Micelle-based adjuvants for subunit vaccine delivery

Vaccines

Volumn 3, Issue 4, 2015, Pages 803-813

  Trimaille, Thomas ^a   Verrier, Bernard ^b  

^a AIX MARSEILLE UNIV   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Amphiphilic copolymers; Antigens; Micelles; Peptide amphiphiles

Indexed keywords

ADJUVANT; AMPHOPHILE; B LYMPHOCYTE ANTIGEN; CANCER VACCINE; CHITOSAN; COPOLYMER; CPG OLIGODEOXYNUCLEOTIDE; EPITOPE; FREUND ADJUVANT; HEMAGGLUTININ; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HERPES SIMPLEX VACCINE; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; MESSENGER RNA; N (2 HYDROXYPROPYL) METHACRYLAMIDE COPOLYMER; NANOCARRIER; NANOPARTICLE; POLYCYTIDYLIC ACID; POLYETHYLENEIMINE; POLYGLUTAMIC ACID; POLYLACTIDE; POLYLYSINE; POLYMETHACRYLIC ACID; PROTEIN E7; STAT3 PROTEIN; STEARIC ACID; SUBUNIT VACCINE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SEQUENCE; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ANTIGENICITY; CELLULAR IMMUNITY; CPG ISLAND; CROSS PRESENTATION; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DNA IMMUNIZATION; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ENDOSOME; HERPES SIMPLEX; HUMAN; IMMUNOGENICITY; MICELLE; NONHUMAN; PH RESPONSIVE MICELLE; REVIEW; TH1 CELL;

EID: 85016879990     PISSN: None     EISSN: 2076393X     Source Type: Journal    
DOI: 10.3390/vaccines3040803     Document Type: Review

References (41)

