A high throughput dried DMSO Log D lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection

Journal of Chromatography A

Volumn 1217, Issue 12, 2010, Pages 1950-1955

  Alelyunas, Yun W ^a   Pelosi Kilby, Luciana ^a   Turcotte, Pascal ^a   Kary, Mary Britt ^a   Spreen, Russell C ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

APPI MS; Automation; LC MS; LC UV; Lipophilicity; Log D; Physical properties

Indexed keywords

96-WELL; ATMOSPHERIC PRESSURE PHOTO IONIZATION; COEFFICIENT OF DETERMINATION; COSOLVENT EFFECTS; HIGH THROUGHPUT; LC/MS; LIPOPHILICITY; LIPOPHILICITY MEASUREMENT; LIQUID HANDLING; LIQUID STORAGE; REVERSED-PHASE COLUMNS; SAMPLE PREPARATION; SOLID-LIKE MATERIALS; STATE OF THE ART; ULTRAHIGH PRESSURE;

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; AUTOMATION; DIMETHYL SULFOXIDE; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PARTICLE DETECTORS; PHYSICAL PROPERTIES;

IONIZATION OF LIQUIDS;

ACEBUTOLOL; ALBENDAZOLE; ALPRENOLOL; AMIODARONE; ASTEMIZOLE; ATENOLOL; ATROPINE; BUPIVACAINE; CARBAMAZEPINE; CHLORPHENIRAMINE; CHLORTALIDONE; CLOZAPINE; DIMETHYL SULFOXIDE; FLECAINIDE; FLURBIPROFEN; GRISEOFULVIN; HYDROCORTISONE; IBUPROFEN; IMIPRAMINE; KETOCONAZOLE; LABETALOL; LIDOCAINE; LORATADINE; METRONIDAZOLE; MEXILETINE; OCTANOL; OXPRENOLOL; PREDNISOLONE; UNINDEXED DRUG; WATER;

ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; LIPOPHILICITY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STORAGE; VALIDITY;

ATMOSPHERIC PRESSURE; BUFFERS; CHROMATOGRAPHY, LIQUID; DIMETHYL SULFOXIDE; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN-ION CONCENTRATION; IONS; MASS SPECTROMETRY; MODELS, CHEMICAL; OCTANOLS; REPRODUCIBILITY OF RESULTS; ULTRAVIOLET RAYS;

EID: 76949100912     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.01.071     Document Type: Article

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