in Drug Discovery & Development
, vol.1
, pp. 235-244
-
-
Lee, H.J.1
You, Z.2
Ko, D.H.3
McLean, H.M.4
-
10
-
-
0343724706
-
Prodrugs for improved CNS delivery
-
Bradley, D.A. (1996) Prodrugs for improved CNS delivery. Advanced Drug Delivery Reviews, 19, 171-202.
-
(1996)
Advanced Drug Delivery Reviews
, vol.19
, pp. 171-202
-
-
Bradley, D.A.1
-
11
-
-
0029865447
-
Prodrugs revisited the "ad hoc" approach as a complement to ligand design
-
Testa, B. and Caldwell, J. (1996) Prodrugs revisited the "ad hoc" approach as a complement to ligand design. Medicinal Research Reviews, 16, 233-241.
-
(1996)
Medicinal Research Reviews
, vol.16
, pp. 233-241
-
-
Testa, B.1
Caldwell, J.2
-
13
-
-
0021800252
-
Prodrugs do they have advantages in clinical practice?
-
Stella, V.J., Charman, W.N.A. and Naringrekar, V.H. (1985) Prodrugs do they have advantages in clinical practice? Drugs, 29, 455-473.
-
(1985)
Drugs
, vol.29
, pp. 455-473
-
-
Stella, V.J.1
Charman, W.N.A.2
Naringrekar, V.H.3
-
14
-
-
0004579318
-
Designing prodrugs and bioprecursors
-
eds G. Jolles and K.R.H. Woolridge), Academic Press, London
-
Wermuth, C.G. (1984) Designing prodrugs and bioprecursors, in Drug Design: Fact or Fantasy? (eds G. Jolles and K.R.H. Woolridge), Academic Press, London, pp. 47-72.
-
(1984)
Drug Design: Fact or Fantasy?
, pp. 47-72
-
-
Wermuth, C.G.1
-
15
-
-
0345712954
-
Drug latentiation
-
eds E. Jucker), Birkhauser, Basel
-
Harper, N.J. (1962) Drug latentiation, in Progress in Drug Research, Vol. 4 (eds E. Jucker), Birkhauser, Basel, pp. 221-294.
-
(1962)
Progress in Drug Research
, vol.4
, pp. 221-294
-
-
Harper, N.J.1
-
16
-
-
0001199533
-
Chemical aspects of selective toxicity
-
Albert, A. (1958) Chemical aspects of selective toxicity. Nature, 182, 421-422.
-
(1958)
Nature
, vol.182
, pp. 421-422
-
-
Albert, A.1
-
17
-
-
0033966357
-
Soft drug design: general principles and recent applications
-
Bodor, N. and Buchwald, P. (2000) Soft drug design: general principles and recent applications. Medicinal Research Reviews, 20, 58-101.
-
(2000)
Medicinal Research Reviews
, vol.20
, pp. 58-101
-
-
Bodor, N.1
Buchwald, P.2
-
18
-
-
0000120844
-
Novel approaches to the design of safer drugs: soft drugs and site specific chemical delivery systems
-
ed. B. Testa), Academic Press, London
-
Bodor, N. (1984) Novel approaches to the design of safer drugs: soft drugs and site specific chemical delivery systems, in Advances in Drug Research, Vol. 13 (ed. B. Testa), Academic Press, London, pp. 255-331.
-
(1984)
Advances in Drug Research
, vol.13
, pp. 255-331
-
-
Bodor, N.1
-
19
-
-
0023277876
-
Esmolol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
-
Benfield, P. and Sorkin, E.M. (1987) Esmolol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs, 33, 392-412.
-
(1987)
Drugs
, vol.33
, pp. 392-412
-
-
Benfield, P.1
Sorkin, E.M.2
-
20
-
-
0041525251
-
Enzyme-mediated precipitation of parent drug from their phosphate prodrugs
-
Heimbach, T., Oh, D.M., Li, L.Y., Rodriguez-Hornedo, N., Garcia, G. and Fleisher, D. (2003) Enzyme-mediated precipitation of parent drug from their phosphate prodrugs. International Journal of Pharmaceutics, 26, 81-92.
