Frontline science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/∆7 mice

Journal of Leukocyte Biology

Volumn 101, Issue 4, 2017, Pages 811-821

  van Beek, Adriaan A ^a,c,d   Hugenholtz, Floor ^c,d   Meijer, Ben ^d   Sovran, Bruno ^b,c,d   Perdijk, Olaf ^d   Vermeij, Wilbert P ^a   Brandt, Renata M C ^a   Barnhoorn, Sander ^a   Hoeijmakers, Jan H J ^a   de Vos, Paul ^c,e   Leenen, Pieter J M ^a   Hendriks, Rudi W ^a   Savelkoul, Huub F J ^d  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UMR1319 MICALIS   (France)

^c TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Bone marrow; Gut microbiota; Hematopoiesis; Proliferation

Indexed keywords

TRYPTOPHAN; DNA BINDING PROTEIN; ENDONUCLEASE; ERCC1 PROTEIN, MOUSE;

AKKERMANSIA; ALISTIPES; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; IMMUNOLOGICAL TOLERANCE; INTESTINE FLORA; MEMORY T LYMPHOCYTE; MICROBIAL DIVERSITY; MOUSE; NONHUMAN; PRE T LYMPHOCYTE; PREMATURE AGING; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN; T LYMPHOCYTE; TRYPTOPHAN METABOLISM; WILD TYPE MOUSE; ANIMAL; BACTERIUM; BONE MARROW; C57BL MOUSE; CYTOLOGY; DIET; GASTROINTESTINAL TRACT; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE COUNT; METABOLISM; MICROBIOLOGY; MICROFLORA;

AGING, PREMATURE; ANIMALS; B-LYMPHOCYTES; BACTERIA; BONE MARROW; DIET; DNA-BINDING PROTEINS; ENDONUCLEASES; FEMALE; GASTROINTESTINAL TRACT; IMMUNOLOGIC MEMORY; LYMPH NODES; LYMPHOCYTE COUNT; MICE, INBRED C57BL; MICROBIOTA; SPLEEN; T-LYMPHOCYTES, REGULATORY; TRYPTOPHAN;

EID: 85017318928     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.1HI0216-062RR     Document Type: Article

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