A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation

Nature Medicine

Volumn 23, Issue 5, 2017, Pages 611-622

  Fujiu, Katsuhito ^a,b   Shibata, Munehiko ^a   Nakayama, Yukiteru ^a   Ogata, Fusa ^a   Matsumoto, Sahohime ^a   Noshita, Koji ^c   Iwami, Shingo ^b,d   Nakae, Susumu ^a,b   Komuro, Issei ^a   Nagai, Ryozo ^e   Manabe, Ichiro ^f  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e JICHI MEDICAL UNIVERSITY   (Japan)

^f CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; BETA 2 ADRENERGIC RECEPTOR; CD11B ANTIGEN; COLONY STIMULATING FACTOR; CRE RECOMBINASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; KRUPPEL LIKE FACTOR 5; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; ADRB1 PROTEIN, MOUSE; AREG PROTEIN, MOUSE; ARGIPRESSIN; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALGRANULIN A; CALGRANULIN B; KLF5 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; NORADRENALIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC CONSTRICTION; ARTICLE; CARDIAC MUSCLE; CELL INTERACTION; CELL POPULATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; GENOTYPE; GRANULOCYTE; HEART FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART STRESS; HEART VENTRICLE HYPERTROPHY; KIDNEY COLLECTING TUBULE; KIDNEY FUNCTION; KIDNEY TUBULE CELL; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ADAPTATION; ANIMAL; AORTA; BONE MARROW TRANSPLANTATION; BRAIN; CYTOLOGY; ECHOCARDIOGRAPHY; FLOW CYTOMETRY; GENE SILENCING; GENETICS; GLOMERULUS FILTRATION RATE; HEART; HEART FAILURE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INNERVATION; KIDNEY; KIDNEY ARTERY; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SURGERY; SYMPATHECTOMY; URINE; WESTERN BLOTTING;

ADAPTATION, PHYSIOLOGICAL; ADRENERGIC BETA-ANTAGONISTS; AMPHIREGULIN; ANIMALS; AORTA; ARGININE VASOPRESSIN; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; BRAIN; CALGRANULIN A; CALGRANULIN B; ECHOCARDIOGRAPHY; ENDOTHELIAL CELLS; FLOW CYTOMETRY; GENE KNOCKDOWN TECHNIQUES; GLOMERULAR FILTRATION RATE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEART; HEART FAILURE; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TUBULES, COLLECTING; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MACROPHAGES; MICE; MICE, KNOCKOUT; MYOCARDIUM; NOREPINEPHRINE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RENAL ARTERY; STRESS, PHYSIOLOGICAL; SYMPATHECTOMY; SYMPATHETIC NERVOUS SYSTEM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85017226414     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4326     Document Type: Article

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