1. De Gregorio, E.; Rappuoli, R. From empiricism to rational design: A personal perspective of the evolution of vaccine development. Nat. Rev. Immunol. 2014, 14, 505–514.
2. Alving, C.R.; Peachman, K.K.; Rao, M.; Reed, S.G. Adjuvants for human vaccines. Curr. Opin. Immunol. 2012, 24, 310–315.
3. Fox, C.B.; Haensler, J. An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants. Expert Rev. Vaccines 2013, 12, 747–758.
4. Gregoriadis, G.; McCormack, B.; Obrenovic, M.; Saffie, R.; Zadi, B.; Perrie, Y. Liposomes as immunological adjuvants and vaccine carriers. Methods 1999, 19, 156–162.
5. Rice-Ficht, A.C.; Arenas-Gamboa, A.M.; Kahl-McDonagh, M.M.; Ficht, T.A. Polymeric particles in vaccine delivery. Curr. Opin. Microbiol. 2010, 13, 106–112.
6. Croy, S.R.; Kwon, G.S. Polymeric micelles for drug delivery. Curr. Pharm. Des. 2006, 12, 4669–4684.
7. Luo, Z.; Shi, S.; Jin, L.; Xu, L.; Yu, J.; Chen H.; Li, X. Cationic micelle based vaccine induced potent humoral immuneresponse through enhancing antigen uptake and formation of germinal center. Colloids Surf. B 2015, 135, 556–564.
8. Moyano, D.F.; Goldsmith, M.; Solfiell, D.J.; Landesman-Milo, D.; Miranda, O.R.; Peer, D.; Rotello, V.M. Nanoparticle hydrophobicity dictates immune response. J. Am. Chem. Soc. 2012, 134, 3965–3967.
9. Hara, E.; Ueda, M.; Makino, A.; Hara, I.; Ozeki, E.; Kimura, S. Factors influencing in vivo disposition of polymeric micelles on multiple administrations. ACS Med. Chem. Lett. 2014, 5, 873–877.
10. Kim, C.J.; Hara, E.; Shimizu, A.; Sugai, M.; Kimura, S. Activation of B1a cells in peritoneal cavity by T cell-independent antigen expressed on polymeric micelle. J. Pharm. Sci.2015, 104, 1839–1847.
11. Hara, E.; Ueda, M.; Kim, C.J.; Makino, A.; Hara, I.; Ozeki, E.; Kimura, S. Suppressive immune response of poly(sarcosine) chains in peptide-nanosheets in contrast to polymeric micelles. J. Pept. Sci. 2014, 20, 570–577.
12. Aguado, M.T.; Lambert, P.H. Controlled-release vaccines-biodegradable polylactide/polyglycolide (PL/PG) microspheres as antigen vehicles. Immunobiology 1992, 184, 113–125.
13. Pavot, V.; Rochereau, N.; Primard, C.; Genin, C.; Perouzel, E.; Lioux, T.; Paul, S.; Verrier, B. Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties. J. Control. Release 2013, 167, 60–67.
14. Jiménez-Sánchez, G.; Pavot, V.; Chane-Haong, C.; Handké, N.; Terrat, C.; Gigmes, D.; Trimaille, T.; Verrier, B. Preparation and In Vitro Evaluation of Imiquimod loaded polylactide-based micelles as potential vaccine adjuvants. Pharm. Res. 2015, 32, 311–320.
15. Jain, A.K.; Goyal, A.K.; Gupta, P.N.; Khatri, K.; Mishra, N.; Mehta, A.; Mangal, S.; Vyas, S.P. Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B. J. Control. Release 2009, 136, 161–169.
16. Jain, A.K.; Goyal, A.K.; Mishra, N.; Vaidya, B.; Mangal, S.; Vyas, S.P. PEG-PLA-PEG block copolymeric nanoparticles for oral immunization against hepatitis B. Int. J. Pharm.2010, 387, 253–262.
17. Luo, Z.; Li, P.; Deng, J.; Gao, N.; Zhang, Y.; Pan, H.; Liu, L.; Wang, C.; Cai, L.; Ma, Y. Cationic polypeptide micelle-based antigen delivery system: A simple and robust adjuvant to improve vaccine efficacy. J. Control. Release 2013, 170, 259–267.
18. Luo, Z.; Wang, C.; Yi, H.; Li, P.; Pan, H.; Liu, L.; Cai, L.; Ma, Y. Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo. Biomaterials 2015, 38, 50–60.
19. Noh, Y.W.; Hong, J.H.; Shim, S.M.; Park, H.S.; Bae, H.H.; Ryu, E.K.; Hwang, J.H.; Lee, C.H.; Cho, S.H.; Sung, M.H. et al. Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity. Angew. Chem. Int. Ed. 2013, 52, 7684–7689.
20. Hyungjin, K.; Tomofumi, U.; Takami, A.; Masanori, B.; Mitsuru, A. Amphiphilic Poly(amino acid) nanoparticles induce size-dependent dendritic cell maturation. Adv. Funct. Mater. 2010, 20, 3925–3931.
21. Matsuo, K.; Koizumi, H.; Akashi, M.; Nakagawa, S.; Fujita, T.; Yamamoto, A.; Okada, N. Intranasal immunization with poly(g-glutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity. J. Control. Release 2011, 152, 310–316.
22. Okamoto, S.; Yoshii, H.; Matsuura, M.; Kojima, A.; Ishikawa, T.; Akagi, T.; Akashi, M.; Takahashi, M.; Yamanishi, K.; Mori, Y. Poly-γ-glutamic acid nanoparticles and aluminium adjuvant used as an adjuvant in a single dose of Japanese Encephalitis virus-like particles provide effective protection from Japanese Encephalitis virus. Clin. Vaccine Immunol. 2012, 19, 17–22.
