Endothelium/nitric oxide mechanism mediates vasorelaxation and counteracts vasoconstriction induced by low concentration of flavanols

European Journal of Nutrition

Volumn 52, Issue 1, 2013, Pages 263-272

  Aggio, Annalisa ^a   Grassi, Davide ^a   Onori, Eugenia ^a   D'Alessandro, Antonio ^a   Masedu, Francesco ^a   Valenti, Marco ^a   Ferri, Claudio ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Endothelium; Flavanols; Flavonoids; Nitric oxide; Vasorelaxation

Indexed keywords

EPICATECHIN; EPIGALLOCATECHIN GALLATE; N(G) NITROARGININE; NITRIC OXIDE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTERY TONE; ARTICLE; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; NONHUMAN; RAT; REGULATORY MECHANISM; REST; VASOCONSTRICTION; VASODILATATION;

ANIMALS; AORTA, THORACIC; CATECHIN; ENDOTHELIUM, VASCULAR; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTION; VASODILATION; VASODILATOR AGENTS;

RATTUS;

EID: 84872682152     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0320-x     Document Type: Article

References (39)

1. Vita JA (2003) Tea consumption and cardiovascular disease: effects on endothelial function. J Nutr 133:3293S-3297S (Pubitemid 37222258)
2. Kuriyama S, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ebihara S, Awata S, Nagatomi R, Arai H, Tsuji I (2006) Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan. Am J Clin Nutr 83:355-361
3. Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney JF Jr, Vita JA (2007) Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr 2:95-102 (Pubitemid 46911252)
4. Duffy SJ, Keaney JF Jr, Holbrook M, Gokce N, Swerdloff PL, Frei B, Vita JA (2001) Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 104:151-156 (Pubitemid 32655830)
5. Schroeter H, Heiss C, Balzer J et al (2006) (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS 103:1024-1029 (Pubitemid 43212215)
6. Engler MB, Engler MM, Chen CY, Malloy MJ, Browne A, Chiu EY, Kwak HK, Milbury P, Paul SM, Blumberg J, Mietus-Snyder ML (2004) Flavanoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr 23:197-204 (Pubitemid 38746107)
7. + channel activations. Biosci Biochem Biotechnol 73:2246-2251
8. Grassi D, Lippi C, Necozione S, Desideri G, Ferri C (2005) Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 81:611-614
9. Grassi D, Desideri G, Necozione S, Lippi C, Casale R, Properzi G, Blumberg JB, Ferri C (2008) Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr 138:1671-1676
10. Corretti MC, Anderson TJ, Benjamin EJ et al (2002) International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 16:257-265 (Pubitemid 34084631)
11. Rice-Evans CA, Miller NJ, Paganga G (1996) Structure-antioxidant activity relationships of flavanoids and phenolic acids. Free Radic Biol Med 20:933-956 (Pubitemid 26157509)
12. Richelle M, Tavazzi I, Enslen M, Offord EA (1999) Plasma kinetics in man of epicatechin from black chocolate. Eur J Clin Nutr 53:22-26 (Pubitemid 29041818)
13. Auger C, Kim JH, Chabert P, Chaabi M, Anselm E, Lanciaux X, Lobstein A, Schini-Kerth VB (2010) The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties. Biochem Biophys Res Commun 393:162-167
14. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F (2010) (-)-Epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension 55:1398-1405
15. Moore RJ, Jackson KG, Minihane AM (2009) Green tea (Camellia sinensis) catechins and vascular function. Br J Nutr 102:1790-1802
16. Duarte J, Vizcaino P, Zarzuelo A, Jimenez J, Tamargo J (1993) Vasodilatator effects of quercetin in isolated rat vascular smooth muscle. Eur J Pharmacol 239:1-7 (Pubitemid 23240133)
17. Herrera MD, Zarzuelo A, Jimenez J, Marhuenda E, Duarte J (1996) Effects of flavonoids on rat aortic smooth muscle contractility: structure-activity relationships. Gen Pharmac 27:273-277 (Pubitemid 26129187)
