Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 50, 2005, Pages 17987-17992

  Austin, Cary D ^a   Wen, Xiaohui ^a   Gazzard, Lewis ^a   Nelson, Christopher ^a   Scheller, Richard H ^a   Scales, Suzie J ^a  

^a GENENTECH INC   (United States)

Author keywords

Disulfide linker; Endocytosis; HER2; Herceptin; Redox potential

Indexed keywords

ANTIBODY CONJUGATE; DISULFIDE; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; GREEN FLUORESCENT PROTEIN; N SUCCINIMIDYL 4 (2 PYRIDYLDITHIO)PENTANOATE; RHODAMINE; TRASTUZUMAB; TRASTUZUMAB N SUCCINIMIDYL 4 (2 PYRIDYLDITHIO)PENTANOATE RHODAMINE RED CONJUGATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOCYTOSIS; ENDOSOME; FLUORESCENCE; HUMAN; HUMAN CELL; LYSOSOME; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; BENZOQUINONES; CELL LINE, TUMOR; DISULFIDES; ENDOSOMES; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOCONJUGATES; LACTAMS, MACROCYCLIC; LYSOSOMES; MICROSCOPY, FLUORESCENCE; OXIDATION-REDUCTION; QUINONES; RHODAMINES; SPECTROMETRY, FLUORESCENCE;

EID: 29144496897     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509035102     Document Type: Article

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