23. Hao, J.; Kwissa, M.; Pulendran, B.; Murthy, N. Peptide crosslinked micelles: A new strategy for the design and synthesis of peptide vaccines. Int. J. Nanomed. 2006, 1, 97–103.
24. Keller, S.; Wilson, J.T.; Patilea, G.I.; Kern, H.B.; Convertine, A.J.; Stayton, P.S. Neutral polymer micelle carriers with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8+ T cell responses. J. Control. Release 2014, 191, 24–33.
25. Wilson, J.T.; Keller, S.; Manganiello, M.J.; Cheng, C.; Lee, C.C.; Opara, C.; Convertine, A.; Stayton, P.S. pH-Responsive nanoparticle vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides. ACS Nano 2013, 7, 3912–3925.
26. Boudier, A.; Aubert-Pouessel, A.; Louis-Plence, P.; Gerardin, C.; Jorgensen, C.; Devoisselle, J.M.; Begu, S. The control of dendritic cell maturation by pH-sensitive polyion complex micelles. Biomaterials 2009, 30, 233–241.
27. Boudier, A.; Aubert-Pouessel, A.; Mebarek, N.; Chavanieu, A.; Quentin, J.; Martire, D.; Boukhaddaoui, H.; Gerardin, C.; Jorgensen, C.; Devoisselle, J.M. et al. Development of tripartite polyion micelles for efficient peptide delivery into dendritic cells without altering their plasticity. J. Control. Release 2011, 154, 156–163.
28. Eby, J.K.; Dane, K.Y.; O’Neil, C.P.; Hirosue, S.; Swartz, M.A.; Hubbell, J.A. Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization. Acta Biomater. 2012, 8, 3210–3217.
29. Zeng, Q.; Jiang, H.; Wang, T.; Zhang, Z.; Gong, T.; Sun, X. Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. J. Control. Release 2015, 200, 1–12.
30. Layek, B.; Lipp, L.; Singh, J. APC targeted micelle for enhanced intradermal delivery of hepatitis B DNA vaccine. J. Control. Release 2015, 207, 143–153.
31. Yang, Y.; Kuang, Y.; Liu, Y.; Li, W.; Jiang, Z.; Xiao, L.; Li, M. Immunogenicity of multiple-epitope antigen gene of HCV carried by novel biodegradable polymers. Comp. Immunol. Microbiol. Infect. Dis. 2011, 34, 65–72.
32. Furugaki, K.; Cui, L.; Kunisawa, Y.; Osada, K.; Shinkai, K.; Tanaka, M.; Kataoka, K.; Nakano, K. Intraperitoneal administration of a tumor-associated antigen SART3, CD40L, and GM-CSF gene-loaded polyplex micelle elicits a vaccine effect in mouse tumor models. PLoS ONE 2014, 9, e101854.
33. Cui, L.; Osada, K.; Imaizumi, A.; Kataoka, K.; Nakano, K. Feasibility of a subcutaneously administered block/homo-mixed polyplex micelle as a carrier for DNA vaccination in a mouse tumor model. J. Control. Release 2015, 206, 220–231.
34. Miyata, K.; Oba, M.; Nakanishi, M.; Fukushima, S.; Yamasaki, Y.; Koyama, H.; Nishiyama, N.; Kataoka, K. Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J. Am. Chem. Soc. 2008, 130, 16287–16294.
35. Zhao, M.; Li, M.; Zhang, Z.; Gong, T.; Sun, X. Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA. Drug Deliv. 2015, doi:10.3109/10717544.2015.1038856.
36. Black, M.; Trent, A.; Kostenko, Y.; Lee, J.S.; Olive, C.; Tirrell, M. Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo. Adv. Mater. 2012, 24, 3845–3849.
37. Trent, A.; Ulery, B.D.; Black, M.J.; Barrett, J.C.; Liang, S.; Kostenko, Y.; David, N.A.; Tirrell, M.V. Peptide amphiphile micelles self-adjuvant group A streptococcal vaccination. AAPS J. 2015, 17, 380–388.
38. Accardo, A.; Vitiello, M.; Tesauro, D.; Galdiero, M.; Finamore, E.; Martora, F.; Mansi, R.; Ringhieri, P.; Morelli, G. Self-assembled or mixed peptide amphiphile micelles from Herpes simplex virus glycoproteins as potential immunomodulatory treatment. Int. J. Nanomed.2014, 9, 2137–2148.
39. Liu, H.; Moynihan, K.D.; Zheng, Y.; Szeto, G.L.; Li, A.V.; Huang, B.; van Egeren, D.S.; Park, C.; Irvine, D.J. Structure-based programming of lymph-node targeting in molecular vaccines. Nature 2014, 507, 519–522.
40. Skwarczynski, M.; Zaman, M.; Urbani, C.N.; Lin, I.C.; Jia, Z.; Batzloff, M.R.; Good, M.F.; Monteiro, M.J.; Toth, I. Polyacrylate dendrimer nanoparticles: A self-adjuvanting vaccine delivery system. Angew. Chem. Int. Ed. 2010, 49, 5742–5745.
41. Zope, H.; Quer, C.B.; Bomans, P.H.; Sommerdijk, N.A.; Kros, A.; Jiskoot, W. Peptide amphiphile nanoparticles enhance the immune response against a CpG-adjuvanted influenza antigen. Adv. Healthc. Mater. 2014, 3, 343–348.