18. Chan ECH, Pannangpetch P, Woodman OL (2000) Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. J Cardiovasc Pharmacol 35:326-333 (Pubitemid 30073828)
19. Woodman OL, Meeker WF, Boujaoude M (2005) Vasorelaxant and antioxidant activity of flavanols and flavones: structure-activity relationships. J Cardiovasc Pharmacol 46:302-309 (Pubitemid 41262832)
20. Sanae F, Miyaichi Y, Kizu H, Hayashi H (2002) Effect of catechins on vascular tone in rat aortic thoracic aorta with endothelium. Life Sci 71:2553-2562 (Pubitemid 35247961)
21. Lorenz M, Wessler S, Follmann E et al (2004) A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 279:6190-6195 (Pubitemid 38220652)
22. Lorenz M, Urban J, Engelhardt U, Baumann G, Stangl K, Stangl V (2009) Green and black tea are equally potent stimuli of NO production and vasodilation: new insights into tea ingredients involved. Basic Res Cardiol 104:100-110
23. Lim DY, Lee ES, Park HG, Kim BC, Hong SP, Lee EB (2003) Comparison of green tea extract and epigallocatechin gallate on blood pressure and contractile responses of vascular smooth muscle of rats. Arch Pharm Res 26:214-223
24. Angus JA, Wrigth CE (2000) Techniques to study the pharmacodynamics of isolated large and small blood vessel. J Pharmacol Toxicol Methods 44:395-407 (Pubitemid 32452202)
25. Nishimura K, Ota M, Ito K (1991) Existence of two components in the tonic contraction of rat aorta mediated by α1-adrenoceptor activation. Br J Pharmacol 102:215-221
26. Ajay M, Gilani AH, Mustafa MR (2003) Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci 74:603-612 (Pubitemid 37410351)
27. 2-mediated multiple-signalling pathways. Clin Exp Pharmacol Physiol 30:88-95 (Pubitemid 36232750)
28. Schrammel A, Behrends S, Schmidt K, Koesling D, Mayer B (1996) Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol 50:1-6
29. Alvarez-Castro E, Campos-Tomoil M, Orallo F (2004) (-)-Epigallocatechin- 3-gallate induces contraction of the rat aorta by a calcium influx-dependent mechanism. Naunyn-Schmiedeberg's Arch Pharmacol 369:496-506 (Pubitemid 38669969)
30. Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD (2008) Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr 88:1018-1025
31. Huang Y, Chan NW, Lau CW, Yao XQ, Chan FL, Chen ZY (1999) Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin. Biochim Biophys Acta 1427:322-328 (Pubitemid 29182784)
32. Kim JA, Formoso G, Li Y, Potenza MA, Marasciulo FL, Montagnani M, Quon MJ (2007) Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem 282:13736-13745 (Pubitemid 47100559)
33. Alvarez E, Campos-Toimil M, Justiniani-Basaran H, Lugnier C, Orallo F (2006) Study the of the mechanisms involved in the vasorelaxation induced by (-)- epigallocatechin-3-gallate in rat aorta. Br J Pharmacol 147:269-280 (Pubitemid 43214684)
34. Chen ZY, Law WI, Yao XQ, Lau CW, Ho WK, Huang Y (2000) Inhibitory effects of purified green tea epicatechins on contraction and proliferation of arterial smooth muscle cells. Acta Pharmacol Sin 21:835-840
35. Martin W, Furchgott RF, Villani GM, Jothianandan D (1986) Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor. J Pharmacol Exp Ther 237:529-538 (Pubitemid 16092813)
36. Chen ZY, Su YL, Lau WI, Huang Y (1999) Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery. Euro J Pharmacol 374:41-47 (Pubitemid 29296724)
37. Wyse GD (1990) On the "normalization" of active developed force of isolated helical strips of muscular and elastic arteries for variation in wall thickness. J Pharmacol Methods 4:313-326
38. Li Z, Wang Y, Vanhoutte PM (2011) Epigallocatechin Gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat. Basic Clin Pharmacol Toxicol 109(1):47-55
39. Gendron ME, Théorêt JF, Mamarbachi AM et al (2010) Late chronic catechin antioxidant treatment is deleterious to the endothelial function in aging mice with established atherosclerosis. Am J Physiol Heart Circ Physiol 298(6):H2062-H2070