Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses

Biomaterials

Volumn 132, Issue , 2017, Pages 48-58

  Rincon Restrepo, Marcela ^a   Mayer, Aaron ^a   Hauert, Sylvie ^a   Bonner, Daniel K ^a   Phelps, Edward A ^a   Hubbell, Jeffrey A ^a,b   Swartz, Melody A ^a,b   Hirosue, Sachiko ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Antigen presentation; Dendritic cells; Germinal center; T follicular helper cells; Vaccine design

Indexed keywords

ANTIBODIES; ANTIGENS; CELLS; CELLULAR MANUFACTURING; CHEMICAL ACTIVATION; CYTOLOGY; ENZYME ACTIVITY; IMMUNE SYSTEM; NANOPARTICLES; SILVER; VACCINES;

ADAPTIVE IMMUNE RESPONSE; ANTIGEN PRESENTATION; DENDRITIC CELLS; GERMINAL CENTERS; INTRACELLULAR PATHWAYS; INTRACELLULAR TRAFFICKING; NANOPARTICULATE SYSTEM; VACCINE DEVELOPMENT;

T-CELLS;

ANTIGEN; COPOLYMER; NANOCARRIER; OVALBUMIN; POLYMER; POLYMERSOME; UNCLASSIFIED DRUG; VACCINE; NANOCAPSULE; NANOCOMPOSITE; SILVER;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANTIBODY TITER; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; FEMALE; GERMINAL CENTER; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; LYMPH NODE; MOUSE; NANOENCAPSULATION; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; SPLEEN; SYNTHESIS; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CHEMISTRY; CHICK EMBRYO; CYTOPLASM; DENDRITIC CELL; DRUG DELIVERY SYSTEM; HELPER CELL; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; TISSUE DISTRIBUTION;

ANIMALS; ANTIGENS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHICK EMBRYO; CYTOPLASM; DENDRITIC CELLS; DRUG DELIVERY SYSTEMS; FEMALE; GERMINAL CENTER; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; NANOCAPSULES; NANOCOMPOSITES; OVALBUMIN; POLYMERS; SILVER; T-LYMPHOCYTES, HELPER-INDUCER; TISSUE DISTRIBUTION; VACCINES;

EID: 85017265122     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2017.03.047     Document Type: Article

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