Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: A prospective study

Circulation

Volumn 123, Issue 4, 2011, Pages 381-390

  Birks, Emma J ^a,b,c   George, Robert S ^a,b   Hedger, Mike ^a   Bahrami, Toufan ^a,b   Wilton, Penny ^a   Bowles, Christopher T ^a   Webb, Carole ^a   Bougard, Robert ^a   Amrani, Mohammed ^a   Yacoub, Magdi H ^a,b   Dreyfus, Gilles ^a   Khaghani, Asghar ^a  

^a ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

cardiac transplantation; cardiomyopathy; heart failure; heart assist device

Indexed keywords

BILIRUBIN; BISOPROLOL; CARVEDILOL; CLENBUTEROL; CREATININE; DIGOXIN; LEVITRONIX; LISINOPRIL; LOSARTAN; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AORTA BALLOON; ARTICLE; ASSISTED VENTILATION; BILIRUBIN BLOOD LEVEL; CARDIAC PATIENT; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONVALESCENCE; CORONARY ARTERY BLOOD FLOW; CREATININE BLOOD LEVEL; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; EXERCISE TEST; EXPLANT; EXTRACORPOREAL OXYGENATION; FEMALE; FOLLOW UP; HEART ASSIST DEVICE; HEART CATHETERIZATION; HEART EJECTION FRACTION; HEART FAILURE; HEART INDEX; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART RATE; HEMOFILTRATION; HUMAN; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULMONARY ARTERY OCCLUSION PRESSURE; RECURRENT DISEASE; SURVIVAL TIME;

ADULT; CARDIOMYOPATHY, DILATED; CARDIOVASCULAR AGENTS; CLENBUTEROL; FEMALE; HEART FAILURE; HEART-ASSIST DEVICES; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STROKE VOLUME; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT; YOUNG ADULT;

EID: 79751533489     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.933960     Document Type: Article

References (18)

1. Miller LW, Pagani FD, Russell SD, John R, Boyle A, Aaronson KD, Conte JV, Naka Y, Mancini D, Delgado RM, MacGillivray TE, Farrar DJ, Frazier OHl. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357:885-896. (Pubitemid 47347322)
2. Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, Sun B, Tatooles AJ, Delgado RM III, Long JW, Wozniak TC, Ghumman W, Farrar DJ, Frazier OH; the HeartMate II Investigators. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009:361:2241-2251.
3. Frazier OH, Radovancevic B, Abou-Awdi NL, Wilansky S, Jin B, Capek P, Mac Allister HA, Seifein H, Macris MP. Ventricular remodelling after prolonged ventricular unloading "heart rest" experience with the Heartmate left ventricular assist device. J Heart Lung Transplant 1994; 13:77. Abstract.
4. Frazier OH, Myers TJ. Left ventricular assist system as a bridge to myocardial recovery. Ann Thorac Surg. 1999;68:734-741. (Pubitemid 29527024)
5. Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J, Winowich S, McNamara DM. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation. 2005;112(suppl):I-32-I-36. (Pubitemid 41266650)
6. Dandel M, Weng Y, Siniawski H, Potapov E, Drews T, Lehmkuhl HB, Knosalla C, Hetzer R. Prediction of cardiac stability after weaning from left ventricular assist devices in patients with idiopathic dilated cardiomyopathy. Circulation. 2008;118(suppl):S94-S105.
7. Mancini DM, Beniaminovitz A, Levin H, Cantanese K, Flannery M, Di Tullio M, Savin S, Cordisco ME, Rose E, Oz M. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation. 1998;98:2383-2389. (Pubitemid 28549781)
8. Maybaum S, Mancini D, Xydas S, Starling RC, Aaronson K, Pagani FD, Miller LW, Margulies K, McRee S, Frazier OH, Torre-Amione G. Cardiac improvement during mechanical circulatory support a prospective multicentre study of the LVAD Working Group. Circulation. 2007;115:2497-2505. (Pubitemid 46763223)
9. Yacoub MH, Tansley P, Birks EJ, Bowles CT, Banner NR, Khaghani A. A novel combination therapy to reverse end-stage heart failure. Transplant Proc. 2001;33:2762-2764. (Pubitemid 32725882)
10. Birks EJ, Tansley PD, Hardy J, George R, Bowles CT, Burke M, Banner NR, Khaghani A, Yacoub MH. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med. 2006;355:1873-1884. (Pubitemid 44664645)
11. Wong K, Boheler KR, Bishop J, Petrou M, Yacoub MH. Clenbuterol induces cardiac hypertrophy with normal functional, morphological and molecular features. Cardiovasc Res. 1998;37:115-122. (Pubitemid 28122623)
12. Wong K, Boheler KR, Petrou M, Yacoub MH. Pharmacological modulation pressure overload cardiac hypertrophy changes in ventricular function, extracellular matrix, and gene expression. Circulation. 1997;96: 2239-2246.
13. Soppa GKR, Smolenski RT, Latif N, Yuen A, Malik A, Karbowska JK, Kochan Z, Terracciano, Yacoub MH. Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle. Am J Physiol Heart Circ Physiol. 2005;288:H1468-H1476. (Pubitemid 40270059)
14. George RS, Yacoub MH, Bowles CT, Hipkin M, Rogers P, Hallas C, Banner NR, Dreyfus G, Khaghani A, Birks EJ. Quality of life after removal of left ventricular assist device for myocardial recovery. J Heart Lung Transplant. 2008;27:165-172. (Pubitemid 351221041)
15. Haj-Yahia S, Birks EJ, Dreyfus G, Khaghani A. Limited surgical approach for explanting the HeartMate II left ventricular assist device after myocardial recovery. J Thorac Cardiovasc Surg. 2008;135: 453-454. (Pubitemid 351181314)
16. Komoda T, Komoda S, Dandel M, Weng Y, Hetzer R. Explantation of INCOR left ventricular assist device after myocardial recovery. J Card Surg. 2008;23:642-647.
17. George RS, Yacoub MH, Tasca G, Webb C, Bowles CT, Tansley P, Hardy JP, Dreyfus G, Khaghani A, Birks EJ. Haemodynamic and echocardiographic responses to acute interruption of left ventricular assist device support- relevance to assessment of myocardial recovery. J Heart Lung Transplant. 2007;26:967-973. (Pubitemid 47500147)
18. George RS, Sabharwal NK, Webb C, Yacoub MH, Bowles CT, Hedger M, Khaghani A, Birks EJ. Echocardiographic assessment of flow across continuous-flow ventricular assist devices at low speeds. J Heart Lung Transplant. 2010;29:1245-1252.