-
(2003)
International Journal of Pharmaceutics
, vol.26
, pp. 81-92
-
-
Heimbach, T.1
Oh, D.M.2
Li, L.Y.3
Rodriguez-Hornedo, N.4
Garcia, G.5
Fleisher, D.6
-
21
-
-
0038692005
-
Absorption rate limit considerations for oral phosphate prodrugs
-
Heimbach, T., Oh, D.M., Li, L.Y., Forsberg, M., Savolainen, J., Leppanen, J., Matsunaga, Y., Flynn, G. and Fleisher, D. (2003) Absorption rate limit considerations for oral phosphate prodrugs. Pharmaceutical Research, 20, 848-856.
-
(2003)
Pharmaceutical Research
, vol.20
, pp. 848-856
-
-
Heimbach, T.1
Oh, D.M.2
Li, L.Y.3
Forsberg, M.4
Savolainen, J.5
Leppanen, J.6
Matsunaga, Y.7
Flynn, G.8
Fleisher, D.9
-
22
-
-
0242299572
-
Synthesis, in vitro evaluation, and intraocular pressure effects ofwater-soluble prodrugs ofendocannabinoid noladin ether
-
Juntunen, J., Vepsalainen, J., Niemi, R., Laine, K. and Jarvinen, T. (2003) Synthesis, in vitro evaluation, and intraocular pressure effects ofwater-soluble prodrugs ofendocannabinoid noladin ether. Journal of Medicinal Chemistry, 46, 5083-5086.
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, pp. 5083-5086
-
-
Juntunen, J.1
Vepsalainen, J.2
Niemi, R.3
Laine, K.4
Jarvinen, T.5
-
23
-
-
25844481538
-
In-vitro corneal permeation of cannabinoids and their water-soluble phosphate ester prodrugs
-
Juntunen, J., Jaarvinen, T. and Niemi, R. (2005) In-vitro corneal permeation of cannabinoids and their water-soluble phosphate ester prodrugs. Journal of Pharmacy and Pharmacology, 57, 1153-1157.
-
(2005)
Journal of Pharmacy and Pharmacology
, vol.57
, pp. 1153-1157
-
-
Juntunen, J.1
Jaarvinen, T.2
Niemi, R.3
-
24
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon, G.L., Lennernas, H., Shah, V.P. and Crison, J.R. (1995) A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12, 413-420.
-
(1995)
Pharmaceutical Research
, vol.12
, pp. 413-420
-
-
Amidon, G.L.1
Lennernas, H.2
Shah, V.P.3
Crison, J.R.4
-
25
-
-
0031786423
-
Targeting influenza virus neuraminidase a new strategy for antiviral therapy
-
Oxford, J.S. and Lambkin, R. (1998) Targeting influenza virus neuraminidase a new strategy for antiviral therapy. Drug Discovery Today, 3, 448-456.
-
(1998)
Drug Discovery Today
, vol.3
, pp. 448-456
-
-
Oxford, J.S.1
Lambkin, R.2
-
26
-
-
0034084227
-
Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor
-
Lew, W., Chen, X. and Kim, C.U. (2000) Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor. Current Medicinal Chemistry, 7, 663-672.
-
(2000)
Current Medicinal Chemistry
, vol.7
, pp. 663-672
-
-
Lew, W.1
Chen, X.2
Kim, C.U.3
-
27
-
-
0024166436
-
The design and bioactivation of presystematically stable prodrugs
-
Svensson, L.A. and Tunek, A. (1988) The design and bioactivation of presystematically stable prodrugs. Drug Metabolism Reviews, 19, 165-194.
-
(1988)
Drug Metabolism Reviews
, vol.19
, pp. 165-194
-
-
Svensson, L.A.1
Tunek, A.2
-
28
-
-
0029029678
-
Oral bambuterol versus terbutaline in patients with asthma
-
Persson, G., Pahlm, O. and Gnosspelius, Y. (1995) Oral bambuterol versus terbutaline in patients with asthma. Current Therapeutic Research, 56, 457-465.
