Acute dark chocolate ingestion is beneficial for hemodynamics via enhancement of erythrocyte deformability in healthy humans

Nutrition Research

Volumn 39, Issue , 2017, Pages 69-75

  Radosinska, Jana ^a,b   Horvathova, Martina ^a   Frimmel, Karel ^b   Muchova, Jana ^a   Vidosovicova, Maria ^a   Vazan, Rastislav ^a   Bernatova, Iveta ^b  

^a Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Chocolate; Erythrocyte deformability; Erythrocytes; Nitric oxide; Trolox equivalence antioxidant capacity assay

Indexed keywords

NITRIC OXIDE; ANTIOXIDANT; PLANT MEDICINAL PRODUCT; POLYPHENOL;

ADULT; ANTIOXIDANT ASSAY; ARTICLE; CHOCOLATE; DARK CHOCOLATE; ERYTHROCYTE DEFORMABILITY; FEMALE; FOOD INTAKE; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; MALE; MILK; NORMAL HUMAN; PLASMA; TISSUE OXYGENATION; ANIMAL; BLOOD; CACAO; CHEMISTRY; CONTROLLED STUDY; DIET; DRUG EFFECTS; EATING; ERYTHROCYTE; METABOLISM; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; YOUNG ADULT;

ADULT; ANIMALS; ANTIOXIDANTS; CACAO; CHOCOLATE; DIET; EATING; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTES; FEMALE; HEMODYNAMICS; HUMANS; MALE; MILK; NITRIC OXIDE; PLANT PREPARATIONS; POLYPHENOLS; REFERENCE VALUES; YOUNG ADULT;

EID: 85017027316     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2017.03.002     Document Type: Article

References (26)