-
(1995)
Current Therapeutic Research
, vol.56
, pp. 457-465
-
-
Persson, G.1
Pahlm, O.2
Gnosspelius, Y.3
-
29
-
-
0034807893
-
A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor selective accumulation of 5-FU
-
Tsukamoto, Y., Kato, Y., Ura, M., Horii, I., Ishitsuka, H., Kusuhara, K. and Sugiyama, Y. (2001) A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor selective accumulation of 5-FU. Pharmaceutical Research, 18, 1190-1202.
-
(2001)
Pharmaceutical Research
, vol.18
, pp. 1190-1202
-
-
Tsukamoto, Y.1
Kato, Y.2
Ura, M.3
Horii, I.4
Ishitsuka, H.5
Kusuhara, K.6
Sugiyama, Y.7
-
30
-
-
0036079395
-
Capecitabine: fulfilling the promise of oral chemotherapy
-
Hwang, J.J. and Marshall, J.L. (2002) Capecitabine: fulfilling the promise of oral chemotherapy. Expert Opinion on Pharmacotherapy, 3, 733-743.
-
(2002)
Expert Opinion on Pharmacotherapy
, vol.3
, pp. 733-743
-
-
Hwang, J.J.1
Marshall, J.L.2
-
31
-
-
0033678468
-
Identification and biological activity of the active metabolite of clopidogrel
-
Savi, P., Pereillo, J.M., Uzabiaga, M.F., Combalbert, J., Picard, C., Maffrand, J.P., Pascal, M. and Herbert, J.M. (2000) Identification and biological activity of the active metabolite of clopidogrel. Thrombosis and Haemostasis, 84, 891-896.
-
(2000)
Thrombosis and Haemostasis
, vol.84
, pp. 891-896
-
-
Savi, P.1
Pereillo, J.M.2
Uzabiaga, M.F.3
Combalbert, J.4
Picard, C.5
Maffrand, J.P.6
Pascal, M.7
Herbert, J.M.8
-
33
-
-
0346497703
-
Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine
-
Richter, T., Murdter, T.E., Heinkele, G., Pleiss, J., Tatzel, S., Schwab, M., Eichelbaum, M. and Zanger, U.M. (2004) Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine. Journal of Pharmacology and Experimental Therapeutics, 308, 189-197.
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.308
, pp. 189-197
-
-
Richter, T.1
Murdter, T.E.2
Heinkele, G.3
Pleiss, J.4
Tatzel, S.5
Schwab, M.6
Eichelbaum, M.7
Zanger, U.M.8
-
35
-
-
79953769061
-
Synthetic DNA targeted chemotherapeutic agents and related tumor-activated prodrugs
-
6th edn (ed. D.J. Abraham), Wiley-Interscience, Hoboken, NJ
-
Denny, W.A. (2003) Synthetic DNA targeted chemotherapeutic agents and related tumor-activated prodrugs, in Burger's Medicinal Chemistry and Drug Discovery, Vol. 5, 6th edn (ed. D.J. Abraham), Wiley-Interscience, Hoboken, NJ, pp. 51-105.
-
(2003)
Burger's Medicinal Chemistry and Drug Discovery
, vol.5
, pp. 51-105
-
-
Denny, W.A.1
-
36
-
-
0033180164
-
Receptor-mediated and enzyme dependent targeting of cytotoxic anticancer drugs
-
Dubowchik, G.M. and Walker, M.A. (1999) Receptor-mediated and enzyme dependent targeting of cytotoxic anticancer drugs. Pharmacology & Therapeutics, 83, 67-123.
-
(1999)
Pharmacology & Therapeutics
, vol.83
, pp. 67-123
-
-
Dubowchik, G.M.1
Walker, M.A.2
-
37
-
-
0026502752
-
Enzymology ofthe reduction ofthe potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR4233 (WIN 59075) by NAD(P) H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells
-
Riley, R.J. and Workman, P. (1992) Enzymology ofthe reduction ofthe potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR4233 (WIN 59075) by NAD(P) H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells. Biochemical Pharmacology, 43, 167-174.
-
(1992)
Biochemical Pharmacology
, vol.43
, pp. 167-174
-
-
Riley, R.J.1
Workman, P.2
-
38
-
-
0037460188
-
Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction
-
Anderson, R.F., Shinde, S.S., Hay, M.P., Gamage, S.A. and Denny, W.A. (2003) Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction. Journal ofthe American Chemical Society, 125, 748-756.
-
(2003)
Journal ofthe American Chemical Society
, vol.125
, pp. 748-756
-
-
Anderson, R.F.1
Shinde, S.S.2
Hay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
39
-
-
84906432412
-
Drug-polymer conjugates
-
ADME-Tox Approaches, eds B. Testa and H. van de Waterbeemd, series eds J.B. Taylor and D.J. Triggle), Elsevier, Oxford, UK
-
Veronese, F.M. and Pasut, G. (2007) Drug-polymer conjugates, in ADME-Tox Approaches, Vol. 5 (eds B. Testa and H. van de Waterbeemd), in Comprehensive Medicinal Chemistry II (series eds J.B. Taylor and D.J. Triggle), Elsevier, Oxford, UK, pp. 1043-1068.
-
(2007)
Comprehensive Medicinal Chemistry II
, vol.5
, pp. 1043-1068
-
-
Veronese, F.M.1
Pasut, G.2
-
40
-
-
0033502650
-
Prodrugs for antibody and gene-directed enzyme prodrug therapies (ADEPTand GDEPT)
-
Niculescu-Duvaz, I., Friedlos, F., Niculescu-Duvaz, D., Davies, L. and Springer, C.J. (1999) Prodrugs for antibody and gene-directed enzyme prodrug therapies (ADEPTand GDEPT). Anti-Cancer Drug Design, 14, 517-538.
-
(1999)
Anti-Cancer Drug Design
, vol.14
, pp. 517-538
-
-
Niculescu-Duvaz, I.1
Friedlos, F.2
Niculescu-Duvaz, D.3
Davies, L.4
Springer, C.J.5
-
41
-
-
0034511833
-
Polymer-directed enzyme prodrug therapy
-
Cassidy, J. (2000) Polymer-directed enzyme prodrug therapy. Drug News & Perspectives, 13, 477-480.
-
(2000)
Drug News & Perspectives
, vol.13
, pp. 477-480
-
-
Cassidy, J.1
-
43
-
-
0141839804
-
Selective activation of anthracycline prodrugs for use in conjunction with ADEPT
-
HariKrishna, D. Raghu Ram Rao, A. and Krishna, D.R. (2003) Selective activation of anthracycline prodrugs for use in conjunction with ADEPT. Drug News & Perspectives, 16, 309-318.
-
(2003)
Drug News & Perspectives
, vol.16
, pp. 309-318
-
-
HariKrishna, D.1
Raghu Ram Rao, A.2
Krishna, D.R.3
-
44
-
-
23444457117
-
Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy
-
Davies, L.C., Friedlos, F., Hedley, D., Martin, J., Ogilvie, L.M., Scanlon, I.J. and Springer, C.J. (2005) Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy. Journal ofMedicinal Chemistry, 48, 5321-5328.
-
(2005)
Journal ofMedicinal Chemistry
, vol.48
, pp. 5321-5328
-
-
Davies, L.C.1
Friedlos, F.2
Hedley, D.3
Martin, J.4
Ogilvie, L.M.5
Scanlon, I.J.6
Springer, C.J.7
-
45
-
-
0031726953
-
Design of intramolecularly activated prodrugs
-
Testa, B. and Mayer, J.M. (1998) Design of intramolecularly activated prodrugs. Drug Metabolism Reviews, 30, 787-807.
-
(1998)
Drug Metabolism Reviews
, vol.30
, pp. 787-807
-
-
Testa, B.1
Mayer, J.M.2
|