1. [1] Andújar, I., Recio, M.C., Giner, R.M., Ríos, J.L., Cocoa polyphenols and their potential benefits for human health. Oxid Med Cell Longev, 2012, 2012, 906252, 10.1155/2012/906252.
2. [2] Aggio, A., Grassi, D., Onori, E., D'Alessandro, A., Masedu, F., Valenti, M., et al. Endothelium/nitric oxide mechanism mediates vasorelaxation and counteracts vasoconstriction induced by low concentration of flavanols. Eur J Nutr 52 (2013), 263–272, 10.1007/s00394-012-0320-x.
3. [3] Radosinska, J., Vrbjar, N., The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia. Physiol Res 65 (2016), S43–S54.
4. [4] Heiss, C., Sansone, R., Karimi, H., Krabbe, M., Schuler, D., Rodriguez-Mateos, A., et al. Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordr), 37, 2015, 9794.
5. [5] Kluknavsky, M., Balis, P., Puzserova, A., Radosinska, J., Berenyiova, A., Drobna, M., et al. (−)-Epicatechin prevents blood pressure increase and reduces locomotor hyperactivity in young spontaneously hypertensive rats. Oxid Med Cell Longev, 2016, 10.1155/2016/6949020.
6. [6] Radosinska, J., Mezesova, L., Okruhlicova, L., Frimmel, K., Breierova, E., Bartekova, M., et al. Effect of yeast biomass with high content of carotenoids on erythrocyte deformability, NO production and Na,K-ATPase activity in healthy and LPS treated rats. Clin Hemorheol Microcirc 64 (2016), 125–134, 10.3233/CH-162051.
7. [7] Cortese-Krott, M.M., Rodriguez-Mateos, A., Sansone, R., Kuhnle, G.G., Thasian-Sivarajah, S., Krenz, T., et al. Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood 120 (2012), 4229–4237, 10.1182/blood-2012-07-442277.
8. [8] Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice–Evans, C., Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26 (1999), 1231–1237.
9. [9] Schroeter, H., Heiss, C., Balzer, J., Kleinbongard, P., Keen, C.L., Hollenberg, N.K., et al. (−)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103 (2006), 1024–1029.
10. [10] Dower, J.I., Geleijnse, J.M., Kroon, P.A., Philo, M., Mensink, M., Kromhout, D., et al. Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomised, crossover study. Mol Nutr Food Res, 2016, 10.1002/mnfr.201600045.
11. [11] Holt, R.R., Lazarus, S.A., Sullards, M.C., Zhu, Q.Y., Schramm, D.D., Hammerstone, J.F., et al. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr 76 (2002), 798–804.
12. [12] Rein, D., Lotito, S., Holt, R.R., Keen, C.L., Schmitz, H.H., Fraga, C.G., Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status. J Nutr 130 (2000), 2109S–2114S.
13. [13] Serafini, M., Bugianesi, R., Maiani, G., Valtuena, S., De Santis, S., Crozier, A., Plasma antioxidants from chocolate. Nature, 424, 2003, 1013.
14. [14] Carnevale, R., Loffredo, L., Pignatelli, P., Nocella, C., Bartimoccia, S., Di Santo, S., et al. Dark chocolate inhibits platelet isoprostanes via NOX2 down-regulation in smokers. J Thromb Haemost 10 (2012), 125–132, 10.1111/j.1538-7836.2011.04558.x.
15. [15] Schmid-Schönbein, H., Microrheology of erythrocytes, blood viscosity, and the distribution of blood flow in the microcirculation. Int Rev Physiol 9 (1976), 1–62.
16. [16] Lamport, D.J., Pal, D., Moutsiana, C., Field, D.T., Williams, C.M., Spencer, J.P., et al. The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial. Psychopharmacology (Berl) 232 (2015), 3227–3234.
17. [17] Sorond, F.A., Hollenberg, N.K., Panych, L.P., Fisher, N.D., Brain blood flow and velocity: correlations between magnetic resonance imaging and transcranial Doppler sonography. J Ultrasound Med 29 (2010), 1017–1022.
18. [18] Shiina, Y., Funabashi, N., Lee, K., Murayama, T., Nakamura, K., Wakatsuki, Y., et al. Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults. Int J Cardiol 131 (2009), 424–429.
19. [19] Neukam, K., Stahl, W., Tronnier, H., Sies, H., Heinrich, U., Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. Eur J Nutr 46 (2007), 53–56.
20. [20] Mohanty, J.G., Nagababu, E., Rifkind, J.M., Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging. Front Physiol, 5, 2014, 84.
21. [21] Lettieri-Barbato, D., Tomei, F., Sancini, A., Morabito, G., Serafini, M., Effect of plant foods and beverages on plasma non-enzymatic antioxidant capacity in human subjects: a meta-analysis. Br J Nutr 109 (2013), 1544–1556.
22. [22] Scheid, L., Reusch, A., Stehle, P., Ellinger, S., Antioxidant effects of cocoa and cocoa products ex vivo and in vivo: is there evidence from controlled intervention studies?. Curr Opin Clin Nutr Metab Care 13 (2010), 737–742.
23. [23] Khoory, J., Estanislau, J., Elkhal, A., Lazaar, A., Melhorn, M.I., Brodsky, A., et al. Ligation of glycophorin a generates reactive oxygen species leading to decreased red blood cell function. PLoS One, 11, 2016, e0141206, 10.1371/journal.pone.0141206.
24. [24] Loffredo, L., Perri, L., Catasca, E., Pignatelli, P., Brancorsini, M., Nocella, C., et al. Dark chocolate acutely improves walking autonomy in patients with peripheral artery disease. J Am Heart Assoc, 3, 2014, e001072, 10.1161/JAHA.114.001072.
25. [25] Kleinbongard, P., Keymel, S., Kelm, M., New functional aspects of the L-arginine-nitric oxide metabolism within the circulating blood. Thromb Haemost 98 (2007), 970–974.
26. [26] Bor-Kucukatay, M., Wenby, R.B., Meiselman, H.J., Baskurt, O.K., Effects of nitric oxide on red blood cell deformability. Am J Physiol Heart Circ Physiol 284 (2003), H1577–H1584.